Metformin and exercise in type 2 diabetes: Examining treatment modality interactions

Diabetes Care

Volumn 34, Issue 7, 2011, Pages 1469-1474

  Boulé, Normand G ^a   Robert, Cheri ^a   Bell, Gordon J ^a   Johnson, Steven T ^b   Bell, Rhonda C ^a   Lewanczuk, Richard Z ^a   Gabr, Raniah Q ^a   Brocks, Dion R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ATHABASCA UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCAGON; INSULIN; LACTIC ACID; METFORMIN; PLACEBO; ANTIDIABETIC AGENT; LACTIC ACID DERIVATIVE;

ABDOMINAL DISCOMFORT; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFICACY; ENERGY EXPENDITURE; EXERCISE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCAGON BLOOD LEVEL; HEART RATE; HORMONE RESPONSE; HUMAN; INSULIN BLOOD LEVEL; LACTATE BLOOD LEVEL; LUNG GAS EXCHANGE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXYGEN CONSUMPTION; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; GLUCOSE BLOOD LEVEL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

BLOOD GLUCOSE; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; EXERCISE; HEART RATE; HUMANS; HYPOGLYCEMIC AGENTS; LACTATES; METFORMIN;

EID: 80054709283     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc10-2207     Document Type: Article

References (25)

1. 2009 Top 200 generic drugs by total prescriptions. Drug Topics 2010:1-3
2. Nathan DM, Buse JB, Davidson MB, et al. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2006;29:1963-1972 (Pubitemid 44156663)
3. Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD, Vijay V; Indian Diabetes Prevention Programme (IDPP). The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia 2006; 49:289-297 (Pubitemid 43185397)
4. Sharoff CG, Hagobian TA, Malin SK, et al. Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals. Am J Physiol Endocrinol Metab 2010;298:E815-E823
5. Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001;108: 1167-1174 (Pubitemid 32995375)
6. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell 2008;134:405-415
7. Jadhav S, Ferrell W, Greer IA, Petrie JR, Cobbe SM, Sattar N. Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study. J Am Coll Cardiol 2006;48:956-963 (Pubitemid 44292455)
8. Boulé NG, Weisnagel SJ, Lakka TA, et al.; HERITAGE Family Study. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care 2005;28:108-114 (Pubitemid 40095791)
9. American College of Sports Medicine; American Diabetes Association. Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and type 2 diabetes. Med Sci Sports Exerc 2010;42:2282-2303
10. Johnson ST, Tudor-Locke C, McCargar LJ, Bell RC. Measuring habitual walking speed of people with type 2 diabetes: are they meeting recommendations? Diabetes Care 2005;28:1503-1504 (Pubitemid 40756725)
11. Gabr RQ, Padwal RS, Brocks DR. Determination of metformin in human plasma and urine by high-performance liquid chromatography using small sample volume and conventional octadecyl silane coloumn. J Pharm Pharm Sci 2010;13:486-494
12. Pereira MA, Fitzer Gerald SJ, Gregg EW, et al. A collection of Physical Activity Questionnaires for health-related research. Med Sci Sports Exerc 1997;29(Suppl.):S1-S205
13. Johnson ST, Robert C, Bell GJ, Bell RC, Lewanczuk RZ, Boulé NG. Acute effect of metformin on exercise capacity in active males. Diabetes Obes Metab 2008;10: 747-754
14. Cunha MR, da Silva ME, Machado HA, et al. The effects of metformin and glibenclamide on glucose metabolism, counter-regulatory hormones and cardiovascular responses in women with type 2 diabetes during exercise of moderate intensity. Diabet Med 2007;24:592-599 (Pubitemid 46823172)
15. Cunha MR, Silva ME, Machado HA, et al. Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide. Diabetes Obes Metab 2008;10: 238-245 (Pubitemid 351247340)
16. Musi N, Hirshman MF, Nygren J, et al. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 2002;51:2074-2081 (Pubitemid 34729010)
17. Armstrong RB, Hayes DA, Delp MD. Blood flow distribution in rat muscles during preexercise anticipatory response. J Appl Physiol 1989;67:1855-1861 (Pubitemid 20039393)
18. Khazaeinia T, Ramsey AA, Tam YK. The effects of exercise on the pharmacokinetics of drugs. J Pharm Pharm Sci 2000;3: 292-302
19. Ferland A, Brassard P, Lemieux S, et al. Impact of high-fat/low- carbohydrate, high-, low-glycaemic index or low-caloric meals on glucose regulation during aerobic exercise in type 2 diabetes. Diabet Med 2009;26: 589-595
20. Poirier P, Mawhinney S, Grondin L, et al. Prior meal enhances the plasma glucose lowering effect of exercise in type 2 diabetes. Med Sci Sports Exerc 2001;33: 1259-1264 (Pubitemid 32729839)
21. Kjaer M, Hollenbeck CB, Frey-Hewitt B, Galbo H, Haskell W, Reaven GM. Glucoregulation and hormonal responses to maximal exercise in non-insulin-dependent diabetes. J Appl Physiol 1990;68:2067-2074 (Pubitemid 20183098)
22. Larsen JJ, Dela F, Madsbad S, Galbo H. The effect of intense exercise on post-prandial glucose homeostasis in type II diabetic patients. Diabetologia 1999;42: 1282-1292 (Pubitemid 29500964)
23. Dunning BE, Gerich JE. The role of alpha-cell dysregulation in fasting and post-prandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 2007;28:253-283 (Pubitemid 46984828)
24. Jackson RA, Hawa MI, Jaspan JB, et al. Mechanism of metformin action in non-insulin-dependent diabetes. Diabetes 1987; 36:632-640 (Pubitemid 18024740)
25. Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 1995;333: 550-554