Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats

Phytotherapy Research

Volumn 22, Issue 7, 2008, Pages 985-989

  Hong Li, Sun ^a,b   Lei, Li ^a   Lei, Shang ^a   Dan, Zhao ^a   De Li, Dong ^a   Guo Fen, Qiao ^a   Yan, Liu ^a   Wen Feng, Chu ^a   Bao Feng, Yang ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Daqing Campus of Harbin Medical University ^*  (China)

Author keywords

Apoptosis; Bcl 2; Fas; Intracellular Ca 2+; Myocardial infarction; Oxymatrine

Indexed keywords

CALCIUM ION; FAS ANTIGEN; MALONALDEHYDE; OXYMATRINE; PROTEIN BCL 2;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL PROTECTION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MECHANISM; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIPID PEROXIDATION; MALE; NONHUMAN; RAT;

ALKALOIDS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; APOPTOSIS; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HEART VENTRICLES; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; PHYTOTHERAPY; QUINOLIZINES; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

RATTUS;

EID: 48749105482     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2452     Document Type: Article

References (10)

1. + currents densities in ventricular myocytes of guinea pigs by chronic oxidant stress. Acta Pharmacol Sin 25: 751-755.
2. Huang CY, Huang SY, Xie SR et al. 2001. Experimental studies on antiarrhythmic effects of oxymatrine. J Dalian Med Univ 23: 262-263.
3. Nagata S, Golstein P. 1995. The Fas death factor. Science 267: 1449-1456.
4. Reed JC, Miyashita T, Takayama S et al. 1996. Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 60: 23-32.
5. Rezvani M, Barrans JD, Dai KS et al. 2000. Apoptosis-related genes expressed in cardiovascular development and disease: an EST approach. Cardiovasc Res 45: 621-629.
6. Sun HL, Chu WF, Dong DL et al. 2006a. Choline-modulated arsenic trioxide-induced prolongation of cardiac repolarization in guinea pig. Basic Clin Pharmacol Toxicol 98: 381-388.
7. Sun J, Huang SH, Tan BK et al. 2005. Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction. Life Sci 76: 2849-2860.
8. Sun HL, Jiao JD, Pan ZW et al. 2006b. The cardioprotective effect and mechanism of lumbrokinase. Acta Pharm Sin 41: 247-251.
9. Wang B, Wang GJ, Xu J. 2000. Inhibitory effect of oxymatrine on vascular endothelial cell proliferation induced by tumor. J Pract Oncol 15: 297-300.
10. Xiang XX, Wang GJ, Cai X et al. 2002. Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis. Chin Med J 115: 593-596.