Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments

Journal of Peptide Science

Volumn 21, Issue 4, 2015, Pages 283-293

  Calvanese, Luisa ^a   Sandomenico, Annamaria ^a,b   Caporale, Andrea ^a   Focà, Annalia ^a,c   Focà, Giuseppina ^a,c   D'Auria, Gabriella ^a,b   Falcigno, Lucia ^a,b   Ruvo, Menotti ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c Bioker Multimedica   (Italy)

Author keywords

NMR; peptides; SPR, Nodal; TGF beta

Indexed keywords

ALANINE DERIVATIVE; CRIPTO MEMBRANE PROTEIN; EPITOPE; GLUTAMIC ACID; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PROTEIN NODAL; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE ALK4; PROTEIN SERINE THREONINE KINASE ALK7; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; ACTIVIN RECEPTOR 1; ACVR1B PROTEIN, HUMAN; ACVR1C PROTEIN, HUMAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; PEPTIDE; PROTEIN BINDING; SIGNAL PEPTIDE; TDGF1 PROTEIN, HUMAN; TUMOR PROTEIN;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; COMPLEX FORMATION; HUMAN; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; SURFACE PLASMON RESONANCE; WILD TYPE; CHEMISTRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING;

ACTIVIN RECEPTORS, TYPE I; CIRCULAR DICHROISM; GPI-LINKED PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNETIC RESONANCE IMAGING; MOLECULAR DOCKING SIMULATION; NEOPLASM PROTEINS; NODAL PROTEIN; PEPTIDES; PROTEIN BINDING; SURFACE PLASMON RESONANCE;

EID: 84924855600     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2733     Document Type: Article

References (48)

1. Jornvall H, Reissmann E, Andersson O, Mehrkash M, Ibanez CF,. ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol. Cell. Biol. 2004; 24: 9383-9389.
2. James D, Levine AJ, Besser D, Hemmati-Brivanlou A,. TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005; 132: 1273-1282.
3. Pantic I,. Cancer stem cell hypotheses: impact on modern molecular physiology and pharmacology research. J. Biosci. 2011; 36: 957-961.
4. Quail DF, Siegers GM, Jewer M, Postovit LM,. Nodal signalling in embryogenesis and tumourigenesis. Int. J. Biochem. Cell Biol. 2013; 45: 885-898.
5. Xu G, Zhong Y, Munir S, Yang BB, Tsang BK, Peng C,. Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. J. Clin. Endocrinol. Metab. 2004; 89: 5523-5534.
6. Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ, Heeschen C,. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007; 1: 313-323.
7. Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ruiz R, Garcia E, Hidalgo M, Cebrian DA, Heuchel R, Lohr M, Berger F, Bartenstein P, Aicher A, Heeschen, C,. Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. Cell Stem Cell 2011; 9: 433-446.
8. Papageorgiou I, Nicholls PK, Wang F, Lackmann M, Makanji Y, Salamonsen LA, Robertson DM, Harrison CA,. Expression of nodal signalling components in cycling human endometrium and in endometrial cancer. Reproductive Biol. Endocrinol.: RB&E 2009; 7: 122.
9. Quail DF, Walsh LA, Zhang G, Findlay SD, Moreno J, Fung L, Ablack A, Lewis JD, Done SJ, Hess DA, Postovit LM,. Embryonic protein nodal promotes breast cancer vascularization. Cancer Res. 2012; 72: 3851-3863.
10. Strizzi L, Hardy KM, Margaryan NV, Hillman DW, Seftor EA, Chen B, Geiger XJ, Thompson EA, Lingle WL, Andorfer CA, Perez EA, Hendrix MJ,. Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer. Breast Canc. Res.: BCR 2012; 14: R75.
11. Kirsammer G, Strizzi L, Margaryan NV, Gilgur A, Hyser M, Atkinson J, Kirschmann DA, Seftor EA, Hendrix MJ,. Nodal signaling promotes a tumorigenic phenotype in human breast cancer. Semin. Cancer Biol. 2014.
12. Vo BT, Cody B, Cao Y, Khan SA,. Differential role of Sloan-Kettering Institute (Ski) protein in Nodal and transforming growth factor-beta (TGF-beta)-induced Smad signaling in prostate cancer cells. Carcinogenesis 2012; 33: 2054-2064.
13. Lawrence MG, Margaryan NV, Loessner D, Collins A, Kerr KM, Turner M, Seftor EA, Stephens CR, Lai J, Postovit LM, Clements JA, Hendrix MJ,. Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate 2011; 71: 1198-1209.
14. Spiller CM, Bowles J, Koopman P,. Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors. Int. J. Dev. Biol. 2013; 57: 211-219.
15. Lee CC, Jan HJ, Lai JH, Ma HI, Hueng DY, Lee YC, Cheng YY, Liu LW, Wei HW, Lee HM,. Nodal promotes growth and invasion in human gliomas. Oncogene 2010; 29: 3110-3123.
16. Tysnes BB, Satran HA, Mork SJ, Margaryan NV, Eide GE, Petersen K, Strizzi L, Hendrix MJ,. Age-dependent association between protein expression of the embryonic stem cell marker Cripto-1 and survival of glioblastoma patients. Translational oncology 2013; 6: 732-741.
17. Gong Y, Yu T, Chen B, He M, Li Y,. Removal of cardiopulmonary resuscitation artifacts with an enhanced adaptive filtering method: an experimental trial. BioMed Res. Int. 2014; 2014: 140438.
18. Seftor EA, Seftor RE, Weldon DS, Kirsammer GT, Margaryan NV, Gilgur A, Hendrix MJ,. Melanoma tumor cell heterogeneity: a molecular approach to study subpopulations expressing the embryonic morphogen nodal. Semin. Oncol. 2014; 41: 259-266.
19. Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J, Hendrix MJ,. Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat. Med. 2006; 12: 925-932.
20. Chen J, Liu WB, Jia WD, Xu GL, Ma JL, Ren Y, Chen H, Sun SN, Huang M, Li JS,. Embryonic morphogen nodal is associated with progression and poor prognosis of hepatocellular carcinoma. PLoS One 2014; 9: e85840.
21. Ganapathy V, Ge R, Grazioli A, Xie W, Banach-Petrosky W, Kang Y, Lonning S, McPherson J, Yingling JM, Biswas S, Mundy GR, Reiss M,. Targeting the transforming growth factor-beta pathway inhibits human basal-like breast cancer metastasis. Mol. Cancer 2010; 9: 122.
22. Korpal M, Kang Y,. Targeting the transforming growth factor-beta signalling pathway in metastatic cancer. Eur. J. Cancer 2010; 46: 1232-1240.
23. Strizzi L, Hardy KM, Kirschmann DA, Ahrlund-Richter L, Hendrix MJ,. Nodal expression and detection in cancer: experience and challenges. Cancer Res. 2012; 72: 1915-1920.
24. Wakefield LM, Hill CS,. Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer. Nat. Rev. Cancer 2013; 13: 328-341.
25. Reissmann E, Jornvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, Persico MG, Ibanez CF, Brivanlou AH,. The orphan receptor ALK7 and the activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes Dev. 2001; 15: 2010-2022.
26. Schier AF, Shen MM,. Nodal signalling in vertebrate development. Nature 2000; 403: 385-389.
27. Yeo C, Whitman M,. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol. Cell 2001; 7: 949-957.
28. Minchiotti G, Manco G, Parisi S, Lago CT, Rosa F, Persico MG,. Structure-function analysis of the EGF-CFC family member Cripto identifies residues essential for nodal signalling. Development 2001; 128: 4501-4510.
29. Khalkhali-Ellis Z, Kirschmann DA, Seftor EA, Gilgur A, Bodenstine TM, Hinck AP, Hendrix MJ,. Divergence(s) in nodal signaling between aggressive melanoma and embryonic stem cells. Int. J. Canc. J. Int. du Canc. 2014.
30. Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L,. Structural investigations on the Nodal-Cripto binding: a theoretical and experimental approach. Biopolymers 2010; 93: 1011-1021.
31. Romano V, Raimondo D, Calvanese L, D'Auria G, Tramontano A, Falcigno L,. Toward a better understanding of the interaction between TGF-beta family members and their ALK receptors. J. Mol. Model. 2012; 18: 3617-3625.
32. Lin SJ, Lerch TF, Cook RW, Jardetzky TS, Woodruff TK,. The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. Reproduction 2006; 132: 179-190.
33. Greenwald J, Vega ME, Allendorph GP, Fischer WH, Vale W, Choe S,. A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors. Mol. Cell 2004; 15: 485-489.
34. Muenster U, Korupolu R, Rastogi R, Read J, Fischer WH,. Antagonism of activin by activin chimeras. Vitam. Horm. 2011; 85: 105-128.
35. Thompson TB, Woodruff TK, Jardetzky TS,. Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions. Embo. J. 2003; 22: 1555-1566.
36. Fields GB, Noble RL,. Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids. Int. J. Pept. Protein Res. 1990; 35: 161-214.
37. Bax A, Davis DG,. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy. J. Magn. Res. 1985; 65: 355-360.
38. States D, Haberhorn R, Ruben D,. A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants. J. Magn. Res. 1982; 48: 286-292.
39. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A,. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 1995; 6: 277-293.
40. Johnson BA,. Using NMRView to visualize and analyze the NMR spectra of macromolecules. Methods Mol. Biol. 2004; 278: 313-352.
41. Guntert P, Braun W, Wuthrich K,. Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA. J. Mol. Biol. 1991; 217: 517-530.
42. Guntert P, Mumenthaler C, Wuthrich K,. Torsion angle dynamics for NMR structure calculation with the new program DYANA. J. Mol. Biol. 1997; 273: 283-298.
43. Guntert P,. Automated NMR structure calculation with CYANA. Methods Mol. Biol. 2004; 278: 353-378.
44. Pearlman DA, Case DA, Caldwell JW, Ross WS, Cheatham TE III, DeBolt S, Ferguson D, Seibel G, Kollman P,. AMBER, a package of computer program for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules. Comp. Phys. Commun. 1995; 91: 1-41.
45. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE,. UCSF Chimera-a visualization system for exploratory research and analysis. J. Comput. Chem. 2004; 25: 1605-1612.
46. Koradi R, Billeter M, Wuthrich K,. MOLMOL: a program for display and analysis of macromolecular structures. J. Mol. Graph. 1996; 14: 51-55, 29-32.
47. Wuthrich K,. NMR of Proteins and Nucleic Acids, Wiley: New York, 1986.
48. Wishart DS, Sykes BD, Richards FM,. Relationship between nuclear magnetic resonance chemical shift and protein secondary structure. J. Mol. Biol. 1991; 222: 311-333.