Tuberculous meningitis: Advances in diagnosis and treatment

British Medical Bulletin

Volumn 113, Issue 1, 2015, Pages 117-131

  Torok M E ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

diagnosis; meningitis; treatment; Tuberculosis; tuberculous meningitis

Indexed keywords

ANTIINFLAMMATORY AGENT; TUBERCULOSTATIC AGENT; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN;

ADJUVANT THERAPY; ARTICLE; BACTERIUM CULTURE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL FEATURE; DISEASE ASSOCIATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LABORATORY DIAGNOSIS; MYCOBACTERIUM TUBERCULOSIS; PATHOGENESIS; PRIORITY JOURNAL; TUBERCULOUS MENINGITIS; COMBINATION DRUG THERAPY; DRUG EFFECTS; GENETICS; HOST PATHOGEN INTERACTION; MICROBIOLOGY; PHYSIOLOGY; PRACTICE GUIDELINE; PROCEDURES; TREATMENT OUTCOME; TUBERCULOSIS, MENINGEAL;

ANTITUBERCULAR AGENTS; DRUG THERAPY, COMBINATION; HOST-PATHOGEN INTERACTIONS; HUMANS; ISONIAZID; MYCOBACTERIUM TUBERCULOSIS; PRACTICE GUIDELINES AS TOPIC; PYRAZINAMIDE; RIFAMPIN; TREATMENT OUTCOME; TUBERCULOSIS, MENINGEAL;

EID: 84924611920     PISSN: 00071420     EISSN: 14718391     Source Type: Journal    
DOI: 10.1093/bmb/ldv003     Document Type: Article

References (115)

1. Hopewell PC, Jasmer RM. Overview of clinical tuberculosis. In: Cole KDEST, Murray DN, Jacobs WR (eds). Tuberculosis and the Tubercle Bacillus. Washington DC: ASM Press, 2005.
2. Farer LS, Lowell AM, Meador MP. Extrapulmonary tuberculosis in the United States. Am J Epidemiol 1979;109:205-17.
3. Davis LE, Rastogi KR, Lambert LC, et al. Tuberculous meningitis in the southwest United States: a community-based study. Neurology 1993;43:1775-8.
4. Kent SJ, Crowe SM, Yung A, et al. Tuberculous meningitis: a 30-year review. Clin Infect Dis 1993;17:987-94.
5. Verdon R, Chevret S, Laissy JP, et al. Tuberculous meningitis in adults: review of 48 cases. Clin Infect Dis 1996;22:982-8.
6. Kilpatrick ME, Girgis NI, Yassin MW, et al. Tuberculous meningitis-clinical and laboratory review of 100 patients. J Hyg (Lond) 1986;96:231-8.
7. Hosoglu S, Ayaz C, Geyik MF, et al. Tuberculous meningitis in adults: an eleven-year review. Int J Tuberc Lung Dis 1998;2:553-7.
8. Farinha NJ, Razali KA, Holzel H, et al. Tuberculosis of the central nervous system in children: a 20-year survey. J Infect 2000;41:61-8.
9. Thwaites GE, Tran TH. Tuberculous meningitis: many questions, too few answers. Lancet Neurol 2005;4: 160-70.
10. Thwaites GE, Nguyen DB, Nguyen HD, et al. Dexametha-sone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med 2004;351:1741-51.
11. Kocen RS, Parsons M. Neurological complications of tuberculosis: some unusual manifestations. Q J Med 1970;39:17-30.
12. Udani PM, Dastur DK. Tuberculous encephalopathy with and without meningitis. Clinical features and pathological correlations. J Neurol Sci 1970;10:541-61.
13. Udani PM, Parekh UC, Dastur DK. Neurological and related syndromes in CNS tuberculosis. Clinical features and pathogenesis. J Neurol Sci 1971;14:341-57.
14. Alarcon F, Duenas G, Cevallos N, et al. Movement disorders in 30 patients with tuberculous meningitis. Mov Disord 2000;15:561-9.
15. Dastur HM. A tuberculoma review with some personal experiences. II. Spinal cord and its coverings. Neurol India 1972;20:127-31.
16. Hernandez-Albujar S, Arribas JR, Royo A, et al. Tuberculous radiculomyelitis complicating tuberculous meningitis: case report and review. Clin Infect Dis 2000;30: 915-21.
17. Rapoport S, West CD, Brodsky WA. Salt losing conditions; the renal defect in tuberculous meningitis. J Lab Clin Med 1951;37:550-61.
18. Cotton MF, Donald PR, Schoeman JF, et al. Raised intracranial pressure, the syndrome of inappropriate antidiuretic hormone secretion, and arginine vasopres-sin in tuberculous meningitis. Childs Nerv Syst 1993;9:10-5; discussion 15-6.
19. Narotam PK, Kemp M, Buck R, et al. Hyponatremic natriuretic syndrome in tuberculous meningitis: the probable role of atrial natriuretic peptide. Neurosurgery 1994;34:982-8; discussion 988.
20. Dass R, Nagaraj R, Murlidharan J, et al. Hyponatrae-mia and hypovolemic shock with tuberculous meningitis. Indian J Pediatr 2003;70:995-7.
21. Cotton MF, Donald PR, Schoeman JF, et al. Plasma arginine vasopressin and the syndrome of inappropriate antidiuretic hormone secretion in tuberculous meningitis. Pediatr Infect Dis J 1991;10:837-42.
22. Sakarcan A, Bocchini J Jr. The role of fludrocortisone in a child with cerebral salt wasting. Pediatr Nephrol 1998;12:769-71.
23. Smith J, Godwin-Austen R. Hypersecretion of anti-diuretic hormone due to tuberculous meningitis. Postgrad Med J 1980;56:41-4.
24. Green PH. Tubercular meningitis. Lancet 1836;26: 232-5.
25. Koch R. Die aetiologie der tuberculosis. Berlin Klinische Wochenshrift 1882;19:232-5.
26. Rich AR, Mc Cordock HA. The pathogenesis of tuberculous meningitis. Bull John Hopkins Hosp 1933;52:5-37.
27. Dastur DK, Manghani DK, Udani PM. Pathology and pathogenetic mechanisms in neurotuberculosis. Radiol Clin North Am 1995;33:733-52.
28. Thwaites GE, Macmullen-Price J, Tran TH, et al. Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. Lancet Neurol 2007;6:230-6.
29. Laguna F, Adrados M, Ortega A, et al. Tuberculous meningitis with acellular cerebrospinal fluid in AIDS patients. AIDS 1992;6:1165-7.
30. Karstaedt AS, Valtchanova S, Barriere R, et al. Tuberculous meningitis in South African urban adults. QJM 1998;91:743-7.
31. Jeren T, Beus I. Characteristics of cerebrospinal fluid in tuberculous meningitis. Acta Cytol 1982;26:678-80.
32. Thwaites GE, Simmons CP, Than Ha Quyen N, et al. Pathophysiology and prognosis in vietnamese adults with tuberculous meningitis. J Infect Dis 2003; 188:1105-15.
33. Thwaites GE, Chau TT, Farrar JJ. Improving the bacteriological diagnosis of tuberculous meningitis. J Clin Microbiol 2004;42:378-9.
34. Dieli F, Sireci G, Di Sano C, et al. Predominance of Vgamma9/Vdelta2T lymphocytes in the cerebrospinal fluid of children with tuberculous meningitis: reversal after chemotherapy. Mol Med 1999;5:301-12.
35. Algood HM, Lin PL, Flynn JL. Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. Clin Infect Dis 2005;41(Suppl. 3):S189-93.
36. Sharief MK, Ciardi M, Thompson EJ. Blood-brain barrier damage in patients with bacterial meningitis: association with tumor necrosis factor-alpha but not interleukin-1 beta. J Infect Dis 1992;166:350-8.
37. Tsenova L, Bergtold A, Freedman VH, et al. Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system. Proc Natl Acad Sci USA 1999;96:5657-62.
38. Tsenova L, Sokol K, Freedman VH, et al. A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death. J Infect Dis 1998;177:1563-72.
39. Schoeman JF, Springer P, Ravenscroft A, et al. Adjunct-ive thalidomide therapy of childhood tuberculous meningitis: possible anti-inflammatory role. J Child Neurol 2000;15:497-503.
40. Schoeman JF, Springer P, van Rensburg AJ, et al. Adjun-ctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study. J Child Neurol 2004;19:250-7.
41. Simmons CP, Thwaites GE, Quyen NT, et al. Pretreat-ment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome. J Immunol 2006;176:2007-14.
42. Simmons CP, Thwaites GE, Quyen NT, et al. The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses. J Immunol 2005;175:579-90.
43. Tobin DM, Vary JC Jr, Ray JP, et al. The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell 2010;140:717-30.
44. Tobin DM, Roca FJ, Oh SF, et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 2012;148:434-46.
45. Hawn TR, Dunstan SJ, Thwaites GE, et al. A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. J Infect Dis 2006;194:1127-34.
46. Thuong NT, Hawn TR, Thwaites GE, et al. A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis. Genes Immun 2007;8:422-8.
47. Caws M, Thwaites G, Dunstan S, et al. The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLoS Pathog 2008;4:e1000034.
48. Steingart KR, Henry M, Ng V, et al. Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis 2006;6:570-81.
49. Anthony RM, Kolk AH, Kuijper S, et al. Light emitting diodes for auramine O fluorescence microscopic screening of Mycobacterium tuberculosis. Int J Tuberc Lung Dis 2006;10:1060-2.
50. Minion J, Pai M, Ramsay A, et al. Comparison of LED and conventional fluorescence microscopy for detection of acid fast bacilli in a low-incidence setting. PLoS ONE 2011;6:e22495.
51. World Health Organization. Fluorescent Light-Emitting Diode (LED) Microscopy for Diagnosis of Tuberculo-sis. Policy Statement WHO/HTM/TB/2011.8 Available at http://www.who.int/tb/publications/2011/led-microscopy- diagnosis-9789241501613/en/(28 January 2015, date last accessed).
52. Stewart SM. The bacteriological diagnosis of tuberculous meningitis. J Clin Pathol 1953;6:241-2.
53. Kennedy DH, Fallon RJ. Tuberculous meningitis. JAMA 1979;241:264-8.
54. Ho J, Marais BJ, Gilbert GL, et al. Diagnosing tuberculous meningitis-have we made any progress? Trop Med Int Health 2013;18:783-93.
55. Chen P, Shi M, Feng GD, et al. A highly efficient Ziehl-Neelsen stain: identifying de novo intracellular Myco-bacterium tuberculosis and improving detection of extracellular M. tuberculosis in cerebrospinal fluid. J Clin Microbiol 2012;50:1166-70.
56. Caviedes L, Lee TS, Gilman RH, et al. Rapid, efficient detection and drug susceptibility testing of Mycobacter-ium tuberculosis in sputum by microscopic observation of broth cultures. The Tuberculosis Working Group in Peru. J Clin Microbiol 2000;38:1203-8.
57. Minion J, Leung E, Menzies D, et al. Microscopic-observation drug susceptibility and thin layer agar assays for the detection of drug resistant tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2010;10:688-98.
58. Caws M, Dang TM, Torok E, et al. Evaluation of the MODS culture technique for the diagnosis of tuberculous meningitis. PLoS ONE 2007;2:e1173.
59. Dinnes J, Deeks J, Kunst H, et al. A systematic review of rapid diagnostic tests for the detection of tuberculosis infection. Health Technol Assess 2007;11:1-196.
60. Ling DI, Flores LL, Riley LW, et al. Commercial nucleic-acid amplification tests for diagnosis of pulmonary tuberculosis in respiratory specimens: meta-analysis and meta-regression. PLoS ONE 2008;3:e1536.
61. Duo L, Ying B, Song X, et al. Molecular profile of drug resistance in tuberculous meningitis from southwest china. Clin Infect Dis 2011;53:1067-73.
62. Drobniewski F, Nikolayevskyy V, Maxeiner H, et al. Rapid diagnostics of tuberculosis and drug resistance in the industrialized world: clinical and public health benefits and barriers to implementation. BMC Med 2013;11:190.
63. Vassall A, van Kampen S, Sohn H, et al. Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a cost-effectiveness analysis. PLoS Med 2011;8:e1001120.
64. Patel VB, Theron G, Lenders L, et al. Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study. PLoS Med 2013;10:e1001536.
65. Nhu NT, Heemskerk D, Thu do DA, et al. Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis. J Clin Microbiol 2014;52:226-33.
66. Patel VB, Connolly C, Singh R, et al. Comparison of Amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis. J Clin Microbiol 2014;52: 3777-80.
67. Sester M, Sotgiu G, Lange C, et al. Interferon-gamma release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. Eur Respir J 2011;37:100-11.
68. Diel R, Goletti D, Ferrara G, et al. Interferon-gamma release assays for the diagnosis of latent Mycobacter-ium tuberculosis infection: a systematic review and meta-analysis. Eur Respir J 2011;37:88-99.
69. Metcalfe JZ, Everett CK, Steingart KR, et al. Interferon-gamma release assays for active pulmonary tuberculosis diagnosis in adults in low-and middle-income countries: systematic review and meta-analysis. J Infect Dis 2011;204(Suppl. 4):S1120-9.
70. Achkar JM, Lawn SD, Moosa MY, et al. Adjunctive tests for diagnosis of tuberculosis: serology, ELISPOT for site-specific lymphocytes, urinary lipoarabinoman-nan, string test, and fine needle aspiration. J Infect Dis 2011;204(Suppl. 4):S1130-41.
71. Kim SH, Cho OH, Park SJ, et al. Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. Clin Infect Dis 2010;50:1349-58.
72. Patel VB, Singh R, Connolly C, et al. Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus-and tuberculosis-endemic population. Am J Respir Crit Care Med 2010;182:569-77.
73. Vidhate MR, Singh MK, Garg RK, et al. Diagnostic and prognostic value of Mycobacterium tuberculosis complex specific interferon gamma release assay in patients with tuberculous meningitis. J Infect 2011;62: 400-3.
74. Park KH, Cho OH, Lee EM, et al. T-cell-based assays on cerebrospinal fluid and PBMCs for rapid diagnosis of TB meningitis in non-HIV patients. Eur Respir J 2012;39:768-70.
75. Haldar S, Sankhyan N, Sharma N, et al. Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children. PLoS ONE 2012;7:e44630.
76. Shao Y, Xia P, Zhu T, et al. Sensitivity and specificity of immunocytochemical staining of mycobacterial antigens in the cytoplasm of cerebrospinal fluid macro-phages for diagnosing tuberculous meningitis. J Clin Microbiol 2011;49:3388-91.
77. Huy NT, Thao NT, Diep DT, et al. Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis. Crit Care 2010;14:R240.
78. Sakushima K, Hayashino Y, Kawaguchi T, et al. Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis. J Infect 2011;62:255-62.
79. Chen Z, Wang Y, Zeng A, et al. The clinical diagnostic significance of cerebrospinal fluid D-lactate for bacterial meningitis. Clin Chim Acta 2012;413:1512-5.
80. Majwala A, Burke R, Patterson W, et al. Handheld point-of-care cerebrospinal fluid lactate testing predicts bacterial meningitis in Uganda. Am J Trop Med Hyg 2013;88:127-31.
81. Mekitarian Filho E, Horita SM, Gilio AE, et al. Cerebro-spinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children. Int J Emerg Med 2014;7:14.
82. Tuon FF, Higashino HR, Lopes MI, et al. Adenosine dea-minase and tuberculous meningitis-a systematic review with meta-analysis. Scand J Infect Dis 2010;42:198-207.
83. Erdem H, Ozturk-Engin D, Elaldi N, et al. The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study. Clin Microbiol Infect 2014;20: O600-8.
84. Kataria J, Rukmangadachar LA, Hariprasad G, et al. Two dimensional difference gel electrophoresis analysis of cerebrospinal fluid in tuberculous meningitis patients. J Proteomics 2011;74:2194-203.
85. Bafica A, Scanga CA, Serhan C, et al. Host control of Mycobacterium tuberculosis is regulated by 5-lipoxy-genase-dependent lipoxin production. J Clin Invest 2005;115:1601-6.
86. Chen M, Divangahi M, Gan H, et al. Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. J Exp Med 2008;205:2791-801.
87. Herb F, Thye T, Niemann S, et al. ALOX5 variants associated with susceptibility to human pulmonary tuberculosis. Hum Mol Genet 2008;17:1052-60.
88. Streptomycin in Tuberculosis Trials Commitee, Medical Research Council. Streptomycin treatment of tuberculous meningitis. Lancet 1948; 251: 582-96.
89. Treatment of pulmonary tuberculosis with isoniazid; an interim report to the Medical Research Council by their Tuberculosis Chemotherapy Trials Committee. Br Med J 1952;2:735-46.
90. Nitti V. Results and tolerance of prolonged rifampicin treatment in recent and chronic forms of pulmonary tuberculosis. Respiration 1971;28(Suppl):57-69.
91. A controlled trial of six months chemotherapy in pulmonary tuberculosis. First Report: results during chemotherapy. British Thoracic Association. Br J Dis Chest 1981;75:141-53.
92. National Institute of Clinical Excellence. NICE Clinical Guideline CG33. Tuberculosis. Clinical Diagnosis and Management of Tuberculosis, and Measures for Its Prevention and Control. 2011. Available at http://www. nice.org.uk/guidance/cg33 (28 January 2015, date last accessed)
93. Donald PR. The chemotherapy of tuberculous meningitis in children and adults. Tuberculosis (Edinb) 2010; 90:375-92.
94. Thwaites GE, Lan NT, Dung NH, et al. Effect of antitu-berculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis. J Infect Dis 2005;192:79-88.
95. Vinnard C, Winston CA, Wileyto EP, et al. Isoniazid resistance and death in patients with tuberculous meningitis: retrospective cohort study. BMJ 2010;341: c4451.
96. Thwaites GE, Bhavnani SM, Chau TT, et al. Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis. Antimicrob Agents Chemother 2011;55:3244-53.
97. Ruslami R, Ganiem AR, Dian S, et al. Intensified regimen containing rifampicin and moxifloxacin for tuberculous meningitis: an open-label, randomised controlled phase 2 trial. Lancet Infect Dis 2013;13: 27-35.
98. Heemskerk D, Day J, Chau TT, et al. Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial. Trials 2011;12:25.
99. Torok ME, Chau TT, Mai PP, et al. Clinical and microbiological features of HIV-associated tuberculous meningitis in Vietnamese adults. PLoS ONE 2008;3: e1772.
100. Torok ME, Farrar JJ. When to start antiretroviral therapy in HIV-associated tuberculosis. N Engl J Med 2011;365:1538-40.
101. Abdool Karim Q, Abdool Karim SS, Baxter C, et al. The SAPIT trial provides essential evidence on risks and benefits of integrated and sequential treatment of HIV and tuberculosis. S Afr Med J 2010;100:808-9.
102. Blanc FX, Sok T, Laureillard D, et al. Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. N Engl J Med 2011;365: 1471-81.
103. Havlir DV, Kendall MA, Ive P, et al. ACTA GS. Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. N Engl J Med 2011;365:1482-91.
104. Abdool Karim SS, Naidoo K, Grobler A, et al. Integration of antiretroviral therapy with tuberculosis treatment. N Engl J Med 2011;365:1492-501.
105. Torok ME, Yen NT, Chau TT, et al. Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)-associated tuberculous meningitis. Clin Infect Dis 2011;52:1374-83.
106. Marais S, Meintjes G, Pepper DJ, et al. Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome. Clin Infect Dis 2013;56:450-60.
107. Shane SJ, Riley C. Tuberculous meningitis: combined therapy with cortisone and antimicrobial agents. N Engl J Med 1953;249:829-34.
108. Ashby M, Grant H. Tuberculous meningitis treated with cortisone. Lancet 1955;268:65-6.
109. O'Toole RD, Thornton GF, Mukherjee MK, et al. Dexamethasone in tuberculous meningitis. Relationship of cerebrospinal fluid effects to therapeutic efficacy. Ann Intern Med 1969;70:39-48.
110. Escobar JA, Belsey MA, Duenas A, et al. Mortality from tuberculous meningitis reduced by steroid therapy. Pediatrics 1975;56:1050-5.
111. Girgis NI, Farid Z, Kilpatrick ME, et al. Dexametha-sone adjunctive treatment for tuberculous meningitis. Pediatr Infect Dis J 1991;10:179-83.
112. Schoeman JF, Van Zyl LE, Laubscher JA, et al. Effect of corticosteroids on intracranial pressure, computed tomographic findings, and clinical outcome in young children with tuberculous meningitis. Pediatrics 1997; 99:226-31.
113. Torok ME, Nguyen DB, Tran TH, et al. Dexametha-sone and long-term outcome of tuberculous meningitis in Vietnamese adults and adolescents. PLoS ONE 2011;6:e27821.
114. Misra UK, Kalita J, Nair PP. Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial. J Neurol Sci 2010;293:12-7.
115. Schoeman JF, Janse van Rensburg A, Laubscher JA, et al. The role of aspirin in childhood tuberculous meningitis. J Child Neurol 2011;26:956-62.