Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

PLoS Computational Biology

Volumn 11, Issue 2, 2015, Pages

  Jolivet, Renaud ^a   Coggan, Jay S ^b,c   Allaman, Igor ^b   Magistretti, Pierre J ^b,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b EPFL   (Switzerland)

^c Neurolinx Research Institute   (United States)

^d KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; BRAIN MAPPING; CHEMICAL ACTIVATION; DYNAMICS; GLUCOSE; METABOLISM; OXYGEN; TISSUE;

ACTIVITY-DEPENDENT; ADULT BRAIN; BIOPHYSICAL MODEL; ENERGY; GLIAL CELLS; METABOLIC COUPLING; NORMAL CONDITION; TEMPORAL DYNAMICS; TIME-SCALES; VASCULATURE;

NEURONS;

GLUCOSE; LACTIC ACID; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SODIUM;

AEROBIC METABOLISM; ARTICLE; ASTROCYTE; BIOPHYSICAL MODEL; BOLD SIGNAL; BRAIN BLOOD VESSEL; BRAIN METABOLISM; ENERGY METABOLISM; GLIA CELL; GLUCOSE UTILIZATION; GLYCOLYSIS; HODGKIN HUXLEY EQUATION; IN VIVO STUDY; MATHEMATICAL MODEL; METABOLIC ACTIVATION; MODEL; NERVE CELL; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE; NEUROIMAGING; NONHUMAN; OXYGEN CONSUMPTION; RAT; TISSUE LEVEL; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; BRAIN; BRAIN CIRCULATION; COMPUTER SIMULATION; EXTRACELLULAR SPACE; HUMAN; METABOLISM; VASCULARIZATION;

RATTUS;

ANIMALS; ASTROCYTES; BRAIN; CEREBROVASCULAR CIRCULATION; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; EXTRACELLULAR SPACE; GLUCOSE; HUMANS; LACTIC ACID; MODELS, CARDIOVASCULAR; MODELS, NEUROLOGICAL; NAD; NEURONS; OXYGEN CONSUMPTION; RATS; SODIUM;

EID: 84924359074     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004036     Document Type: Article

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