Disruption of tlr3 signaling due to cleavage of trif by the hepatitis a virus protease-polymerase processing intermediate, 3cd

PLoS Pathogens

Volumn 7, Issue 9, 2011, Pages

  Qu, Lin ^a,d   Feng, Zongdi ^a   Yamane, Daisuke ^a   Liang, Yuqiong ^a   Lanford, Robert E ^b   Li, Kui ^c   Lemon, Stanley M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3CD PROTEIN; BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; UNCLASSIFIED DRUG; VIRUS PROTEIN; 3C PROTEASES; CYSTEINE PROTEINASE; IRF3 PROTEIN, HUMAN; LUCIFERASE; TICAM1 PROTEIN, HUMAN; TLR3 PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN; VIRUS RNA;

ARTICLE; CELL NUCLEUS; CELL STRAIN; CELL STRAIN HEK293; CONTROLLED STUDY; DIMERIZATION; GENE MUTATION; HEPATITIS A VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PROTEIN CLEAVAGE; PROTON TRANSPORT; SIGNAL TRANSDUCTION; CELL LINE; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; INNATE IMMUNITY; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; PLASMID;

HEPATITIS A VIRUS; PICORNAVIRIDAE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; CELL LINE; CYSTEINE ENDOPEPTIDASES; HEPATITIS A VIRUS; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; LUCIFERASES; PLASMIDS; RNA, VIRAL; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TOLL-LIKE RECEPTOR 3; TRANSFECTION; VIRAL PROTEINS;

EID: 79960598740     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002169     Document Type: Article

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