Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death

BMC Cell Biology

Volumn 16, Issue 1, 2015, Pages

  Shubin, Andrey V ^a   Demidyuk, Ilya V ^a   Lunina, Nataliya A ^a   Komissarov, Alexey A ^a   Roschina, Marina P ^a   Leonova, Olga G ^b   Kostrov, Sergey V ^a,c  

^a INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

^b ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^c KURCHATOV INSTITUTE   (Russian Federation)

Author keywords

3C protease; Caspase independent cell death; Cytoplasmic vacuolization; Hepatitis A virus

Indexed keywords

3C PROTEASE; BAFILOMYCIN A1; CASPASE; CASPASE INHIBITOR; CYSTEINE PROTEINASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PHOSPHATIDYLSERINE; PROTEIN RAB5; PROTEIN RAB9; PROTEIN RIP1 KINASE; PROTEINASE; RAB PROTEIN; RAB11 PROTEIN; RAB7 PROTEIN; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS PROTEIN; 3C PROTEASES; AGFG1 PROTEIN, HUMAN; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; GUANOSINE TRIPHOSPHATASE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MACROLIDE; NECROSTATIN-1; NUCLEOPORIN; PEPTIDE CHLOROMETHYL KETONE; RNA BINDING PROTEIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL FRACTIONATION; CELL ORGANELLE; CELL SURVIVAL; CELL VACUOLE; CYTOPLASM; CYTOTOXICITY; ENDOSOME; ENZYME MECHANISM; HEPATITIS A VIRUS; HUMAN; HUMAN CELL; LYSOSOME MEMBRANE; NONHUMAN; PICORNAVIRIDAE; PINOCYTOSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; TONOPLAST; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ELECTRON MICROSCOPY; ENZYMOLOGY; GENETICS; LYSOSOME; METABOLISM; MITOCHONDRION; TUMOR CELL LINE; ULTRASTRUCTURE;

HEPATITIS A VIRUS; HUMAN HEPATITIS A VIRUS;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; ENDOSOMES; GTP PHOSPHOHYDROLASES; HEPATITIS A VIRUS; HUMANS; IMIDAZOLES; INDOLES; LYSOSOMES; MACROLIDES; MICROSCOPY, ELECTRON; MITOCHONDRIA; NUCLEAR PORE COMPLEX PROTEINS; RNA-BINDING PROTEINS; VACUOLES; VIRAL PROTEINS;

EID: 84924910470     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/s12860-015-0050-z     Document Type: Article

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