Colorectal adenoma to carcinoma progression is accompanied by changes in gene expression associated with ageing, chromosomal instability, and fatty acid metabolism

Cellular Oncology

Volumn 35, Issue 1, 2012, Pages 53-63

  Carvalho, Beatriz ^a   Sillars Hardebol, Anke H ^a   Postma, Cindy ^a   Mongera, Sandra ^a   Droste, Jochim Terhaar Sive ^a   Obulkasim, Askar ^a   Van De Wiel, Mark ^a   Van Criekinge, Wim ^b   Ylstra, Bauke ^a   Fijneman, Remond J A ^a   Meijer, Gerrit A ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Ageing; Chromosomal instability; Colorectal cancer; Fatty acid metabolism; Gene expression; Progression

Indexed keywords

MESSENGER RNA; TUMOR MARKER; FATTY ACID;

ACCURACY; ADULT; AGED; AGING; ARTICLE; CANCER GROWTH; CANCER RISK; CHROMOSOMAL INSTABILITY; CHROMOSOME 20Q; CHROMOSOME 22; CHROMOSOME 4Q; CHROMOSOME LOSS; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; DOWN REGULATION; FATTY ACID METABOLISM; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPREGULATION; VALIDATION PROCESS; ADENOMA; COLORECTAL TUMOR; DISEASE COURSE; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETIC DATABASE; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; REPRODUCIBILITY; TUMOR GENE;

ADENOMA; AGED; AGED, 80 AND OVER; AGING; CHROMOSOMAL INSTABILITY; COLORECTAL NEOPLASMS; DATABASES, GENETIC; DISEASE PROGRESSION; DOWN-REGULATION; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS; UP-REGULATION;

EID: 84866159990     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-011-0065-1     Document Type: Article

References (78)

1. J. Ferlay, P. Autier, M. Boniol, M. Heanue, M. Colombet, P. Boyle, Estimates of the cancer incidence and mortality in Europe in 2006. Ann. Oncol. 18, 581-592 (2007) (Pubitemid 46359643)
2. T. Muto, H.J. Bussey, B.C. Morson, The evolution of cancer of the colon and rectum. Cancer 36, 2251-2270 (1975)
3. H. Shinya, W.I. Wolff, Morphology, anatomic distribution and cancer potential of colonic polyps. Ann. Surg. 190, 679-683 (1979)
4. M. Hermsen, C. Postma, J. Baak, M.Weiss, A. Rapallo, A. Sciutto, G. Roemen, J.W. Arends, R.Williams,W. Giaretti, A. De Goeij, G. Meijer, Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology 123, 1109-1119 (2002)
5. B. Carvalho, C. Postma, S. Mongera, E. Hopmans, S. Diskin, M.A. van de Wiel, C.W. van, O. Thas, A. Matthai, M.A. Cuesta, J.S. Terhaar Sive Droste, M. Craanen, E. Schrock, B. Ylstra, G.A. Meijer, Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression. Gut 58, 79-89 (2009)
6. E.R. Fearon, B. Vogelstein, A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990)
7. L.D. Wood, D.W. Parsons, S. Jones, J. Lin, T. Sjoblom, R.J. Leary, D. Shen, S.M. Boca, T. Barber, J. Ptak, N. Silliman, S. Szabo, Z. Dezso, V. Ustyanksky, T. Nikolskaya, Y. Nikolsky, R. Karchin, P. A. Wilson, J.S. Kaminker, Z. Zhang, R. Croshaw, J. Willis, D. Dawson, M. Shipitsin, J.K. Willson, S. Sukumar, K. Polyak, B.H. Park, C.L. Pethiyagoda, P.V. Pant, D.G. Ballinger, A.B. Sparks, J. Hartigan, D.R. Smith, E. Suh, N. Papadopoulos, P. Buckhaults, S. D. Markowitz, G. Parmigiani, K.W. Kinzler, V.E. Velculescu, B. Vogelstein, The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113 (2007) (Pubitemid 350134889)
8. R.J. Leary, J.C. Lin, J. Cummins, S. Boca, L.D. Wood, D.W. Parsons, S. Jones, T. Sjoblom, B.H. Park, R. Parsons, J. Willis, D. Dawson, J.K.Willson, T.Nikolskaya,Y. Nikolsky, L. Kopelovich, N. Papadopoulos, L.A. Pennacchio, T.L. Wang, S.D. Markowitz, G. Parmigiani, K.W. Kinzler, B. Vogelstein, V.E. Velculescu, Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc. Natl. Acad. Sci. U. S. A. 105, 16224-16229 (2008)
9. R.P. Brosens, J.C. Haan, B. Carvalho, F. Rustenburg, H. Grabsch, P. Quirke, A.F. Engel, M.A. Cuesta, N. Maughan, M. Flens, G.A. Meijer, B. Ylstra, Candidate driver genes in focal chromosomal aberrations of stage II colon cancer. J. Pathol. 221, 411-424 (2010)
10. T.A. Chan, S. Glockner, J.M. Yi,W. Chen, N.L. Van, L. Cope, J.G. Herman, V. Velculescu, K.E. Schuebel, N. Ahuja, S.B. Baylin, Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. PLoS. Med. 5, e114 (2008)
11. J.R. Bischoff, L. Anderson, Y. Zhu, K. Mossie, L. Ng, B. Souza, B. Schryver, P. Flanagan, F. Clairvoyant, C. Ginther, C.S. Chan, M. Novotny, D.J. Slamon, G.D. Plowman, A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052-3065 (1998) (Pubitemid 28254378)
12. A.K. Lam, K. Ong, Y.H. Ho, Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity. Hum. Pathol. 39, 599-604 (2008)
13. T. Macarulla, F.J. Ramos, J. Tabernero, Aurora kinase family: a new target for anticancer drug. Recent Pat. Anticancer Drug Discov. 3, 114-122 (2008)
14. O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, M.E. Nita, T. Takagi, Y. Nakamura, T. Tsunoda, Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia. Cancer Res. 61, 3544-3549 (2001) (Pubitemid 32694957)
15. T.T. Zou, F.M. Selaru, Y. Xu, V. Shustova, J. Yin, Y. Mori, D. Shibata, F. Sato, S. Wang, A. Olaru, E. Deacu, T.C. Liu, J.M. Abraham, S.J. Meltzer, Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. Oncogene 21, 4855-4862 (2002) (Pubitemid 34879462)
16. K. Birkenkamp-Demtroder, L.L. Christensen, S.H. Olesen, C.M. Frederiksen, P. Laiho, L.A. Aaltonen, S. Laurberg, F.B. Sorensen, R. Hagemann, T.F. ORntoft, Gene expression in colorectal cancer. Cancer Res. 62, 4352-4363 (2002) (Pubitemid 34827293)
17. F. Bertucci, S. Salas, S. Eysteries, V. Nasser, P. Finetti, C. Ginestier, E. Charafe-Jauffret, B. Loriod, L. Bachelart, J.Montfort, G. Victorero, F. Viret, V. Ollendorff, V. Fert, M. Giovaninni, J.R. Delpero, C. Nguyen, P. Viens, G. Monges, D. Birnbaum, R. Houlgatte, Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters. Oncogene 23, 1377-1391 (2004) (Pubitemid 38406833)
18. M. Bianchini, E. Levy, C. Zucchini, V. Pinski, C. Macagno, S.P. De, L. Valvassori, P. Carinci, J. Mordoh, Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa. Int. J. Oncol. 29, 83-94 (2006)
19. C.P. Giacomini, S.Y. Leung, X. Chen, S.T. Yuen, Y.H. Kim, E. Bair, J.R. Pollack, A gene expression signature of genetic instability in colon cancer. Cancer Res. 65, 9200-9205 (2005) (Pubitemid 41507985)
20. M. Kruhoffer, J.L. Jensen, P. Laiho, L. Dyrskjot, R. Salovaara, D. Arango, K. Birkenkamp-Demtroder, F.B. Sorensen, L.L. Christensen, L. Buhl, J.P.Mecklin, H. Jarvinen, T. Thykjaer, F.P.Wikman, F. Bech-Knudsen, M. Juhola, N.N. Nupponen, S. Laurberg, C.L. Andersen, L. A. Aaltonen, T.F. ORntoft, Gene expression signatures for colorectal cancer microsatellite status and HNPCC. Br. J. Cancer 92, 2240-2248 (2005) (Pubitemid 40966263)
21. P. Hegde, R. Qi, R. Gaspard, K. Abernathy, S. Dharap, J. Earle-Hughes, C. Gay, N.U. Nwokekeh, T. Chen, A.I. Saeed, V. Sharov, N.H. Lee, T.J. Yeatman, J. Quackenbush, Identification of tumor markers in models of human colorectal cancer using a 19,200-element complementary DNA microarray. Cancer Res. 61, 7792-7797 (2001) (Pubitemid 33049366)
22. O. Takata, Y.J. Kawamura, F. Konishi, J. Sasaki, T. Kai, Y.Miyakura, H. Nagai, T. Tsukamoto, cDNA array analysis for prediction of hepatic metastasis of colorectal carcinoma. Surg. Today. 36, 608-614 (2006) (Pubitemid 43962100)
23. G.A. Ganepola, R.M. Mazziotta, D. Weeresinghe, G.A. Corner, C. J. Parish, D.H. Chang, N.C. Tebbutt, C. Murone, N. Ahmed, L.H. Augenlicht, J.M. Mariadason, Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors. Clin. Exp. Metastasis. 27, 1-9 (2010)
24. K.H. Koh, H. Rhee, H.J. Kang, E. Yang, K.T. You, H. Lee, B.S. Min, N.K. Kim, S.W. Nam, H. Kim, Differential gene expression profiles of metastases in paired primary and metastatic colorectal carcinomas. Oncology 75, 92-101 (2008)
25. M. Grade, P. Hormann, S. Becker, A.B. Hummon, D. Wangsa, S. Varma, R. Simon, T. Liersch, H. Becker, M.J. Difilippantonio, B. M. Ghadimi, T. Ried, Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. Cancer Res. 67, 41-56 (2007) (Pubitemid 46142758)
26. A. Barrier, P.Y. Boelle, A. Lemoine, C. Tse, D. Brault, F. Chiappini, F. Lacaine, S. Houry, M. Huguier, A. Flahault, S. Dudoit, Gene expression profiling of nonneoplastic mucosa may predict clinical outcome of colon cancer patients. Dis. Colon Rectum 48, 2238-2248 (2005) (Pubitemid 43074444)
27. D. Arango, P. Laiho, A. Kokko, P. Alhopuro, H. Sammalkorpi, R. Salovaara, D. Nicorici, S. Hautaniemi, H. Alazzouzi, J.P. Mecklin, H. Jarvinen, A. Hemminki, J. Astola, Schwartz S Jr, L.A. Aaltonen, Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer. Gastroenterology 129, 874-884 (2005) (Pubitemid 41242680)
28. E. Bandrés, R. Malumbres, E. Cubedo, B. Honorato, R. Zarate, A. Labarga, U. Gabisu, J.J. Sola, J. Garcia-Foncillas, A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients. Oncol. Rep. 17, 1089-1094 (2007)
29. A. Barrier, P.Y. Boelle, F. Roser, J. Gregg, C. Tse, D. Brault, F. Lacaine, S. Houry, M. Huguier, B. Franc, A. Flahault, A. Lemoine, S. Dudoit, Stage II colon cancer prognosis prediction by tumor gene expression profiling. J. Clin. Oncol. 24, 4685-4691 (2006) (Pubitemid 46630932)
30. M. Del Rio, F. Molina, C. Bascoul-Mollevi, V. Copois, F. Bibeau, P. Chalbos, C. Bareil, A. Kramar, N. Salvetat, C. Fraslon, E. Conseiller, V. Granci, B. Leblanc, B. Pau, P. Martineau, M. Ychou, Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan. J. Clin. Oncol. 25, 773-780 (2007) (Pubitemid 350002876)
31. D.A. Notterman, U. Alon, A.J. Sierk, A.J. Levine, Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res. 61, 3124-3130 (2001) (Pubitemid 32691964)
32. Y.M. Lin, Y. Furukawa, T. Tsunoda, C.T. Yue, K.C. Yang, Y. Nakamura, Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas. Oncogene 21, 4120-4128 (2002) (Pubitemid 34712879)
33. O. Galamb, B. Gyorffy, F. Sipos, S. Spisak, A.M. Nemeth, P. Miheller, Z. Tulassay, E. Dinya, B. Molnar, Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature. Dis. Markers. 25, 1-16 (2008)
34. M. Skrzypczak, K. Goryca, T. Rubel, A. Paziewska, M. Mikula, D. Jarosz, J. Pachlewski, J. Oledzki, J. Ostrowski, Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS. One. 5 (2010)
35. A.H. Sillars-Hardebol, B. Carvalho, M. de Wit, C. Postma, P.M. Delis-van Diemen, S. Mongera, B. Ylstra, M.A. van de Wiel, G.A. Meijer, R.J. Fijneman, Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression. Tumour. Biol. 31, 89-96 (2010)
36. R. Edgar, M. Domrachev, A.E. Lash, Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30, 207-210 (2002) (Pubitemid 34679544)
37. R. Tibshirani, T. Hastie, B. Narasimhan, G. Chu, Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc. Natl. Acad. Sci. U. S. A. 99, 6567-6572 (2002) (Pubitemid 34526173)
38. A. Subramanian, P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, E. S. Lander, J.P. Mesirov, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U. S. A. 102, 15545-15550 (2005) (Pubitemid 41528093)
39. D. Huang, B. Yu, Y. Deng, W. Sheng, Z. Peng, W. Qin, X. Du, SFRP4 was overexpressed in colorectal carcinoma. J. Cancer Res. Clin. Oncol. 136, 395-401 (2010)
40. U. Gerlach, G. Kayser, A. Walch, U. Hopt, J. Schulte-Monting, M. Werner, S. Lassmann, Centrosome-, chromosomal-passenger-and cell-cycle-associated mRNAs are differentially regulated in the development of sporadic colorectal cancer. J. Pathol. 208, 462-472 (2006) (Pubitemid 43336018)
41. C. Grijelmo, C. Rodrigue, M. Svrcek, E. Bruyneel, A. Hendrix, W. O. de, C. Gespach, Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. Cell. Signal. 19, 1722-1732 (2007) (Pubitemid 46935428)
42. T. Tomonaga, K. Matsushita, M. Ishibashi, M. Nezu, H. Shimada, T. Ochiai, K. Yoda, F. Nomura, Centromere protein H is upregulated in primary human colorectal cancer and its overexpression induces aneuploidy. Cancer Res. 65, 4683-4689 (2005) (Pubitemid 40740804)
43. J. Murn, O. Alibert, N. Wu, S. Tendil, X. Gidrol, Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4. J. Exp. Med. 205, 3091-3103 (2008)
44. J.P. Carey, A.J. Asirvatham, O. Galm, T.A. Ghogomu, J. Chaudhary, Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer. BMC Cancer. 9, 173 (2009)
45. T.L. Romanuik, T. Ueda, N. Le, S. Haile, T.M. Yong, T. Thomson, R.L. Vessella, M.D. Sadar, Novel biomarkers for prostate cancer including noncoding transcripts. Am. J. Pathol. 175, 2264-2276 (2009)
46. N. Miyoshi, H. Ishii, M. Sekimoto, Y. Doki, M. Mori, RGS16 is a marker for prognosis in colorectal cancer. Ann. Surg. Oncol. 16, 3507-3514 (2009)
47. K.A. Rees, H. Singh, N.P. Brindle, The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. Int. J. Oncol. 31, 893-897 (2007)
48. L. Tang, D.L. Dai, M. Su, M. Martinka, G. Li, Y. Zhou, Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. Clin. Cancer Res. 12, 3716-3722 (2006) (Pubitemid 44000252)
49. K. Yamaguchi, M. Sakai, T. Shimokawa, Y. Yamada, Y. Nakamura, Y. Furukawa, C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer. Br. J. Cancer 102, 325-331 (2010)
50. H. Satake, K. Tamura, M. Furihata, T. Anchi, H. Sakoda, C. Kawada, T. Iiyama, S. Ashida, T. Shuin, The ubiquitin-like molecule interferon-stimulated gene 15 is overexpressed in human prostate cancer. Oncol. Rep. 23, 11-16 (2010)
51. J. Li, R. Sun, K. Tao, G. Wang, The CCL21/CCR7 pathway plays a key role in human colon cancer metastasis through regulation of matrix metalloproteinase-9. Dig. Liver Dis. (2010)
52. K. Dardousis, C. Voolstra, M. Roengvoraphoj, A. Sekandarzad, S. Mesghenna, J. Winkler, Y. Ko, J. Hescheler, A. Sachinidis, Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells. Mol. Ther. 15, 94-102 (2007) (Pubitemid 46043654)
53. R. Read, G. Hansen, J. Kramer, R. Finch, L. Li, P. Vogel, Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest. Vet. Pathol. 46, 491-504 (2009)
54. S. Ghosh, A. Ghosh, G.P. Maiti, N. Alam, A. Roy, B. Roy, S. Roychoudhury, C.K. Panda, Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis. Int. J. Cancer 123, 2594-2604 (2008)
55. R.A. Hubner, K.R. Muir, J.F. Liu, R.F. Logan, M. Grainge, N. Armitage, V. Shepherd, S. Popat, R.S. Houlston, Genetic variants of UGT1A6 influence risk of colorectal adenoma recurrence. Clin. Cancer Res. 12, 6585-6589 (2006) (Pubitemid 44799734)
56. T. Santarius, J. Shipley, D. Brewer, M.R. Stratton, C.S. Cooper, A census of amplified and overexpressed human cancer genes. Nat. Rev. Cancer 10, 59-64 (2010)
57. S. Sen, H. Katayama, K. Sasai, Functional significance of Aurora kinase A in centrosome amplification and genomic instability. Adv. Exp. Med. Biol. 617, 99-108 (2008)
58. H. Zhou, J. Kuang, L. Zhong,W.L. Kuo, J.W. Gray, A. Sahin, B.R. Brinkley, S. Sen, Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20, 189-193 (1998) (Pubitemid 28455454)
59. J. Chen, L. Ye, F. Xie, Y. Yang, L. Zhang, W.G. Jiang, Expression of bone morphogenetic protein 7 in lung cancer and its biological impact on lung cancer cells. Anticancer. Res. 30, 1113-1120 (2010)
60. C. Morrissey, L.G. Brown, T.E. Pitts, R.L. Vessella, E. Corey, Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. Neoplasia 12, 192-205 (2010)
61. E.L. Alarmo, J. Parssinen, J.M. Ketolainen, K. Savinainen, R. Karhu, A. Kallioniemi, BMP7 influences proliferation, migration, and invasion of breast cancer cells. Cancer Lett. 275, 35-43 (2009)
62. L. Cassar, H. Li, A.R. Pinto, C. Nicholls, S. Bayne, J.P. Liu, Bone morphogenetic protein-7 inhibits telomerase activity, telomere maintenance, and cervical tumor growth. Cancer Res. 68, 9157-9166 (2008)
63. K. Motoyama, F. Tanaka, Y. Kosaka, K. Mimori, H. Uetake, H. Inoue, K. Sugihara, M. Mori, Clinical significance of BMP7 in human colorectal cancer. Ann. Surg. Oncol. 15, 1530-1537 (2008)
64. J.H. Hoeijmakers, DNA damage, aging, and cancer. N. Engl. J. Med. 361, 1475-1485 (2009)
65. T. Kuilman, C. Michaloglou, W.J. Mooi, D.S. Peeper, The essence of senescence. Genes Dev. 24, 2463-2479 (2010)
66. W.J. Mooi, D.S. Peeper, Oncogene-induced cell senescence-halting on the road to cancer. N. Engl. J. Med. 355, 1037-1046 (2006) (Pubitemid 44343547)
67. M.T. Hemann, M. Narita, Oncogenes and senescence: breaking down in the fast lane. Genes Dev. 21, 1-5 (2007) (Pubitemid 46089702)
68. L.C. Vredeveld, B.D. Rowland, S. Douma, R. Bernards, D.S. Peeper, Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E. Carcinogenesis 31, 201-207 (2010)
69. A.R. Davalos, J.P. Coppe, J. Campisi, P.Y. Desprez, Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 29, 273-283 (2010)
70. D. Wang, R.N. DuBois, Pro-inflammatory prostaglandins and progression of colorectal cancer. Cancer Lett. 267, 197-203 (2008)
71. H. Rajagopalan, M.A. Nowak, B. Vogelstein, C. Lengauer, The significance of unstable chromosomes in colorectal cancer. Nat. Rev. Cancer 3, 695-701 (2003) (Pubitemid 37328824)
72. R.J. Fijneman, B. Carvalho, C. Postma, S. Mongera, V.W. van Hinsbergh, G.A. Meijer, Loss of 1p36, gain of 8q24, and loss of 9q34 are associated with stroma percentage of colorectal cancer. Cancer Lett. 258, 223-229 (2007) (Pubitemid 350101027)
73. R.J. Deberardinis, N. Sayed, D. Ditsworth, C.B. Thompson, Brick by brick: metabolism and tumor cell growth. Curr. Opin. Genet. Dev. 18, 54-61 (2008) (Pubitemid 351694453)
74. I. Samudio, R. Harmancey, M. Fiegl, H. Kantarjian, M. Konopleva, B. Korchin, K. Kaluarachchi, W. Bornmann, S. Duvvuri, H. Taegtmeyer, M. Andreeff, Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J. Clin. Invest. 120, 142-156 (2010)
75. V. Fritz, L. Fajas, Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene 29, 4369-4377 (2010)
76. N. Homann, I.R. Konig, M. Marks, M. Benesova, F. Stickel, G. Millonig, S. Mueller, H.K. Seitz, Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1 C polymorphism. Alcohol. Clin. Exp. Res. 33, 551-556 (2009)
77. E.J. Douglas, H. Fiegler, A. Rowan, S. Halford, D.C. Bicknell, W. Bodmer, I.P. Tomlinson, N.P. Carter, Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas. Cancer Res. 64, 4817-4825 (2004) (Pubitemid 38924525)
78. R.P. Brosens, E.J. Belt, J.C. Haan, T.E. Buffart, B. Carvalho, H. Grabsch, P. Quirke, M.A. Cuesta, A.F. Engel, B. Ylstra, G.A. Meijer, Deletion of chromosome 4q predicts outcome in stage II colon cancer patients. Cell. Oncol. 34, 215-223 (2011)