Handheld point-of-care cerebrospinal fluid lactate testing predicts bacterial meningitis in Uganda

American Journal of Tropical Medicine and Hygiene

Volumn 88, Issue 1, 2013, Pages 127-131

  Majwala, Albert ^a   Burke, Rebecca ^b   Patterson, William ^c   Pinkerton, Relana ^c   Muzoora, Conrad ^a   Wilson, L Anthony ^a   Moore, Christopher C ^c  

^a MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Uganda)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

ADULT; ARTICLE; BACTERIAL MENINGITIS; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; FEMALE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE; POINT OF CARE LACTATE MONITOR; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; UGANDA;

HUMANS; LACTIC ACID; MENINGITIS, BACTERIAL; POINT-OF-CARE SYSTEMS; UGANDA;

BACTERIA (MICROORGANISMS);

EID: 84872334999     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2012.12-0447     Document Type: Article

References (13)

1. Ziai WC, Lewin JJ III, 2006. Advances in the management of central nervous system infections in the ICU. Crit Care Clin 22: 661-694. (Pubitemid 46110958)
2. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M, 2004. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 351: 1849-1859.
3. Petti CA, Polage CR, Quinn TC, Ronald AR, Sande MA, 2006. Laboratory medicine in Africa: a barrier to effective health care. Clin Infect Dis 42: 377-382. (Pubitemid 43122314)
4. Ross D, Rosegay H, Pons V, 1988. Differentiation of aseptic and bacterial meningitis in postoperative neurosurgical patients. J Neurosurg 69: 669- 674.
5. Guerra-Romero L, Tauber MG, Fournier MA, Tureen JH, 1992. Lactate and glucose concentrations in brain interstitial fluid, cerebrospinal fluid, and serum during experimental pneumococcal meningitis. J Infect Dis 166: 546-550.
6. Leib SL, Boscacci R, Gratzl O, Zimmerli W, 1999. Predictive value of cerebrospinal fluid (CSF) lactate level versus CSF/ blood glucose ratio for the diagnosis of bacterial meningitis following neurosurgery. Clin Infect Dis 29: 69-74. (Pubitemid 29336804)
7. Huy NT, Thao NT, Diep DT, Kikuchi M, Zamora J, Hirayama K, 2010. Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and metaanalysis. Crit Care 14: R240.
8. Muhumuza J, Asiimwe BB, Kayes S, Mugyenyi R, Whalen C, Mugerwa RD, Boom H, Eisenach KD, Joloba ML, 2006. Introduction of an in-house PCR for routine identification of M. tuberculosis in a low-income country. Int J Tuberc Lung Dis 10: 1262-1267. (Pubitemid 44713481)
9. Scarborough M, Thwaites GE, 2008. The diagnosis and management of acute bacterial meningitis in resource-poor settings. Lancet Neurol 7: 637-648.
10. Bailey EM, Domenico P, Cunha BA, 1990. Bacterial or viral meningitis? Measuring lactate in CSF can help you know quickly. Postgrad Med 88: 217-219, 223.
11. Cameron PD, Boyce JM, Ansari BM, 1993. Cerebrospinal fluid lactate inmeningitis andmeningococcaemia. J Infect 26: 245-252. (Pubitemid 23177543)
12. Genton B, Berger JP, 1990. Cerebrospinal fluid lactate in 78 cases of adult meningitis. Intensive Care Med 16: 196-200. (Pubitemid 20226775)
13. Trachtenberg JD, Kambugu AD, McKellar M, Semitala F, Mayanja-Kizza H, Samore MH, Ronald A, Sande MA, 2007. The medical management of central nervous system infections in Uganda and the potential impact of an algorithm-based approach to improve outcomes. Int J Infect Dis 11: 524-530. (Pubitemid 47626046)