Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo

Molecular Medicine Reports

Volumn 11, Issue 6, 2015, Pages 4129-4134

  Wu, Cunzao ^a,b   Huang, Weiping ^a,b   Guo, Yong ^b   Xia, Peng ^b   Sun, Xianbin ^b   Pan, Xiaodong ^b   Hu, Weilie ^a,c  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

Apoptosis; Oxymatrine; Proliferation; Prostate cancer

Indexed keywords

ALANINE; ASPARTIC ACID; CREATINE PHOSPHATE; CREATININE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; GLYCEROPHOSPHORYLCHOLINE; LACTIC ACID; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; NEUROTRANSMITTER; PHOSPHORYLCHOLINE; TAURINE; ALKALOID; ANTINEOPLASTIC AGENT; OXYMATRINE; QUINOLIZINE DERIVATIVE;

ADULT; ANIMAL MODEL; ANIMAL TISSUE; APPARENT DIFFUSION COEFFICIENT; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN LEVEL; BRAIN TISSUE; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; EARLY DIAGNOSIS; IMAGE QUALITY; IN VIVO STUDY; MALE; METABOLITE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; RAT; ANIMAL; APOPTOSIS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; HUMAN; ISOLATION AND PURIFICATION; NUDE MOUSE; PATHOLOGY; PROSTATE; PROSTATIC NEOPLASMS; SOPHORA; TUMOR CELL LINE;

MUS MUSCULUS; SOPHORA FLAVESCENS;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MALE; MICE, NUDE; PROSTATE; PROSTATIC NEOPLASMS; QUINOLIZINES; SOPHORA;

EID: 84924652391     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3338     Document Type: Article

References (28)

1. Dunn MW and Kazer MW: Prostate cancer overview. Semin Oncol Nurs 27: 241-250, 2011.
2. Katahira K, Takahara T, Kwee TC, Oda S, Suzuki Y, Morishita S, Kitani K, Hamada Y, Kitaoka M and Yamashita Y: Ultra-high-b-value diffusion-weighted MR imaging for the detection of prostate cancer: evaluation in 201 cases with histopathological correlation. Eur Radiol 21: 188-196, 2011.
3. Gosselaar C, Roobol MJ, Roemeling S, van der Kwast TH and Schröder FH: Screening for prostate cancer at low PSA range: the impact of digital rectal examination on tumor incidence and tumor characteristics. Prostate 67: 154-161, 2007.
4. Shi GH, Ye DW, Yao XD, Zhang SL, Dai B, Zhang HL, Shen YJ, Zhu Y, Zhu YP, Xiao WJ and Ma CG: Involvement of microRNA-21 in mediating chemo-resistance to docetaxel in androgen-independent prostate cancer PC3 cells. Acta Pharmacol Sin 31: 867-873, 2010.
5. Liu YH, Li ML, Hsu MY, Pang YY, Chen IL, Chen CK, Tang SW, Lin HY and Lin JY: Effects of a Chinese herbal medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on renal cancer cell growth and metastasis. Evid Based Complement Alternat Med 2012: 935860, 2012.
6. Huang M, Hu YY, Dong XQ, Xu QP, Yu WH and Zhang ZY: The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain. J Ethnopharmacol 143: 228-235, 2012.
7. Chai NL, Fu Q, Shi H, Cai CH, Wan J, Xu SP and Wu BY: Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells. World J Gastroenterol 18: 4199-4206, 2012.
8. Hong-Li S, Lei L, Lei S, Dan Z, De-Li D, Guo-Fen Q, Yan L, Wen-Feng C and Bao-Feng Y: Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats. Phytother Res 22: 985-989, 2008.
9. Liu Y, Xu Y, Ji W, Li X, Sun B, Gao Q and Su C: Antitumor activities of matrine and oxymatrine: literature review. Tumour Biol 35: 5111-5119, 2014.
10. Song G, Luo Q, Qin J, Wang L, Shi Y and Sun C: Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells. Colloids Surf B Biointerfaces 48: 1-5, 2006.
11. Ling Q, Xu X, Wei X, Wang W, Zhou B, Wang B and Zheng S: Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. J Exp Clin Cancer Res 30: 66, 2011.
12. Chen H, Zhang J, Luo J, Lai F, Wang Z, Tong H, Lu D, Bu H, Zhang R and Lin S: Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-B-mediated VEGF signaling pathway. Oncol Rep 30: 589-595, 2013.
13. Zhang Y, Sun S, Chen J, Ren P, Hu Y, Cao Z, Sun H and Ding Y: Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway. Tumour Biol 35: 1619-1625, 2014.
14. Song MQ, Zhu JS, Chen JL, Wang L, Da W, Zhu L and Zhang WP: Synergistic effect of oxymatrine and angiogenesis inhibitor NM3 on modulating apoptosis in human gastric cancer cells. World J Gastroenterol 13: 1788-1793, 2007.
15. Zhang Y, Piao B, Zhang Y, Hua B, Hou W, Xu W, Qi X, Zhu X, Pei Y and Lin H: Oxymatrine diminishes the side population and inhibits the expression of catenin in MCF 7 breast cancer cells. Med Oncol 28 (Suppl 1): S99-S107, 2011.
16. Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJ and Cohen GM: Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ 16: 1030-1039, 2009.
17. Silva MT: Secondary necrosis: the natural outcome of the complete apoptotic program. FEBS Lett 584: 4491-4499, 2010.
18. Frew AJ, Johnstone RW and Bolden JE: Enhancing the apoptotic and therapeutic effects of HDAC inhibitors. Cancer Lett 280: 125-133, 2009.
19. Hou J, Wang D, Zhang R and Wang H: Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res 14: 5519-5530, 2008.
20. Vazquez A, Bond EE, Levine AJ and Bond GL: The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov 7: 979-987, 2008.
21. Hu W, Ge Y, Ojcius DM, Sun D, Dong H, Yang XF and Yan J: p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species. Cell Microbiol 15: 1642-1659, 2013.
22. Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, Le Marchand-Brustel Y, Giorgetti-Peraldi S, Cormont M, Bertolotto C, et al: Targeting cancer cell metabolism: the combination of metformin and 2deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res 70: 2465-2475, 2010.
23. Gomez-Lazaro M, Galindo MF, Concannon CG, Segura MF, Fernandez-Gomez FJ, Llecha N, Comella JX, Prehn JH and Jordan J: 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. J Neurochem 104: 1599-1612, 2008.
24. Ramaiah MJ, Pushpavalli SN, Lavanya A, Bhadra K, Haritha V, Patel N, Tamboli JR, Kamal A, Bhadra U and Pal-Bhadra M: Novel anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis. Bioorg Med Chem Lett 23: 5699-5706, 2013.
25. Deng Y and Wu X: Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria. Proc Natl Acad Sci USA 97: 12050-12055, 2000.
26. Gogada R, Prabhu V, Amadori M, Scott R, Hashmi S and Chandra D: Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)mediated Bax protein oligomerization on mitochondria to initiate cytochrome C release and caspase activation. J Biol Chem 286: 28749-28760, 2011.
27. Bishayee K, Chakraborty D, Ghosh S, Boujedaini N and Khuda-Bukhsh AR: Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction. Eur J Pharmacol 698: 110-121, 2013.
28. Liu Y, Yang Y, Ye YC, Shi QF, Chai K, Tashiro S, Onodera S and Ikejima T: Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells. J Pharmacol Sci 118: 423-432, 2012.