Diabetes, oxidative stress and physical exercise

Journal of Sports Science and Medicine

Volumn 1, Issue 1, 2002, Pages 1-14

  Atalay, Mustafa ^a   Laaksonen, David E ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Antioxidants; Diabetes; Physical activity; Reactive oxygen species

Indexed keywords

EID: 2942662761     PISSN: 13032968     EISSN: 13032968     Source Type: Journal    
DOI: None     Document Type: Review

References (145)

1. American Diabetes Association: clinical practice recommendations (1998) Diabetes Care 21, S1-95.
2. Adachi, T., Yamada, H., Yamada, Y., Morihara, N., Yamazaki, N., Murakami, T., Futenma, A., Kato, K., and Hirano, K. (1996) Substitution of glycine for arginino-213 in extracellular-superoxide dismutase impairs affinity for heparin and endothelial cell surface. Biochemical Journal 313:Part 1, 235-239.
3. Ahotupa, M., Marniemi, J., Lehtimaki, T., Talvinen, K., Raitakari, O.T., Vasankari, T., Viikari, J., Luoma, J., and Yla-Herttuala, S. (1998) Baseline diene conjugation in LDL lipids as a direct measure of in vivo LDL oxidation. Clinical Biochemistry 31, 257-261.
4. Akkus, I., Kalak, S., Vural, H., Caglayan, O., Menekse, E., Can, G., and Durmus, B. (1996) Leukocyte lipid peroxidation, superoxide dismutase, glutathione peroxidase and serum and leukocyte vitamin C levels of patients with type II diabetes mellitus. Clinica Chimica Acta 244, 221-227.
5. Altomare, E., Grattagliano, I., Vendemaile, G., Micelli-Ferrari, T., Signorile, A., and Cardia, L. (1997) Oxidative protein damage in human diabetic eye: evidence of a retinal participation. European Journal of Clinical Investigation 27, 141-147.
6. Altomare, E., Vendemiale, G., Chicco, D., Procacci, V., and Cirelli, F. (1992) Increased lipid peroxidation in type 2 poorly controlled diabetic patients. Diabetes & Metabolism 18, 264-271.
7. Arai, K., Iizuka, S., Tada, Y., Oikawa, K., and Taniguchi, N. (1987) Increase in the glucosylated form of erythrocyte Cu-Zn-superoxide dismutase in diabetes and close association of the nonenzymatic glucosylation with the enzyme activity. Biochimica et Biophysica Acta 924, 292-296.
8. Armstrong, A.M., Chestnutt, J.E., Gormley, M.J., and Young, I.S. (1996) The effect of dietary treatment on lipid peroxidation and antioxidant status in newly diagnosed noninsulin dependent diabetes. Free Radical Biology and Medicine 21, 719-726.
9. Asayama, K., Uchida, N., Nakane, T., Hayashibe, H., Dobashi, K., Amemiya, S., Kato, K., and Nakazawa, S. (1993) Antioxidants in the serum of children with insulin-dependent diabetes mellitus. Free Radical Biology and Medicine 15, 597-602.
10. Atalay, M., Laaksonen, D.E., Khanna, S., Kaliste-Korhonen, E., Hanninen, O., and Sen, C.K. (2000) Vitamin E regulates changes in tissue antioxidants induced by fish oil and acute exercise. Medicine and Science in Sports and Exercise 32, 601-607.
11. Atalay, M., Laaksonen, D.E., Niskanen, L., Uusitupa, M., and Hanninen, O., Sen, C.K. (1997) Altered antioxidant enzyme defences in insulin-dependent diabetic men with increased resting and exercise-induced oxidative stress. Acta Physiologica Scandinavica 161, 195-201.
12. Atalay, M., Marnila, P., Lilius, E.M., Hanninen, O., and Sen, C.K. (1996a) Glutathione-dependent modulation of exhausting exercise-induced changes in neutrophil function of rats. European Journal of Applied Physiology and Occupational Physiology 74, 342-347.
13. Atalay, M., Seene, T., Hanninen, O., and Sen, C.K. (1996b) Skeletal muscle and heart antioxidant defences in response to sprint training. Acta Physiologica Scandinavica 158, 129-134.
14. Atalay, M., and Sen, C.K. (1999) Physical exercise and antioxidant defenses in the heart. Annals New York Academy of Sciences 874, 169-177.
15. Baynes, J.W. (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40, 405-412.
16. Bellomo, G., Maggi, E., Poli, M., Agosta, F.G., Bollati, P., and Finardi, G. (1995) Autoantibodies against oxidatively modified low-density lipoproteins in NIDDM. Diabetes 44, 60-66.
17. Blakytny, R., and Harding, J.J. (1992) Glycation (non-enzymic glycosylation) inactivates glutathione reductase. Biochemical Journal 288, 303-307.
18. Bowie, A., Owens, D., Collins, P., Johnson, A., and Tomkin, G.H. (1993) Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? Atherosclerosis 102, 63-67.
19. Bravi, M.C., Pietrangeli, P., Laurenti, O., Basili, S., Cassone Faldetta, M., Ferri, C., and De Mattia, G. (1997) Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients. Metabolism 46, 1194-1198.
20. Cakatay, U., Telci, A., Salman, S., Satman, L., and Sivas, A. (2000) Oxidative protein damage in type I diabetic patients with and without complications. Endocrine Research 26, 365-379.
21. Cameron, N.B., and Cotter, M.A. (1993) Potential therapeutic approaches to the treatment or prevention of diabetic neuropathy: evidence from experimental studies. Diabetic Medicine 10, 593-605.
22. Cameron, N.B., Cotter, M.A, and Hohman, T.C. (1996) Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. Diabetologia 39, 172-182.
23. Cederberg, J., Basu, S., and Eriksson, U.J. (2001) Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy. Diabetologia 44, 766-774.
24. Ceriello, A., Bortolotti, N., Falleti, E., Taboga, C., Tonutti, L., Crescentini, A., Motz, E., Lizzio, S., Russo, A., and Bartoli, E. (1997) Total radical-trapping antioxidant parameter in NIDDM patients. Diabetes Care 20, 194-197.
25. Ceriello, A., Giugliano, D., Quatraro, A., Dello-Russo, P., and Lefebvre, P.J. (1991) Metabolic control may influence the increased superoxide generation in diabetic serum. Diabetic Medicine 8, 540-542.
26. Ceriello, A., Mercuri, F., Quagliaro, L., Assaloni, R., Motz, E., Tonutti, L., and Taboga, C. (2001) Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress. Diabetologia 44, 834-838.
27. Chevion, M., Berenshtein, E., and Stadtman, E.R. (2000) Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radical Research 33 Suppl, S99-108.
28. Collier, A., Rumley, A., Rumley, AG., Paterson, J.R., Leach, J.P., Lowe, G.D., and Small, M. (1992) Free radical activity and hemostatic factors in NIDDM patients with and without microalbuminuria. Diabetes 41, 909-913.
29. Dandona, P., Thusu, K., Cook, S., Snyder, B., Makowski, J., Armstrong, D., and Nicotera, T. (1996) Oxidative damage to DNA in diabetes mellitus. Lancet 347, 444-445.
30. Davies, K.J., Quintanilha, A.T., Brooks, G.A., and Packer, L. (1982) Free radicals and tissue damage produced by exercise. Biochemical and Biophysical Research Communications107, 1198-1205.
31. De Mattia, G., Laurenti, O., Bravi, C., Ghiselli, A., Iuliano, L., and Balsano, F. (1994) Effect of aldose reductase inhibition on glutathione redox status in erythrocytes of diabetic patients. Metabolism 43, 965-968.
32. Desfaits, A.C., Serri, O., and Renier, G. (1998) Normalization of plasma lipid peroxides, monocyte adhesion, and tumor necrosis factor-alpha production in NIDDM patients after gliclazide treatment. Diabetes Care 21, 487-493.
33. Di Simplicio, P., de Giorgio, L.A., Cardaioli, E., Lecis, R., Miceli, M., Rossi, R., Anichini, R., Mian, M., Seghieri, G., and Franconi, F. (1995) Glutathione, glutathione utilizing enzymes and thioltransferase in platelets of insulin-dependent diabetic patients: relation with platelet aggregation and with microangiopatic complications. European Journal of Clinical Investigation 25, 665-669.
34. Dillard, C.J., Litov, R.E., Savin, W.M., Dumelin, E.E., and Tappel, A.L. (1978) Effects of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation. Journal of Applied Physiology 45, 927-932.
35. Dominguez, C., Ruiz, E., Gussinye, M., and Carrascosa, A. (1998) Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diabetes Care 21, 1736-1742.
36. Draper, H.H., Squires, E.J., Mahmoodi, H., Wu, J., Agarwal, S., and Hadley, M. (1993) A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radical Biology and Medicine 15, 353-363.
37. Dyer, D.G., Dunn, J.A., Thorpe, S.R., Bailie, K.E., Lyons, T.J., McCance, D.R., and Baynes, J.W. (1993) Accumulation of Maillard reaction products in skin collagen in diabetes and aging. The Journal of Clinical Investigation 91, 2463-2469.
38. Elgawish, A., Glomb, M., Friedlander, M., and Monnier, V.M. (1996) Involvement of hydrogen peroxide in collagen cross-linking by high glucose in vitro and in vivo. J. Biol. Chem 271, 12964-12971.
39. Evans, R.W., and Orchard, T.J. (1994) Oxidized lipids in insulin-dependent diabetes mellitus: a sex-diabetes interaction? Metabolism 43, 1196-1200.
40. Faure, P., Benhamou, P.Y., Perard, A., Halimi, S., and Roussel, AM. (1995) Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation. Eur. J. Clin. Nutr. 49, 282-288.
41. Faure, P., Corticelli, P., Richard, M.J., Arnaud, J., Coudray, C., Halimi, S., Favier, A., and Roussel, A.M. (1993) Lipid peroxidation and trace element status in diabetic ketotic patients: influence of insulin therapy. Clinical Chemistry 39, 789-793.
42. Festa, A., Kopp, H.P., Schernthaner, G., and Menzel, E.J. (1998) Autoantibodies to oxidised low density lipoproteins in IDDM are inversely related to metabolic control and microvascular complications. Diabetologia. 41, 350-356.
43. Freitas, J.P., Filipe, P.M., and Rodrigo, F.G. (1997) Lipid peroxidation in type 2 normolipidemic diabetic patients. Diabetes Research and Clinical Practice 36, 71-75.
44. Fujiwara, Y., Kondo, T., Murakami, K., and Kawakami, Y. (1989) Decrease of the inhibition of lipid peroxidation by glutathione-dependent system in erythrocytes of non-insulin dependent diabetics. Klin. Wochenschr. 67, 336-341.
45. Gallou, G., Ruelland, A., Legras, B., Maugendre, D., Allannic, H., and Cloarec, L. (1993) Plasma malondialdehyde in type 1 and type 2 diabetic patients. Clinica Chimica Acta 214, 227-234.
46. Ghiselli, A., Laurenti, O., De Mattia, G., Maiani, G., and Ferro Luzzi, A. (1992) Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients. Free Radical Biology and Medicine 13, 621-626.
47. Giugliano, D., Ceriello, A., and Paolisso, G. (1996) Oxidative stress and diabetic vascular complications. Diabetes Care 19, 257-267.
48. Godin, D.V., Wohaieb, S.A., Garnett, M.E., and Goumeniouk, A.D. (1988) Antioxidant enzyme alterations in experimental and clinical diabetes. Mol. Cell. Biochem. 84, 223-231.
49. Goldfarb, AH., McIntosh, M.K., and Boyer, B.T. (1996) Vitamin E attenuates myocardial oxidative stress induced by DHEA in rested and exercised rats. Journal of Applied Physiology 80, 486-490.
50. Griesmacher, A., Kindhauser, M., Andert, S.E., Schreiner, W., Toma, C., Knoebl, P., Pietschmann, P., Prager, R, Schnack, C., and Schernthaner, G. (1995) Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus. Am. J. Med. 98, 469-475.
51. Griffin, M.E., McInerney, D., Fraser, A., Johnson, AH., Collins, P.B., Owens, D., and Tomkin, G.H. (1997) Autoantibodies to oxidized low density lipoprotein: the relationship to low density lipoprotein fatty acid composition in diabetes. Diabetic Medicine 14, 741-747.
52. Grunewald, R.W., Weber, II, Kinne Saffran, E., and Kinne, RK. (1993) Control of sorbitol metabolism in renal inner medulla of diabetic rats: regulation by substrate, cosubstrate and products of the aldose reductase reaction. Biochimica et Biophysica Acta 1225, 39-47.
53. Gugliucci, A., Menini, T., and Stahl, A.J. (1994) Susceptibility to copper-enhanced autoxidation of VLDL+LDL fractions from diabetic patients. Biochem. Mol. Biol. Int. 32, 139-147.
54. Gul, M., Laaksonen, D.E., Atalay, M., Vider, L., and Hanninen, O. (2002) Endurance training decreases oxidative stress in streptozotocin induced diabetic rat. Scandinavian Journal of Sports Medicine and Sports, in press.
55. Haffner, S.M., Agil, A., Mykkanen, L., Stem, M.P., and Jialal, I. (1995) Plasma oxidizability in subjects with normal glucose tolerance, impaired glucose tolerance, and NIDDM. Diabetes Care 18, 646-653.
56. Hermes-Lima, M., Willmore, W.G., and Storey, K.B. (1995) Quantification of lipid peroxidation in tissue extracts based on Fe(III)xylenol orange complex formation. Free Radical Biology and Medicine 19, 271-280.
57. Hsu, R.M., Devaraj, S., and Jialal, I. (2002) Autoantibodies to oxidized low-density lipoprotein in patients with Type 2 diabetes mellitus. Clinica Chimica Acta 317, 145-150.
58. Hunt, J.V., Smith, C.C., and Wolff, S.P. (1990) Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39, 1420-1424.
59. Jain, S.K., and McVie, R. (1994) Effect of glycemic control, race (white versus black), and duration of diabetes on reduced glutathione content in erythrocytes of diabetic patients. Metabolism 43, 306-309.
60. Jang, Y.Y., Song, J.H., Shin, Y.K., Han, E.S., and Lee, C.S. (2000) Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats. Pharmacological Research 42, 361-371.
61. Jenkins, A.J., Klein, R.L., Chassereau, C.N., Hermayer, K.L., and Lopes Virella, M.F. (1996) LDL from patients with well-controlled IDDM is not more susceptible to in vitro oxidation. Diabetes 45, 762-767.
62. Jennings, P.E., McLaren, M., Scott, N.A., Saniabadi, A.R., and Belch, J.J. (1991) The relationship of oxidative stress to thrombotic tendency in type 1 diabetic patients with retinopathy. Diabetic Medicine 8, 860-865.
63. Ji, L.L. (1999) Antioxidants and oxidative stress in exercise. Proceedings of the Society for Experimental Biology and Medicine 222, 283-292.
64. Jones, A.F., Winkles, J.W., Thornalley, P.J., Lunec, J., Jennings, P.E., and Barnett, A.H. (1987) Inhibitory effect of superoxide dismutase on fructosamine assay. Clinical Chemistry 33, 147-149.
65. Kaneto, H., Fujii, J., Myint, T., Miyazawa, N., Islam, K.N., Kawasaki, Y., Suzuki, K., Nakamura, M., Tatsumi, H., Yamasaki, Y., and Taniguchi, N. (1996) Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction. Biochemical Journal 320, 855-863.
66. Kashiwagi, A., Asahina, T., Ikebuchi, M., Tanaka, Y., Takagi, Y., Nishio, Y., Kikkawa, R., and Shigeta, Y. (1994) Abnormal glutathione metabolism and increased cytotoxicity caused by H2O2 in human umbilical vein endothelial cells cultured in high glucose medium. Diabetologia 37, 264-269.
67. Kashiwagi, A., Asahina, T., Nishio, Y., Ikebuchi, M., Tanaka, Y., Kikkawa, R., and Shigeta, Y. (1996) Glycation, oxidative stress, and scavenger activity: glucose metabolism and radical scavenger dysfunction in endothelial cells. Diabetes 45, S84-S86.
68. Kawamura, M., Heinecke, J.W., and Chait, A. (1994) Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway. The Journal of Clinical Investigation 94, 771-778.
69. Kawamura, N., Ookawara, T., Suzuki, K., Konishi, K., Mino, M., and Taniguchi, N. (1992) Increased glycated Cu,Zn-superoxide dismutase levels in erythrocytes of patients with insulin-dependent diabetis mellitus. The Journal of Clinical Endocrinology and Metabolism 74, 1352-1354.
70. Khanna, S., Atalay, M., Laaksonen, D.E., Gul, M., Roy, S., and Sen, C.K. (1999) Alpha-lipoic acid supplementation: tissue glutathione homeostasis at rest and after exercise. Journal of Applied Physiology 86, 1191-1196.
71. Kihlstrom, M., Ojala, J., and Salminen, A. (1989) Decreased level of cardiac antioxidants in endurance-trained rats. Acta Physiologica Scandinavica 135, 549-554.
72. Kim, J.D., Yu, B.P., McCarter, R.J.M., Lee, S.Y., and Herlihy, J.T. (1996) Exercise and diet modulate cardiac lipid peroxidation and antioxidant defenses. Free Radical Biology and Medicine 20, 83-88.
73. Korpinen, E., Groop, P.H., Akerblom, H.K., and Vaarala, O. (1997) Immune response to glycated and oxidized LDL in IDDM patients with and without renal disease. Diabetes Care 20, 1168-1171.
74. Laaksonen, D.E., Atalay, M., Niskanen, L., Uusitupa, M., and Hanninen, O., Sen, C.K. (1996) Increased resting and exercise-induced oxidative stress in young IDDM men. Diabetes Care 19, 569-574.
75. Laaksonen, D.E., Atalay, M., Niskanen, L.K., Mustonen, J., Sen, C.K., Lakka, T.A., and Uusitupa, M.I. (2000) Aerobic exercise and the lipid profile in type 1 diabetic men: a randomized controlled trial. Medicine and Science in Sports and Exercise 32, 1541-1548.
76. Laaksonen, D.E., and Sen, C.K.(2000) Exercise and Oxidative Stress in Diabetes Mellitus. In: Handbook of Oxidants and Antioxidants in Exercise. Ed: Sen CK, Packer L and Hanninen O. Amsterdam: Elsevier, 1105-1136.
77. Lakka, T.A., Venalainen, J.M., Rauramaa, R., Salonen, R., Tuomilehto, J., and Salonen, J.T. (1994) Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction. The New England Journal of Medicine 330, 1549-1554.
78. Leonard, M.B., Lawton, K., Watson, I.D., Patrick, A., Walker, A., and MacFarlane, I. (1995) Cigarette smoking and free radical activity in young adults with insulin-dependent diabetes. Diabetic Medicine 12, 46-50.
79. Lyons, T.J. (1993) Glycation and oxidation: a role in the pathogenesis of atherosclerosis. The American Journal of Cardiology 71, 26B-31B.
80. MacRury, S.M., Gordon, D., Wilson, R., Bradley, H., Gemmell, C.G., Paterson, J.R., Rumley, A.G., and MacCuish, A.C. (1993) A comparison of different methods of assessing free radical activity in type 2 diabetes and peripheral vascular disease. Diabetic Medicine 10, 331-335.
81. Maejima, K., Nakano, S., Himeno, M., Tsuda, S., Makiishi, H., Ito, T., Nakagawa, A., Kigoshi, T., Ishibashi, T., Nishio, M., and Uchida, K. (2001) Increased basal levels of plasma nitric oxide in Type 2 diabetic subjects. Relationship to microvascular complications. Journal of Diabetes and its Complications 15, 135-143.
82. Mannervik, B., and Danielson, U.K. (1988) Glutathione transferases - structure and catalytic activity. CRC. Critical Reviews in Biochemistry 23, 283-337.
83. Marra, G., Cotroneo, P., Pitocco, D., Manto, A., Di Leo, M.A., Ruotolo, V., Caputo, S., Giardina, B., Ghirlanda, G., and Santini, S.A. (2002) Early Increase of Oxidative Stress and Reduced Antioxidant Defenses in Patients With Uncomplicated Type 1 Diabetes: A case for gender difference. Diabetes Care 25, 370-375.
84. McDermott, B.M., Flatt, P.R., and Strain, J.J. (1994) Effects of copper deficiency and experimental diabetes on tissue antioxidant enzyme levels in rats. Annals of Nutrition & Metabolism 38, 263-269.
85. Meister, A. (1995) Glutathione metabolism. Methods in Enzymology 251, 3-7.
86. Mironova, M., Virella, G., Virella Lowell, I., and Lopes Virella, M.F. (1997) Anti-modified LDL antibodies and LDL-containing immune complexes in IDDM patients and healthy controls. Clinical Immunology and Immunopathology 85, 73-82.
87. Mol, M.J., de Rijke, Y.B., Demacker, P.N., and Stalenhoef, A.F. (1997) Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. Atherosclerosis 129, 169-176.
88. Muruganandam, A., Brouillard, C., Thibert, R.J., Cheung, R.M., Draisey, T.F., and Mutus, B. (1992) Glutathione metabolic enzyme activities in diabetic platelets as a function of glycemic control. Thrombosis Research 67, 385-397.
89. Nacitarhan, S., Ozben, T., and Tuncer, N. (1995) Serum and urine malondialdehyde levels in NIDDM patients with and without hyperlipidemia. Free Radical Biology and Medicine 19, 893-896.
90. Nath, N., Chari, S.N., and Rathi, A.B. (1984) Superoxide dismutase in diabetic polymorphonuclear leukocytes. Diabetes 33, 586-589.
91. Neri, S., Bruno, C.M., Raciti, C., Dangelo, G., Damico, R., and Cristaldi, R. (1994) Alteration of oxide reductive and haemostatic factors in type 2 diabetics. Journal of Internal Medicine 236, 495-500.
92. Niskanen, L.K., Salonen, J.T., Nyyssonen, K., and Uusitupa, M.I. (1995) Plasma lipid peroxidation and hyperglycaemia: a connection through hyperinsulinaemia? Diabetic Medicine 12, 802-808.
93. Noberasco, G., Odetti, P., Boeri, D., Maiello, M., and Adezati, L. (1991) Malondialdehyde (MDA) level in diabetic subjects. Relationship with blood glucose and glycosylated hemoglobin. Biomedecine & Pharmacotherapy 45, 193-196.
94. Nourooz Zadeh, J., Rahimi, A., Tajaddini Sarmadi, J., Tritschler, H., Rosen, P., Halliwell, B., and Betteridge, D.J. (1997) Relationships between plasma measures of oxidative stress and metabolic control in NIDDM. Diabetologia 40, 647-653.
95. Nourooz-Zadeh, J., Tajaddini-Sarmadi, J., McCarthy, S., Betteridge, D.J., and Wolff, S.P. (1995) Elevated levels of authentic plasma hydroperoxides in NIDDM. Diabetes 44, 1054-1058.
96. O-Brien, S., Mori, T.A., Puddey, I.E., and Stanton, K.G. (1995) Absence of increased susceptibility of LDL to oxidation in type 1 diabetics. Diabetes Research and Clinical Practice 30, 195-203.
97. Obrosova, I.G., Van Huysen, C., Fathallah, L., Cao, X.C., Greene, D.A., and Stevens, M.J. (2002) An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense. The FASEB Journal 16, 123-125.
98. Osterode, W., Holler, C., and Ulberth, F. (1996) Nutritional antioxidants, red cell membrane fluidity and blood viscosity in type 1 (insulin dependent) diabetes mellitus. Diabetic Medicine 13, 1044-1050.
99. Ou, P., and Wolff, S.P. (1994) Erythrocyte catalase inactivation (H2O2 production) by ascorbic acid and glucose in the presence of aminotriazole: role of transition metals and relevance to diabetes. Biochemical Journal 303, 935-939.
100. Ozben, T., Nacitarhan, S., and Tuncer, N. (1995) Plasma and urine malondialdehyde levels in non-insulin-dependent diabetic patients with and without microalbuminuria. Int J Clin Lab Res 25, 162-164.
101. Paffenbarger, R.S., Jr., Kampert, J.B., Lee, I.M., Hyde, R.T., Leung, R.W., and Wing, A.L. (1994) Changes in physical activity and other lifeway patterns influencing longevity. Medicine and Science in Sports and Exercise 26, 857-865.
102. Peuchant, E., Delmas Beauvieux, M.C., Couchouron, A., Dubourg, L., Thomas, M.J., Perromat, A., Clerc, M., and Gin, H. (1997) Short-term insulin therapy and normoglycemia. Effects on erythrocyte lipid peroxidation in NIDDM patients. Diabetes Care 20, 202-207.
103. Powers, S.K., Coombes, J., and Demirel, H. (1997) Exercise training-induced changes in respiratory muscles. Sports Medicine 24, 120-131.
104. Powers, S.K., Ji, L.L., and Leeuwenburgh, C. (1999) Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Medicine and Science in Sports and Exercise 31, 987-997.
105. Rabini, R.A., Fumelli, P., Galassi, R., Dousset, N., Taus, M., Ferretti, G., Mazzanti, L., Curatola, G., Solera, M.L., and Valdiguie, P. (1994) Increased susceptibility to lipid oxidation of low-density lipoproteins and erythrocyte membranes from diabetic patients. Metabolism 43, 1470-1474.
106. Sakurai, T., and Tsuchiya, S. (1988) Superoxide production from nonenzymatically glycated protein. FEBS Letters 236, 406-410.
107. Salonen, J.T., Yla Herttuala, S., Yamamoto, R., Butler, S., Korpela, H., Salonen, R., Nyyssonen, K., Palinski, W., and Witztum, J.L. (1992) Autoantibody against oxidised LDL and progression of carotid atherosclerosis [see comments].Lancet 339, 883-887.
108. Santini, S.A., Marra, G., Giardina, B., Cotroneo, P., Mordente, A., Martorana, G.E., Manto, A., and Ghirlanda, G. (1997) Defective plasma antioxidant defenses and enhanced susceptibility to lipid peroxidation in uncomplicated IDDM. Diabetes 46, 1853-1858.
109. Sato, Y., Hotta, N., Sakamoto, N., Matsuoka, S., Ohishi, N., and Yagi, K. (1979) Lipid peroxide level in the plasma of diabetic patients. Biochemical Medicine and Metabolic Biology 21(1),104-107.
110. Schleicher, E.D., Wagner, E., and Nerlich, A.G. (1997) Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. The Journal of Clinical Investigation 99, 457-468.
111. Selamoglu, S., Turgay, F., Kayatekin, B.M., Gonenc, S., and Islegen, C. (2000) Aerobic and anaerobic training effects on the antioxidant enzymes of the blood. Acta Physiologica Hungarica 87, 267-273.
112. Sell, D.R., Lapolla, A., Odetti, P., Fogarty, J., and Monnier, V.M. (1992) Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM. Diabetes 41, 1286-1292.
113. Sen, C.K. (1995) Oxidants and antioxidants in exercise. Journal of Applied Physiology 79, 675-686.
114. Sen, C.K. (1999) Glutathione homeostasis in response to exercise training and nutritional supplements. Mol Cell Biochem 196, 31-42.
115. Sen, C.K., Atalay, M., and Hanninen, O. (1994a) Exercise-induced oxidative stress: glutathione supplementation and deficiency. Journal of Applied Physiology 77, 2177-2187.
116. Sen, C.K., and Hanninen, O. (1994) Physiological antioxidants. In: Exercise and oxygen toxicity. Ed: Sen CK, Packer L and Hanninen O. Amsterdam: Elsevier, 89-126.
117. Sen, C.K., and Packer, L. (2000) Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 72, 653S-669S.
118. Sen, C.K., Packer, L., and Hanninen, O. (1994b) Exercise and Oxygen Toxicity. Amsterdam: Elsevier.
119. Sen, C.K., Packer, L., and Hanninen, O. (2000) Handbook of Oxidants and Antioxidants in Exercise. Amsterdam: Elsevier.
120. Sinclair, A.J., Girling, A.J., Gray, L., Le-Guen, C., Lunec, J., and Barnett, A.H. (1991) Disturbed handling of ascorbic acid in diabetic patients with and without microangiopathy during high dose ascorbate supplementation. Diabetologia 34, 171-175.
121. Sinclair, A.J., Girling, A.J., Gray, L., Lunec, J., and Barnett, A.H. (1992) An investigation of the relationship between free radical activity and vitamin C metabolism in elderly diabetic subjects with retinopathy. Gerontology 38, 268-274.
122. Skrha, J., Hodinar, A., Kvasnicka, J., Stibor, V., Sperl, M., Stolba, P., and Hilgertova, J. (1994) Early changes of serum N-acetyl-beta-glucosaminidase, tissue plasminogen activator and erythrocyte superoxide dismutase in relation to retinopathy in type 1 diabetes mellitus. Clinica Chimica Acta 229, 5-14.
123. Stahlberg, M.R., and Hietanen, E. (1991) Glutathione and glutathione-metabolizing enzymes in the erythrocytes of healthy children and in children with insulin-dependent diabetes mellitus, juvenile rheumatoid arthritis, coeliac disease and acute lymphoblastic leukaemia. Scandinavian Journal of Clinical and Laboratory Investigation 51, 125-130.
124. Sundaram, R.K., Bhaskar, A., Vijayalingam, S., Viswanathan, M., Mohan, R., and Shanmugasundaram, K.R. (1996) Antioxidant status and lipid peroxidation in type II diabetes mellitus with and without complications. Clinical Science 90, 255-260.
125. Telci, A., Cakatay, U., Salman, S., Satman, I., and Sivas, A. (2000) Oxidative protein damage in early stage Type 1 diabetic patients. Diabetes Res Clin Pract 50, 213-223.
126. Tesfamariam, B. (1994) Free Radicals in Diabetic Endothelial Cell Dysfunction. Free Radical Biology and Medicine 16, 383-391.
127. Tho, L.L., and Candlish, J.K. (1987) Superoxide dismutase and glutathione peroxidase activities in erythrocytes as indices of oxygen loading in disease: a survey of one hundred cases. Biochemical Medicine and Metabolic Biology 38, 74-80.
128. Tho, L.L., Candlish, J.K., and Thai, A.C. (1988) Correlates of diabetes markers with erythrocytic enzymes decomposing reactive oxygen species. Annals of Clinical Biochemistry 25, 426-431.
129. Thornalley, P.J., McLellan, A.C., Lo, T.W., Benn, J., and Sonksen, P.H. (1996) Negative association between erythrocyte reduced glutathione concentration and diabetic complications. Clinical Science 91, 575-582.
130. Tiidus, P.M., Pushkarenko, J., and Houston, M.E. (1996) Lack of antioxidant adaptation to short-term aerobic training in human muscle. The American Journal of Physiology 271, R832-836.
131. Tsai, E.C., Hirsch, I.B., Brunzell, J.D., and Chait, A. (1994) Reduced plasma peroxyl radical trapping capacity and increased susceptibility of LDL to oxidation in poorly controlled IDDM. Diabetes 43, 1010-1014.
132. Urano, S., Hoshi Hashizume, M., Tochigi, N., Matsuo, M., Shiraki, M., and Ito, H. (1991) Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics. Lipids 26, 58-61.
133. Uusitupa, M.I., Niskanen, L., Luoma, J., Vilja, P., Mercuri, M., Rauramaa, R., and Yla Herttuala, S. (1996) Autoantibodies against oxidized LDL do not predict atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus. Arteriosclerosis, Thrombosis, and Vascular Biology 16, 1236-1242.
134. Walter, R.M., Jr., Uriu Hare, J.Y., Olin, K.L., Oster, M.H., Anawalt, B.D., Critchfield, J.W., and Keen, C.L. (1991) Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care 14, 1050-1056.
135. Van Dam, P.S., Van Asbeck, B.S., Erkelens, D.W., Marx, J.J.M., Gispen, W.-H., and Bravenboer, B. (1995) The role of oxidative stress in neuropathy and other diabetic complications. Diabetes/Metabolism Reviews 11, 181-192.
136. Watala, C., and Winocour, P.D. (1992) The relationship of chemical modification of membrane proteins and plasma lipoproteins to reduced membrane fluidity of erythrocytes from diabetic subjects. European Journal of Clinical Chemistry and Clinical Biochemistry 30, 513-519.
137. Velazquez, E., Winocour, P.H., Kesteven, P., Alberti, K.G., and Laker, M.F. (1991) Relation of lipid peroxides to macrovascular disease in type 2 diabetes. Diabetic Medicine 8, 752-758.
138. Vijayalingam, S., Parthiban, A., and Shanmugasundaram, K.R., Mohan, V. (1996) Abnormal antioxidant status in impaired glucose tolerance and non-insulin-dependent diabetes mellitus. Diabetic Medicine 13, 715-719.
139. Wolff, S.P., Jiang, Z.Y., and Hunt, J.V. (1991) Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radical Biology and Medicine 10, 339-352.
140. Yagi, K. (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochemical Medicine 15, 212-216.
141. Yaqoob, M., McClelland, P., Patrick, A.W., Stevenson, A., Mason, H., White, M.C., and Bell, G.M. (1994) Evidence of oxidant injury and tubular damage in early diabetic nephropathy. Q. J. Med. 87, 601-607.
142. Yoshida, K., Hirokawa, J., Tagami, S., Kawakami, Y., Urata, Y., and Kondo, T. (1995) Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux. Diabetologia 38, 201-210.
143. Zimmet, P., and Lefebvre, P. (1996) The global NIDDM epidemic. Treating the disease and ignoring the symptom [editorial]. Diabetologia. 39, 1247-1248.
144. Zimmet, P.Z., McCarty, D.J., and de Courten, M.P. (1997) The global epidemiology of non-insulin-dependent diabetes mellitus and the metabolic syndrome. Journal of Diabetes and its Complications 11, 60-68.
145. Zoppini, G., Targher, G., Monauni, T., Faccini, G., Pasqualini, E., Martinelli, C., Zenari, M.L., and Muggeo, M. (1996) Increase in circulating products of lipid peroxidation in smokers with IDDM. Diabetes Care 19, 1233-1236.