Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease

Toxicological Sciences

Volumn 143, Issue 2, 2015, Pages 360-373

  De Miranda, Briana R ^a   Popichak, Katriana A ^a   Hammond, Sean L ^a   Miller, James A ^a   Safe, Stephen ^b,c   Tjalkens, Ronald B ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Microglia; Neuroinflammation; Orphan nuclear receptors; Parkinson's disease

Indexed keywords

1,1 BIS(3' INDOLYL) 1 (4 CHLOROPHENYL)METHANE; 1,1 BIS(3' INDOLYL) 1 (4 HYDROXYPHENYL)METHANE; 1,1 BIS(3' INDOLYL) 1 (4 METHOXYPHENYL)METHANE; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CHEMOKINE; CYTOKINE; INDOLYLMETHANE DERIVATIVE; NUCLEAR RECEPTOR NR4A3; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; 1,1-BIS(3'-INDOLYL)-1-(4-CHLOROPHENYL)METHANE; 1,1-BIS(3'-INDOLYL)-1-(4-HYDROXYPHENYL)METHANE; 1,1-BIS(3'-INDOLYL)-1-(P-ANISYL)METHANE; ANISOLE DERIVATIVE; ANTIPARKINSON AGENT; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLE DERIVATIVE; PHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GLIA CELL; MICROGLIA; MOUSE; MOUSE MODEL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA PARS COMPACTA; ANIMAL; ANIMAL BEHAVIOR; CELL COUNT; CHEMISTRY; DRUG EFFECTS; GENETICS; GLIA; METABOLISM; MPTP POISONING; PATHOLOGY; TRANSGENIC MOUSE;

MUS; ZEA MAYS;

ANIMALS; ANISOLES; ANTIPARKINSON AGENTS; BEHAVIOR, ANIMAL; CELL COUNT; DOPAMINERGIC NEURONS; GREEN FLUORESCENT PROTEINS; INDOLES; MICE, TRANSGENIC; MPTP POISONING; NEUROGLIA; NF-KAPPA B; PARKINSON DISEASE; PHENOLS;

EID: 84924712979     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu236     Document Type: Article

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