A low-glycemic index diet and exercise intervention reduces TNFα in isolated mononuclear cells of older, obese adults

Journal of Nutrition

Volumn 141, Issue 6, 2011, Pages 1089-1094

  Kelly, Karen R ^a,b,c   Haus, Jacob M ^a,b   Solomon, Thomas P J ^a   Patrick Melin, Aimee J ^a   Cook, Marc ^a   Rocco, Michael ^a   Barkoukis, Hope ^b   Kirwan, John P ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NAVAL MEDICAL CENTER SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AEROBIC EXERCISE; AGED; ARTICLE; BLOOD SAMPLING; CARBOHYDRATE INTAKE; CLINICAL ARTICLE; CYTOKINE RELEASE; DIET; FAT INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCEMIC INDEX; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; OBESITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BLOOD LEVEL; PROTEIN INTAKE;

AGED; BLOOD GLUCOSE; BODY COMPOSITION; CHEMOKINE CCL2; COMBINED MODALITY THERAPY; DIABETES MELLITUS, TYPE 2; DIET; EXERCISE THERAPY; FEMALE; GLYCEMIC INDEX; HUMANS; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MALE; OBESITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79958185454     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.139964     Document Type: Article

References (49)

1. Heilbronn LK, Campbell LV. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des. 2008;14:1225-30.
2. Kohrt WM, Kirwan JP, Staten MA, Bourey RE, King DS, Holloszy JO. Insulin resistance in aging is related to abdominal obesity. Diabetes. 1993;42:273-81.
3. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in he Framingham Heart Study. Circulation. 1983; 67:968-77.
4. Gonzalez F, Minium J, Rote NS, Kirwan JP. Altered tumor necrosis factor alpha release from mononuclear cells of obese reproductive-age women during yperglycemia. Metabolism. 2006;55:271-6.
5. Gonzalez F, Minium J, Rote NS, Kirwan JP. Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic vary syndrome. J Clin Endocrinol Metab. 2005;90: 5336-42.
6. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-a in human obesity and nsulin resistance. J Clin Invest. 1995;95:2409-15.
7. Frost G, Leeds A, Trew G. Insulin sensitivity in women at risk of coronary heart disease and the effect of a low glycemic index diet. Metabolism. 998;47:1245-51.
8. Jarvi AE, Karlstrom BE, Granfeldt YE, Bjorck IE, Asp NG, Vessby BO. Improved glycemic control and lipid profile and normalized fibrolytic activity on a low-glycemic index diet in type 2 diabetic patients. Diabetes Care. 1999;22:10-8.
9. Jenkins DJ, Kendall CW, McKeown-Eyssen G, Josse RG, Silverberg J, Booth GL, Vidgen E, Josse AR, Nguyen TH, et al. Effect of a lowglycemic index or a high-cereal fiber diet on type 2 diabetes: a randomized trial. JAMA. 2008;300:2742-53.
10. Kirwan JP, Barkoukis H, Brooks LM, Marchetti CM, Stetzer BP, Gonzalez F. Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults. Ann Nutr Metab. 2009;55:326-33.
11. Kallio P, Kolehmainen M, Laaksonen DE, Pulkkinen L, Atalay M, Mykkanen H, Uusitupa M, Poutanen K, Niskanen L. Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome. Am J Clin Nutr. 2008;87:1497-503.
12. Qi L, van Dam RM, Liu S, Franz M, Mantzoros C, Hu FB. Wholegrain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic omen. Diabetes Care. 2006;29:207-11.
13. Hartman TJ, Albert PS, Zhang Z, Bagshaw D, Kris-Etherton PM, Ulbrecht J, Miller CK, Bobe G, Colburn NH, et al. Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer. J Nutr. 2010;140:60-7.
14. Botero D, Ebbeling CB, Blumberg JB, Ribaya-Mercado JD, Creager MA, Swain JF, Feldman HA, Ludwig DS. Acute effects of dietary glycemic index on antioxidant capacity in a nutrient-controlled feeding study. Obesity (Silver Spring). 2009;17:1664-70.
15. Wolever TM, Brand-Miller JC, Abernethy J, Astrup A, Atkinson F, Axelsen M, Bjorck I, Brighenti F, Brown R, et al. Measuring the glycemic index of oods: interlaboratory study. Am J Clin Nutr. 2008;87:S247-57.
16. Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2004;52:1098-104.
17. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisuretime physical activity and reduced plasma levels of obesity-related inflammatory arkers. Obes Res. 2003;11:1055-64.
18. Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, Moussa A, et al. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res. 2003;11:1048-54.
19. Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of eveloping ischemic heart disease. JAMA. 1999;281:1722-7.
20. Taylor HL, Jacobs JDR, Schucker B, Knudsen J, Leon AS, Debacker G. A questionnaire for the assessment of leisure time physical activities. J Chronic Dis. 978;31:741-55.
21. Weir JBV. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol. 1949;109:1-9.
22. Solomon TP, Haus JM, Kelly KR, Cook M, Watanabe R, Barkoukis H, Kirwan JP. A low glycemic index diet combined with exercise reduces insulin resistance and suppresses compensatory hyperinsulinemia and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans. Am J Clin Nutr. 010;92:1359-68.
23. O'Leary VB, Marchetti CM, Krishnan RK, Stetzer BP, Gonzalez F, Kirwan JP. Exercise-induced reversal of insulin resistance in obese elderly is associated ith reduced visceral fat. J Appl Physiol. 2006;100:1584-9.
24. Kirwan JP, Krishnan RK, Weaver JA, del Aguila LF, Evans WJ. Human aging is associated with altered TNF-a production during hyperglycemia and hyperinsulinemia. Am J Physiol Endocrinol Metab. 2001;281: E1137-43.
25. Solomon TP, Haus JM, Kelly KR, Cook MD, Riccardi M, Rocco M, Kashyap SR, Barkoukis H, Kirwan JP. Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans. Am J Clin Nutr. 2009;90:1222-9.
26. Beulens JW, de Bruijne LM, Stolk RP, Peeters PH, Bots ML, Grobbee DE, van der Schouw YT. High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women: a population-based follow-up study. J Am Coll Cardiol. 2007;50:14-21.
27. Schulze MB, Liu S, Rimm EB, Manson JE, Willett WC, Hu FB. Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am J Clin Nutr. 2004;80:348-56.
28. Riccardi G, Rivellese AA, Giacco R. Role of glycemic index and glycemic load in the healthy state, in prediabetes, and in diabetes. Am J Clin Nutr. 008;87:S269-74.
29. Kelly KR, Brooks LM, Solomon TP, Kashyap SR, O'Leary VB, Kirwan JP. The glucose-dependent insulinotropic polypeptide and glucosestimulated insulin response to exercise training and diet in obesity. Am J Physiol Endocrinol Metab. 2009;296:E1269-74.
30. Mohanty P, Hamouda W, Garg R, Aljada A, Ghanim H, Dandona P. Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes. J lin Endocrinol Metab. 2000;85:2970-3.
31. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr ev. 2002;23:599-622.
32. Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation. 004;110:1564-71.
33. Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord. 2003;27 Suppl 3:S53-5.
34. Perseghin G, Petersen K, Shulman GI. Cellular mechanism of insulin resistance: potential links with inflammation. Int J Obes Relat Metab Disord. 2003;27 uppl 3:S6-11.
35. Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002;106:2067-72.
36. Morohoshi M, Fujisawa K, Uchimura I, Numano F. Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood onocytes in vitro. Diabetes. 1996;45:954-9.
37. Bastard JP, Maachi M, Van Nhieu JT, Jardel C, Bruckert E, Grimaldi A, Robert JJ, Capeau J, Hainque B. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab. 2002;87:2084-9.
38. Kern PA, Ranganathan S, Li C,Wood L, Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2001;280: E745-51.
39. Pedersen M, Bruunsgaard H, Weis N, Hendel HW, Andreassen BU, Eldrup E, Dela F, Pedersen BK. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev. 2003;124:495-502.
40. Karastergiou K, Mohamed-Ali V. The autocrine and paracrine roles of adipokines. Mol Cell Endocrinol. 2010;318:69-78.
41. Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem. 2003;278:45777-84.
42. Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J, Caron M. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun. 2003;311:372-9.
43. Christiansen T, Paulsen SK, Bruun JM, Pedersen SB, Richelsen B. Exercise-training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects. A 12-week randomized intervention-study. Am J Physiol Endocrinol Metab. 2010;298: E824-31.
44. Dekker MJ, Lee S, Hudson R, Kilpatrick K, Graham TE, Ross R, Robinson LE. An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism. 2007;56:332-8.
45. Baggiolini M. Chemokines and leukocyte traffic. Nature. 1998;392: 565-8.
46. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during dietinduced obesity. iabetes. 2007;56:16-23.
47. Sell H, Dietze-Schroeder D, Kaiser U, Eckel J. Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and keletal muscle. Endocrinology. 2006;147:2458-67.
48. Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci USA. 2003;100:7265-70.
49. Vrolix R, Mensink RP. Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome. Am J Clin Nutr. 010;92:366-74.