Evaluation of genexpert MTB/RIF for diagnosis of tuberculous meningitis

Journal of Clinical Microbiology

Volumn 52, Issue 1, 2014, Pages 226-233

  Nhu, Nguyen Thi Quynh ^a   Heemskerk, Dorothee ^a   Thu, Do Dang Anh ^a   Chau, Tran Thi Hong ^b   Mai, Nguyen Thi Hoang ^b   Nghia, Ho Dang Trung ^b   Loc, Pham Phu ^b   Ha, Dang Thi Minh ^a,c   Merson, Laura ^a   Van Thinh, Tran Thi ^a   Day, Jeremy ^a   Van Vinh Chau, Nguyen ^b   Wolbers, Marcel ^a   Farrar, Jeremy ^a   Caws, Maxine ^a  

^a OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^c Pham Ngoc Thach Hospital   (Viet Nam)

Author keywords

[No Author keywords available]

Indexed keywords

RIFAMPICIN;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL LOAD; BACTERIUM CULTURE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; CULTURE TECHNIQUE; DIAGNOSTIC TEST ACCURACY STUDY; FALSE POSITIVE RESULT; HUMAN; MAJOR CLINICAL STUDY; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIAL GROWTH INDICATOR TUBE CULTURE; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS TEST KIT; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; TUBERCULOUS MENINGITIS; VIET NAM; ZIEHL NEELSEN SMEAR;

ADULT; AGED; AGED, 80 AND OVER; ANTITUBERCULAR AGENTS; CEREBROSPINAL FLUID; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MOLECULAR DIAGNOSTIC TECHNIQUES; MYCOBACTERIUM TUBERCULOSIS; RIFAMPIN; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS, MENINGEAL; VIETNAM; YOUNG ADULT;

EID: 84891550979     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01834-13     Document Type: Article

References (42)

1. Brancusi F, Farrar J, Heemskerk D. 2012. Tuberculous meningitis in adults: A review of a decade of developments focusing on prognostic factors for outcome. Future Microbiol. 7:1101-1116. http://dx.doi.org/10 .2217/fmb.12.86.
2. Thwaites GE. 2013. Advances in the diagnosis and treatment of tuberculous meningitis. Curr. Opin. Neurol. 26:295-300. http://dx.doi.org/10.1097/WCO. 0b013e3283602814.
3. Marais S, Pepper DJ, Marais BJ, Torok ME. 2010. HIV-associated tuberculous meningitis-diagnostic and therapeutic challenges. Tuberculosis (Edinb.) 90:367-374. http://dx.doi.org/10.1016/j.tube.2010.08 .006.
4. Hosoglu S, Geyik MF, Balik I, Aygen B, Erol S, Aygencel TG, Mert A, Saltoglu N, Dokmetas I, Felek S, Sunbul M, Irmak H, Aydin K, Kokoglu OF, Ucmak H, Altindis M, Loeb M. 2002. Predictors of outcome in patients with tuberculous meningitis. Int. J. Tuberc. Lung Dis. 6:64-70.
5. Hsu PC, Yang CC, Ye JJ, Huang PY, Chiang PC, Lee MH. 2010. Prognostic factors of tuberculous meningitis in adults: A 6-year retrospective study at a tertiary hospital in northern Taiwan. J. Microbiol. Immunol. Infect. 43:111-118. http://dx.doi.org/10.1016/S1684-1182(10)60018-7.
6. Marais S, Pepper DJ, Schutz C, Wilkinson RJ, Meintjes G. 2011. Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting. PLoS One 6:e20077. http://dx.doi.org/10.1371/journal .pone.0020077.
7. Misra UK, Kalita J, Roy AK, Mandal SK, Srivastava M. 2000. Role of clinical, radiological, and neurophysiological changes in predicting the outcome of tuberculous meningitis: A multivariable analysis. J. Neurol. Neurosurg. Psychiatry 68:300-303. http://dx.doi.org/10.1136/jnnp.68.3 .300.
8. Sheu JJ, Yuan RY, Yang CC. 2009. Predictors for outcome and treatment delay in patients with tuberculous meningitis. Am. J. Med. Sci. 338:134-139. http://dx.doi.org/10.1097/MAJ.0b013e3181a590f1.
9. Jongeling AC, Pisapia D. 2013. Pearls and oy-sters: Tuberculous meningitis. Not a diagnosis of exclusion. Neurology 80:e36-e39. http://dx.doi.org/10.1212/WNL.0b013e31827f0832.
10. Garg RK. 1999. Tuberculosis of the central nervous system. Postgrad. Med. J. 75:133-140.
11. Thwaites GE, Chau TT, Farrar JJ. 2004. Improving the bacteriological diagnosis of tuberculous meningitis. J. Clin. Microbiol. 42:378-379. http://dx.doi.org/10.1128/JCM.42.1.378-379.2004.
12. Cambanis A, Ramsay A, Wirkom V, Tata E, Cuevas LE. 2007. Investing time in microscopy: An opportunity to optimise smear-based case detection of tuberculosis. Int. J. Tuberc. Lung Dis. 11:40-45.
13. Hawken MP, Muhindi DW, Chakaya JM, Bhatt SM, Ng'ang'a LW, Porter JD. 2001. Under-diagnosis of smear-positive pulmonary tuberculosis in Nairobi, Kenya. Int. J. Tuberc. Lung Dis. 5:360-363.
14. Mundy CJ, Harries AD, Banerjee A, Salaniponi FM, Gilks CF, Squire SB. 2002. Quality assessment of sputum transportation, smear preparation and AFB microscopy in a rural district in Malawi. Int. J. Tuberc. Lung Dis. 6:47-54.
15. Caws M, Dang TM, Torok E, Campbell J, Do DA, Tran TH, Nguyen VC, Nguyen TC, Farrar J. 2007. Evaluation of the MODS culture technique for the diagnosis of tuberculous meningitis. PLoS One 2:e1173. http://dx.doi.org/10.1371/journal. pone.0001173.
16. Ho J, Marais BJ, Gilbert GL, Ralph AP. 2013. Diagnosing tuberculous meningitis-have we made any progress? Trop. Med. Int. Health 18:783-793. http://dx.doi.org/10.1111/tmi.12099.
17. Tuon FF, Higashino HR, Lopes MI, Litvoc MN, Atomiya AN, Antonangelo L, Leite OM. 2010. Adenosine deaminase and tuberculous meningitis-A systematic review with meta-analysis. Scand. J. Infect. Dis. 42: 198-207. http://dx.doi.org/10.3109/00365540903428158.
18. Pai M, Flores LL, Pai N, Hubbard A, Riley LW, Colford JM, Jr. 2003. Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: A systematic review and meta-analysis. Lancet Infect. Dis. 3:633-643. http://dx.doi.org/10.1016/S1473-3099(03)00772-2.
19. Lawn SD, Nicol MP. 2011. Xpert(R) MTB/RIF assay: Development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance. Future Microbiol. 6:1067-1082. http://dx.doi.org/10.2217/ fmb.11.84.
20. World Health Organization. 2011. Automated real time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system. Policy statement. WHO/HTM/TB/2011.4. World Health Organization, Geneva, Switzerland.
21. Boehme CC, Nabeta P, Hillemann D, Nicol MP, Shenai S, Krapp F, Allen J, Tahirli R, Blakemore R, Rustomjee R, Milovic A, Jones M, O'Brien SM, Persing DH, Ruesch-Gerdes S, Gotuzzo E, Rodrigues C, Alland D, Perkins MD. 2010. Rapid molecular detection of tuberculosis and rifampin resistance. N. Engl. J. Med. 363:1005-1015. http://dx.doi.org/10.1056/NEJMoa0907847.
22. Lawn SD, Brooks SV, Kranzer K, Nicol MP, Whitelaw A, Vogt M, Bekker LG, Wood R. 2011. Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: A prospective study. PLoS Med. 8:e1001067. http://dx.doi.org/10.1371/journal.pmed. 1001067.
23. Scott LE, McCarthy K, Gous N, Nduna M, Van Rie A, Sanne I, Venter WF, Duse A, Stevens W. 2011. Comparison of Xpert MTB/RIF with other nucleic acid technologies for diagnosing pulmonary tuberculosis in a high HIV prevalence setting: A prospective study. PLoS Med. 8:e1001061. http://dx.doi.org/10.1371/ journal.pmed.1001061.
24. Theron G, Peter J, van Zyl-Smit R, Mishra H, Streicher E, Murray S, Dawson R, Whitelaw A, Hoelscher M, Sharma S, Pai M, Warren R, Dheda K. 2011. Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting. Am. J. Respir. Crit. Care Med. 184:132-140. http://dx.doi.org/10.1164/rccm.201101-0056OC.
25. Steingart KR, Sohn H, Schiller I, Kloda LA, Boehme CC, Pai M, Dendukuri N. 2013. Xpert(R) MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst. Rev. 1:CD009593. http://dx.doi.org/10.1002/14651858.CD009593.pub2.
26. Lawn SD, Zumla AI. 2012. Diagnosis of extrapulmonary tuberculosis using the Xpert((R)) MTB/RIF assay. Expert Rev. Anti Infect. Ther. 10: 631-635. http://dx.doi.org/10.1586/eri.12.43.
27. Tortoli E, Russo C, Piersimoni C, Mazzola E, Dal MP, Pascarella M, Borroni E, Mondo A, Piana F, Scarparo C, Coltella L, Lombardi G, Cirillo DM. 2012. Clinical validation of Xpert MTB/RIF for the diagnosis of extrapulmonary tuberculosis. Eur. Respir. J. 40:442-447. http://dx.doi.org/10.1183/09031936. 00176311.
28. Hillemann D, Rusch-Gerdes S, Boehme C, Richter E. 2011. Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpert MTB/RIF system. J. Clin. Microbiol. 49:1202-1205. http://dx.doi.org/10.1128/JCM.02268- 10.
29. Moure R, Martin R, Alcaide F. 2012. Effectiveness of an integrated real-time PCR method for detection of the Mycobacterium tuberculosis complex in smear-negative extrapulmonary samples in an area of low tuberculosis prevalence. J. Clin. Microbiol. 50:513-515. http://dx.doi.org/10.1128/JCM.06467-11.
30. Vadwai V, Boehme C, Nabeta P, Shetty A, Alland D, Rodrigues C. 2011. Xpert MTB/RIF: A new pillar in diagnosis of extrapulmonary tuberculosis? J. Clin. Microbiol. 49:2540-2545. http://dx.doi.org/10.1128/JCM.02319-10.
31. Thwaites GE, Nguyen DB, Nguyen HD, Hoang TQ, Do TT, Nguyen TC, Nguyen QH, Nguyen TT, Nguyen NH, Nguyen TN, Nguyen NL, Nguyen HD, Vu NT, Cao HH, Tran TH, Pham PM, Nguyen TD, Stepniewska K, White NJ, Tran TH, Farrar JJ. 2004. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N. Engl. J. Med. 351:1741-1751. http://dx.doi.org/10.1056/NEJMoa040573.
32. Heemskerk D, Day J, Chau TT, Dung NH, Yen NT, Bang ND, Merson L, Olliaro P, Pouplin T, Caws M, Wolbers M, Farrar J. 2011. Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): Protocol for a randomized controlled trial. Trials 12:25. http://dx.doi.org/10.1186/1745-6215-12-25.
33. Becton Dickinson. 2010. Bactec MGIT SIRE drug kit package insert. Becton Dickinson, Sparks, MD. http://www.bd.com/ds/technicalCenter/inserts/ PP118JAA(201006).pdf.
34. World Health Organization. 2008. Molecular line probe assays for rapid screening of patients at risk of multidrug-resistant tuberculosis (MDR TB). World Health Organization, Geneva, Switzerland. http://www.who .int/tb/features-archive/policy-statement.pdf.
35. Honore-Bouakline S, Vincensini JP, Giacuzzo V, Lagrange PH, Herrmann JL. 2003. Rapid diagnosis of extrapulmonary tuberculosis by PCR: Impact of sample preparation and DNA extraction. J. Clin. Microbiol. 41:2323-2329. http://dx.doi.org/10.1128/JCM.41.6.2323-2329.2003.
36. HAIN Lifesciences. 2010. Genotype MTBDRplus package insert. Hain Lifesciences, Nehren, Germany.
37. Marais S, Thwaites G, Schoeman JF, Torok ME, Misra UK, Prasad K, Donald PR, Wilkinson RJ, Marais BJ. 2010. Tuberculous meningitis: A uniform case definition for use in clinical research. Lancet Infect. Dis. 10:803-812. http://dx.doi.org/10.1016/S1473-3099(10)70138-9.
38. Kennedy DH, Fallon RJ. 1979. Tuberculous meningitis. JAMA 241:264-268.
39. Thwaites GE, Lan NT, Dung NH, Quy HT, Oanh DT, Thoa NT, Hien NQ, Thuc NT, Hai NN, Bang ND, Lan NN, Duc NH, Tuan VN, Hiep CH, Chau TT, Mai PP, Dung NT, Stepniewska K, White NJ, Hien TT, Farrar JJ. 2005. Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis. J. Infect. Dis. 192:79-88. http://dx.doi.org/10.1086/430616.
40. Van Rie A, Mellet K, John MA, Scott L, Page-Shipp L, Dansey H, Victor T, Warren R. 2012. False-positive rifampicin resistance on Xpert(R) MTB/RIF: Case report and clinical implications. Int. J. Tuberc. Lung Dis. 16:206-208. http://dx.doi.org/10.5588/ijtld.11.0395.
41. Zhang Y, Yew WW. 2009. Mechanisms of drug resistance in Mycobacterium tuberculosis. Int. J. Tuberc. Lung Dis. 13:1320-1330.
42. Dinnes J, Deeks J, Kunst H, Gibson A, Cummins E, Waugh N, Drobniewski F, Lalvani A. 2007. A systematic review of rapid diagnostic tests for the detection of tuberculosis infection. Health Technol. Assess. 11:1-196. http://dx.doi.org/10.3310/hta11030.