Arterial H+ regulation during exercise in humans

Respiratory Physiology and Neurobiology

Volumn 178, Issue 2, 2011, Pages 191-195

  Wasserman, Karlman ^a   Beaver, William L ^a   Sun, Xing Guo ^a   Stringer, William W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Arterial chemoreceptors; Exercise; H+ regulation; Lactic acidosis threshold; Respiratory and metabolic H+ species; Ventilatory compensation point

Indexed keywords

HYDROGEN;

ACCURACY; ADULT; AEROBIC METABOLISM; AIR CONDITIONING; ARTERIAL CIRCULATION; ARTERIAL OXYGEN SATURATION; ARTICLE; BLOOD OXYGEN TENSION; BREATHING; EXERCISE; HUMAN; HUMAN EXPERIMENT; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS THRESHOLD; MALE; NORMAL HUMAN; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; RESPIRATORY FUNCTION; VENTILATORY COMPENSATION POINT; WORK CAPACITY;

ACIDOSIS, LACTIC; ADOLESCENT; ARTERIES; BLOOD GAS ANALYSIS; EXERCISE; HUMANS; HYDROGEN-ION CONCENTRATION; PULMONARY VENTILATION; YOUNG ADULT;

EID: 80052373419     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2011.05.018     Document Type: Article

References (28)

1. Barr P.O., Beckman M., Bjurstedt H., Brismar J., Hesser C.M., Matell G. Time courses of blood gas changes provoked by light and moderate exercise in man. Acta Physiol. Scand. 1964, 60:1-17.
2. Beaver W.L., Lamarra N., Wasserman K. Breath-by-breath measurement of true alveolar gas exchange. J. Appl. Physiol. 1981, 51:1662-1675.
3. Beaver W.L., Wasserman K., Whipp B.J. A new method for detecting anaerobic threshold by gas exchange. J. Appl. Physiol. 1986, 60:2020-2027.
4. Beaver W.L., Wasserman K., Whipp B.J. Bicarbonate buffering of lactic acid generated during exercise. J. Appl. Physiol. 1986, 60:472-478.
5. Berger A.J., Mitchell R.W., Severinghaus J.W. Regulation of respiration. N. Engl. J. Med. 1977, 297:92-97.
6. Casaburi R., Whipp B.J., Wasserman K., Beaver W.L., Koyal S.N. Ventilatory and gas exchange dynamics in response to sinusoidal work. J. Appl. Physiol. 1977, 42:300-301.
7. Casaburi R., Whipp B.J., Wasserman K., Stremel R.W. Ventilatory control characteristics of the exercise hyperpnea as discerned from dynamic forcing techniques. Chest 1978, 73:280-283.
8. Davidson J.T., Whipp B.J., Wasserman K., Koyal S.N., Lugliani R. Role of the carotid bodies in breath-holding. N. Engl. J. Med. 1974, 290:819-822.
9. Dejours P. Control of respiration in muscular exercise. Handbook of Physiology 1964, 631-638. American Physiological Society, Washington, D.C. W.O. Fenn, H. Rahn (Eds.).
10. Diamond L.B., Casaburi R., Wasserman K., Whipp B.J. Kinetics of gas exchange and ventilation in transitions from rest or prior exercise. J. Appl. Physiol. 1977, 43:704-708.
11. Itoh H., Kato K. Short-term exercise training after cardiac surgery. Exercise Gas Exchange in Heart Disease 1996, 229-244. Futura Publishing Company, Armonk, NY. K. Wasserman (Ed.).
12. Lahiri S., Forster R.E. CO2/H(+) sensing: peripheral and central chemoreception. Int. J. Biochem. Cell Biol. 2003, 35:1413-1435.
13. Lugliani R., Whipp B.J., Seard C., Wasserman K. Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man. N. Engl. J. Med. 1971, 285:1105-1111.
14. Poon C.S., Tin C., Yu Y. Homeostasis of exercise hyperpnea and optimal sensorimotor integration: the internal model paradigm. Respir. Physiol. Neurobiol. 2007, 159:1-13.
15. Rausch S.M., Whipp B.J., Wasserman K., Huszczuk A. Role of the carotid bodies in the respiratory compensation for the metabolic acidosis of exercise in humans. J. Physiol. 1991, 444:567-578.
16. Scheuermann B.W., Kowalchuk J.M. Attenuated respiratory compensation during rapidly incremented ramp exercise. Respir. Physiol. 1998, 114:227-238.
17. Sietsema K.E., Cooper D.M., Perloff J.K., Child J.S., Rosove M.H., Wasserman K., Whipp B.J. Control of ventilation during exercise in patients with central venous-to-systemic arterial shunts. J. Appl. Physiol. 1988, 64:234-242.
18. Snedecor C.W., Cochran W.G. Statistical Methods 1980, Iowa.
19. Stringer W., Casaburi R., Wasserman K. Acid-base regulation during exercise and recovery in humans. J. Appl. Physiol. 1992, 72:954-961.
20. Sun X.G., Hansen J.E., Garatachea N., Storer T.W., Wasserman K. Ventilatory efficiency during exercise in healthy subjects. Am. J. Respir. Crit. Care Med. 2002, 166:1443-1448.
21. Sun X.G., Hansen J.E., Stringer W.W., Ting H., Wasserman K. Carbon dioxide pressure-concentration relationship in arterial and mixed venous blood during exercise. J. Appl. Physiol. 2001, 90:1798-1810.
22. Wasserman K., Hansen H., Sue D., Stringer W., Whipp B. Principles of Exercise Testing and Interpretation 2005, Lippincott Williams & Wilkins, Philadephia.
23. Wasserman K., Stringer W.W., Casaburi R., Zhang Y.Y. Mechanism of the exercise hyperkalemia: an alternate hypothesis. J. Appl. Physiol. 1997, 83:631-643.
24. Wasserman K., Van Kessel A.L., Burton G.G. Interaction of physiological mechanisms during exercise. J. Appl. Physiol. 1967, 22:71-85.
25. Wasserman K., Whipp B.J., Casaburi R. Respiratory control during exercise. Handbook of Physiology 1986, vol. 2:595-619. American Physiological Society, Bethesda.
26. Wasserman K., Whipp B.J., Koyal S.N., Beaver W.L. Anaerobic threshold and respiratory gas exchange during exercise. J. Appl. Physiol. 1973, 35:236-243.
27. Wasserman K., Whipp B.J., Koyal S.N., Cleary M.G. Effect of carotid body resection on ventilatory and acid-base control during exercise. J. Appl. Physiol. 1975, 39:354-358.
28. Whipp B.J., Wasserman K., Casaburi R., Juratsch C.E., Weissman M.L., Stremel R.W. Ventilatory control characteristics of conditions resulting in isocapnic hyperpnea. Adv. Exp. Med. Biol. 1978, 99:355-365.