Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells

Molecular Endocrinology

Volumn 28, Issue 10, 2014, Pages 1729-1739

  Lee, Syng Ook ^a   Li, Xi ^b   Hedrick, Erik ^c   Jin, Un Ho ^d   Tjalkens, Ronald B ^e   Backos, Donald S ^f   Li, Li ^g   Zhang, Yi ^g   Wu, Qiao ^g   Safe, Stephen ^c,d  

^a Keimyung University   (South Korea)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^e Department of Environmental and Radiological Health Sciences   (United States)

^f UNIVERSITY OF COLORADO   (United States)

^g XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 BIS(3' INDOLYL) 1 (P HYDROXYPHENYL)METHANE; 3,3' DIINDOLYLMETHANE; ANTINEOPLASTIC AGENT; BETA ACTIN; CASPASE 3; CASPASE 7; DIMETHYL SULFOXIDE; LUCIFERASE; MAMMALIAN TARGET OF RAPAMYCIN; NUCLEAR RECEPTOR NUR77; SMALL INTERFERING RNA; SURVIVIN; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; 1,1-BIS(3'-INDOLYL)-1-(4-HYDROXYPHENYL)METHANE; INDOLE DERIVATIVE; NR4A1 PROTEIN, HUMAN; PHENOL DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL LINE; CANCER GROWTH; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG RECEPTOR BINDING; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REPORTER GENE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSACTIVATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; COLONIC NEOPLASMS; METABOLISM; TUMOR CELL LINE;

CELL LINE, TUMOR; COLONIC NEOPLASMS; HUMANS; INDOLES; MODELS, MOLECULAR; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; PHENOLS; RNA INTERFERENCE;

EID: 84907671500     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2014-1102     Document Type: Article

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