Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway

Tumor Biology

Volumn 35, Issue 2, 2014, Pages 1619-1625

  Zhang, Yong ^a   Sun, Siguo ^a   Chen, Jun ^a   Ren, Pengcheng ^a   Hu, Yunsheng ^a   Cao, Zhuo ^a   Sun, Honghui ^a   Ding, Yong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Mitochondria; Osteosarcoma; Oxymatrine; PI3K Akt; Sophora flavescens

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; BROXURIDINE; CASPASE 3; CASPASE 9; CYTOCHROME C; OXYMATRINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; DNA SYNTHESIS INHIBITION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ASSAY; EXPERIMENTAL NEOPLASM; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR VOLUME; UPREGULATION; WESTERN BLOTTING;

ALKALOIDS; ANIMALS; APOPTOSIS; CELL PROLIFERATION; DNA; ELAFIN; FEMALE; HUMANS; MICE; MITOCHONDRIA; ONCOGENE PROTEIN V-AKT; OSTEOSARCOMA; QUINOLIZINES; SIGNAL TRANSDUCTION; SOPHORA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898923003     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-1223-z     Document Type: Article

References (44)

1. Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer. 2009;115:1531-43.
2. Lee JA, Kim MS, Kim DH, Lim JS, Yoo JY, Koh JS, et al. Relative tumor burden predicts metastasis-free survival in pediatric osteosarcoma. Pediatr Blood Cancer. 2008;50:195-200.
3. Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G. Primary bone osteosarcoma in the pediatric age: state of the art. Cancer Treat Rev. 2006;32:423-36. (Pubitemid 44309249)
4. de Saint Aubain Somerhausen N, Fletcher CD. Soft-tissue sarcomas: an update. Eur J Surg Oncol. 1999;25:215-20. (Pubitemid 29182468)
5. Boos G, Stopper H. Genotoxicity of several clinically used topoisomerase II inhibitors. Toxicol Lett. 2000;116:7-16. (Pubitemid 30440762)
6. Marina N, Gebhardt M, Teot L, Gorlick R. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist. 2004;9:422-41. (Pubitemid 39014554)
7. Huang T, Gong WH, Li XC, Zou CP, Jiang GJ, Li XH, et al. Synergistic increase in the sensitivity of osteosarcoma cells to thermochemotherapy with combination of paclitaxel and etoposide. Mol Med Rep. 2012;6:1013-7.
8. Liu Y, Wang L, Wu Y, Lv C, Li X, Cao X, et al. Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. Toxicology. 2013;304:120-31.
9. Tian L, Yin D, Ren Y, Gong C, Chen A, Guo FJ. Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. Mol Med Rep. 2012;5:126-32.
10. Kerr JF. Shrinkage necrosis: a distinct mode of cellular death. J Pathol. 1971;105:13-20.
11. Yang R, Liu A, Ma X, Li L, Su D, Liu J. Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation. J Cardiovasc Pharmacol. 2008;51:396-401. (Pubitemid 351572239)
12. Carson DA, Ribeiro JM. Apoptosis and disease. Lancet. 1993;341: 1251-4. (Pubitemid 23146938)
13. Neto CC, Amoroso JW, Liberty AM. Anticancer activities of cranberry phytochemicals: an update. Mol Nutr Food Res. 2008;52:S18-27.
14. Kaur M, Agarwal R. Transcription factors: molecular targets for prostate cancer intervention by phytochemicals. Curr Cancer Drug Targets. 2007;7:355-67. (Pubitemid 46849240)
15. Broker LE, Kruyt FA, Giaccone G. Cell death independent of caspase: a review. Clin Cancer Res. 2005;11:3155-62. (Pubitemid 40627860)
16. Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011;144:926.
17. Adams JM, Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene. 2007;26:1324-37. (Pubitemid 46328466)
18. Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer. 2002;2:647-56. (Pubitemid 37328916)
19. Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer. 2002;2:277-88. (Pubitemid 37328781)
20. Su ZY, Tung YC, Hwang LS, Sheen LY. Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways. J Agric Food Chem. 2011;59:5109-16.
21. Kim D, Chung J. Akt: versatile mediator of cell survival and beyond. J Biochem Mol Biol. 2002;35:106-15. (Pubitemid 35216586)
22. Kurinna SM, Tsao CC, Nica AF, Jiffar T, Ruvolo PP. Ceramide promotes apoptosis in lung cancer-derived A549 cells by a mechanism involving c-Jun NH2-terminal kinase. Cancer Res. 2004;64:7852-6. (Pubitemid 39446918)
23. Zhang J, Kamdar O, Le W, Rosen GD, Upadhyay D. Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. Am J Respir Cell Mol Biol. 2009;40:135-46.
24. Wang B, Wang GJ, Xu J. Inhibitory effect of oxymatrine on vascular endothelial cell proliferation induced by tumor. J Pract Oncol. 2000;15:297-300.
25. Cao YG, Jing S, Li L, Gao JQ, Shen ZY, Liu Y, et al. Antiarrhythmic effects and ionic mechanisms of oxymatrine from sophora flavescens. Phytother Res. 2010;24:1844-9.
26. Cui X, Wang Y, Kokudo N, Fang D, Tang W. Traditional Chinese medicine and related active compounds against hepatitis b virus infection. Biosci Trends. 2010;4:39-47.
27. Deng ZY, Li J, Jin Y, Chen XL, Lu XW. Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with ccl4 induced hepatic fibrosis. Chin Med J (Engl). 2009;122:1449-54.
28. Fan H, Li L, Zhang X, Liu Y, Yang C, Yang Y, et al. Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia. Mediat Inflamm. 2009;2009: 704706.
29. Chen H, Zhang J, Luo J, Lai F, Wang Z, Tong H, et al. Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-κB-mediated VEGF signaling pathway. Oncol Rep. 2013;30:589-95.
30. Ling Q, Xu X, Wei X, Wang W, Zhou B, Wang B, et al. Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. J Exp Clin Cancer Res. 2011;30:66.
31. Ho JW, Ngan Hon PL, Chim WO. Effects of oxymatrine from Ku Shen on cancer cells. Anticancer Agents Med Chem. 2009;9:823-6.
32. Zou J, Ran ZH, Xu Q, Xiao SD. Experimental study of the killing effects of oxymatrine on human colon cancer cell line SW1116. Chin J Dig Dis. 2005;6:15-20. (Pubitemid 40467729)
33. Song MQ, Zhu JS, Chen JL, Wang L, Da W, Zhu L, et al. Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells. World J Gastroenterol. 2007;13:1788-93. (Pubitemid 46706010)
34. Xu Q, Jin XF, Ran ZH, Yang CH, Xiao SD. Chemopreventive effect of oxymatrine on N-methyl-N'-nitro-N-nitrosoguanidine induced gastrointestinal cancer: experiment with rats. Zhonghua Yi Xue Za Zhi. 2007;87:855-8. (Pubitemid 46851288)
35. Zhang Y, Piao BK, Zhang Y, Hua BJ, Hou W, Xu WR, et al. Oxymatrine diminishes the side population and inhibits the expression of β-catenin in MCF-7 breast cancer cells. Med Oncol. 2011;28:99-107.
36. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998;94:481-90. (Pubitemid 28391864)
37. Soeda J, Miyagawa S, Sano K, Masumoto J, Taniguchi S, Kawasaki S. Cytochrome c release into cytosol with subsequent caspase activation during warm ischemia in rat liver. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1115-23.
38. Allen RT, Hunter 3rd WJ, Agrawal DK. Morphological and biochemical characterization and analysis of apoptosis. J Pharmacol Toxicol Methods. 1997;37:215-28. (Pubitemid 27380389)
39. Qi F, Li A, Zhao L, Xu H, Inagaki Y, Wang D, et al. Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. J Ethnopharmacol. 2010;128:654-61.
40. Tian Z, Shen J, Moseman AP, Yang Q, Yang J, Xiao P, et al. Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells. Int J Cancer. 2008;122:31-8. (Pubitemid 350209975)
41. Stennicke HR, Salvesen GS. Properties of the caspases. Biochim Biophys Acta. 1998;1387:17-31. (Pubitemid 28529204)
42. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol. 1999;15:269-90. (Pubitemid 32250377)
43. Kirkin V, Joos S, Zörnig M. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta. 2004;1644:229-49. (Pubitemid 38281277)
44. Dan S, Yamori T. Repression of cyclin B1 expression after treatment with adriamycin, but not cisplatin in human lung cancer A549 cells. Biochem Biophys Res Commun. 2001;280:861-7. (Pubitemid 32924511)