Diagnostic Accuracy of Quantitative PCR (Xpert MTB/RIF) for Tuberculous Meningitis in a High Burden Setting: A Prospective Study

PLoS Medicine

Volumn 10, Issue 10, 2013, Pages

  Patel, Vinod B ^a   Theron, Grant ^b   Lenders, Laura ^b   Matinyena, Brian ^b   Connolly, Cathy ^c   Singh, Ravesh ^d   Coovadia, Yacoob ^a,e   Ndung'u, Thumbi ^d   Dheda, Keertan ^b,f  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

^f UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ADULT; ARTICLE; BACTERIAL LOAD; CD4 LYMPHOCYTE COUNT; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ASSESSMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; TUBERCULOUS MENINGITIS; XPERT MTB RIF;

ADULT; FEMALE; HUMANS; MALE; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; TUBERCULOSIS, MENINGEAL; YOUNG ADULT;

EID: 84886609298     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001536     Document Type: Article

References (41)

1. World Health Organization (2011) Global tuberculosis control. Geneva: World Health Organization.
2. Kwan CK, Ernst JD, (2011) HIV and tuberculosis: a deadly human syndemic. Clin Microbiol Rev 24: 351-376.
3. Braunwald E, Fauchi AS, Kasper DL, Hauser SL, Longo DL, et al. (2001) Harrisons's principles of internal medicine. New York: McGraw-Hill. 1028 p.
4. Ozbay B, Uzun K, (2002) Extrapulmonary tuberculosis in high prevalence of tuberculosis and low prevalence of HIV. Clin Chest Med 23: 351-354.
5. Garcia-Monco JC, (1999) Central nervous system tuberculosis. Neurol Clin 17: 737-759.
6. Karsteadt AS, Valtatchanova S, Barriere R, Crewe-Brown HH, (1998) Tuberculous meningitis in South African urban adults. QJM 91: 743-747.
7. Rock RB, Olin M, Baker CA, Molitor TW, Peterson PK, (2008) Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Microbiol Rev 21: 243-261.
8. Vinnard C, Macgregor RR, (2009) Tuberculous meningitis in HIV-infected individuals. Curr HIV/AIDS Rep 6: 139-145.
9. Pai M, Flores LL, Pai N, Hubbard A, Riley LW, et al. (2003) Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis. Lancet Infect Dis 3: 633-643.
10. Therese KL, Jayanthi U, Madhavan HN, (2005) Application of nested polymerase chain reaction (nPCR) using MPB 64 gene primers to detect Mycobacterium tuberculosis DNA in clinical specimens from extrapulmonary tuberculosis patients. Indian J Med Res 122: 165-170.
11. Boehme CC, Nabeta P, Hillemann D, Nicol MP, Shenai S, et al. (2010) Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 363: 1005-1015.
12. Bowles EC, Freyee B, van Ingen J, Mulder B, Boeree MJ, et al. (2011) Xpert MTB/RIF®, a novel automated polymerase chain reaction-based tool for the diagnosis of tuberculosis. Int J Tuberc Lung Dis 15: 988-989.
13. Theron G, Peter J, van Zyl-Smit R, Mishra H, Streicher E, et al. (2011) Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting. Am J Respir Crit Care Med 184: 132-140.
14. Lawn SD, Nicol MP, (2011) Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance. Future Microbiol 6: 1067-1082.
15. Simmons CP, Thwaites GE, Quyen NT, Torok E, Hoang DM, et al. (2006) Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome. J Immunol 176: 2007-2014.
16. Thwaites G, Chau TT, Mai NT, Drobniewski F, McAdam K, et al. (2000) Tuberculous meningitis. J Neurol Neurosurg Psychiatry 68: 289-299.
17. Thwaites G, Fisher M, Hemingway C, Scott G, Solomon T, et al. (2009) British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect 59: 167-187.
18. Schaaf HS, Moll AP, Dheda K, (2009) Multidrug- and extensively drug-resistant tuberculosis in Africa and South America: epidemiology, diagnosis and management in adults and children. Clin Chest Med 30: 667-683.
19. Pai M, Ling DI, (2008) Rapid diagnosis of extrapulmonary tuberculosis using nucleic acid amplification tests: what is the evidence? Future Microbiol 3: 1-4.
20. Raja S, Ching J, Xi L, Hughes SJ, Chang R, et al. (2005) Technology for automated, rapid, and quantitative PCR or reverse transcription-PCR clinical testing. Clin Chem 51: 882-890.
21. Cepheid (2009 April) Xpert MTB/RIF, 300-7810 Rev. A [package insert]. Sunnyvale (California): Cepheid.
22. Helb D, Jones M, Story E, Boehme C, Wallace E, et al. (2010) Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology. J Clin Microbiol 48: 229-237.
23. Patel VB, Singh R, Connolly C, Coovadia Y, Peer AK, et al. (2010) Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population. Am J Respir Crit Care Med 182: 569-577.
24. Bhigjee AI, Padayachee R, Paruk H, Hallwirth-Pillay KD, Marais S, et al. (2007) Diagnosis of tuberculous meningitis: clinical and laboratory parameters. Int J Infect Dis 11: 348-354.
25. Jarvis JN, Meintjes G, Williams A, Brown Y, Crede T, et al. (2010) Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases. BMC Infect Dis 10: 67.
26. Blakemore R, Nabeta P, Davidow AL, Vadwai V, Tahirli R, et al. (2011) A multisite assessment of the quantitative capabilities of the Xpert MTB/RIF assay. Am J Respir Crit Care Med 184: 1076-1084.
27. Friedrich SO, von Groote-Bidlingmaier F, Diacon AH, (2011) Xpert MTB/RIF assay for the diagnosis of pleural tuberculosis. J Clin Microbiol 49: 4341-4342.
28. Chang K, Lu W, Wang J, Zhang K, Jia S, et al. (2012) Rapid and effective diagnosis of tuberculosis and rifampicin resistance with Xpert MTB/RIF assay: a meta-analysis. J Infect 64: 580-588.
29. Hillemann D, Rusch-Gerdes S, Boehme C, Richter E, (2011) Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpert MTB/RIF system. J Clin Microbiol 49: 1202-1205.
30. Ioannidis P, Papaventsis D, Karabela S, Nikolaou S, Panagi M, et al. (2011) Cepheid GeneXpert MTB/RIF Assay for Mycobacterium tuberculosis detection and rifampin resistance identification in patients with high clinical suspicion of TB and smear negative microscopy. J Clin Microbiol 49: 3068-3070.
31. Vadwai V, Boehme C, Nabeta P, Shetty A, Alland D, et al. (2011) Xpert MTB/RIF: a new pillar in diagnosis of extrapulmonary tuberculosis? J Clin Microbiol 49: 2540-2545.
32. Causse M, Ruiz P, Gutierrez-Aroca JB, Casal M, (2011) Comparison of two molecular methods for rapid diagnosis of extrapulmonary tuberculosis. J Clin Microbiol 49: 3065-3067.
33. Eing BR, Becker A, Sohns A, Ringelmann R, (1998) Comparison of Roche Cobas Amplicor Mycobacterium tuberculosis assay with in-house PCR and culture for detection of M. tuberculosis. J Clin Microbiol 36: 2023-2029.
34. Jonsson B, Ridell M, (2003) The Cobas Amplicor MTB test for detection of Mycobacterium tuberculosis complex from respiratory and non-respiratory clinical specimens. Scand J Infect Dis 35: 372-377.
35. Thwaites GE, Chau TT, Stepniewska K, Phu NH, Chuong LV, et al. (2002) Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet 360: 1287-1292.
36. Thwaites GE, Chau TT, Farrar JJ, (2004) Improving the bacteriological diagnosis of tuberculous meningitis. J Clin Microbiol 42: 378-379.
37. Garg RK, (1999) Tuberculosis of the central nervous system. Postgrad Med J 75: 133-140.
38. van Zyl-Smit RN, Binder A, Meldau R, Mishra H, Semple PL, et al. (2011) Comparison of quantitative techniques including Xpert MTB/RIF to evaluate mycobacterial burden. PLoS ONE 6: e28815 doi:10.1371/journal.pone.0028815.
39. Theron G, Peter J, Dheda K, (2012) Characteristics of Xpert MTB/RIF-negative patients with pulmonary tuberculosis. Clin Infect Dis 55: 472-473.
40. Ratnamohan VM, Cunningham AL, Rawlinson WD, (1998) Removal of inhibitors of CSF-PCR to improve diagnosis of herpesviral encephalitis. J Virol Methods 72: 59-65.
41. Welinder-Olsson C, Dotevall L, Hogevik H, Jungnelius R, Trollfors B, et al. (2007) Comparison of broad-range bacterial PCR and culture of cerebrospinal fluid for diagnosis of community-acquired bacterial meningitis. Clin Microbiol Infect 13: 879-886.