Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence

Biogerontology

Volumn 15, Issue 2, 2014, Pages 177-198

  Braidy, Nady ^a   Poljak, Anne ^b   Grant, Ross ^b,c   Jayasena, Tharusha ^a   Mansour, Hussein ^d   Chan Ling, Tailoi ^d   Guillemin, Gilles J ^b,e   Smythe, George ^b   Sachdev, Perminder ^a,b,f  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c SYDNEY ADVENTIST HOSPITAL   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e St Vincent's Centre for Applied Medical Research   (Australia)

^f PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Ageing; DNA damage; Oxidative stress; PARP

Indexed keywords

ADENOSINE TRIPHOSPHATE; CD38 ANTIGEN; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN 1; ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; CD38 PROTEIN, RAT; MEMBRANE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SIRT1 PROTEIN, RAT; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN REGION; BRAIN STEM; CEREBELLUM; FEMALE; HIPPOCAMPUS; LIPID PEROXIDATION; MITOCHONDRIAL RESPIRATION; NERVE CELL; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENESCENCE; AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DNA DAMAGE; ELECTRON TRANSPORT; GENE SILENCING; GENETICS; METABOLISM; MITOCHONDRION; PROTEIN CARBONYLATION; TISSUE DISTRIBUTION; WISTAR RAT;

ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE TRIPHOSPHATE; ADP-RIBOSYL CYCLASE; AGING; ANIMALS; ANTIGENS, CD38; BRAIN; DNA DAMAGE; ELECTRON TRANSPORT; FEMALE; GENE KNOCKDOWN TECHNIQUES; LIPID PEROXIDATION; MEMBRANE GLYCOPROTEINS; MITOCHONDRIA; NAD; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; RNA, SMALL INTERFERING; SIRTUIN 1; TISSUE DISTRIBUTION;

EID: 84896399265     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-013-9489-5     Document Type: Article

References (97)

1. Aarhus R, Graeff RM, Dickey DM, Walseth TF, Lee HC (1995) ADP-ribosyl cyclase and CD38 catalyse the synthesis of a calcium-mobilizing metabolite from NADP. J Biol Chem 270(51):30327-30333
2. Ahmed I, John A, Vijayasarathy C, Robin M, Raza H (2002) Differential modulation of growth and glutathione metabolism in cultured rat astrocytes by 4-hydroxynonenal and green tea polyphenol, epigallocatechin-3-gallate. Neurotoxicology 23:289-300
3. Aksoy P, Escande C, White TA, Thompson M, Soares S, Benech JC, Chini EN (2006a) Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. Biochem Biophys Res Commun 349(1):353-359
4. Aksoy P, White TA, Thompson M, Chini EN (2006b) Regulation of intracellular levels of NAD: a novel role for CD38. Biochem Biophys Res Commun 345(4):1386-1392
5. Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva YK, Salmina AB, Nishimura T, Fakhrul AA, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H (2013) CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice. Mol Brain 6(1):41
6. Alvarez-Gonzalez R, Zentgraf H, Frey M, Hilda M-A (2006) Functional interactions of PARP-1 with p53. Poly(ADP-ribosyl)ation. Springer, New York, pp 61-66
7. Anderson G, Maes M (2013) Neurodegeneration in Parkinson's disease: interactions of oxidative stress, tryptophan catabolites and depression with mitochondria and sirtuins. Mol Neurobiol. doi: 10.1007/s12035-013-8554-z
8. Ashok BT, Ali R (1999) The aging paradox: free radical theory of aging. Exp Gerontol 34(3):293-303
9. Bagul PK, Banerjee SK (2013) Insulin resistance, oxidative stress and cardiovascular complications: role of sirtuins. Curr Pharm Des 19(32):5663-5677
10. Bai P, Canto C (2012) The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease. Cell Metab 16(3):290-295
11. Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120(4):483-495
12. Ban TA (1975) Nicotinic acid in the treatment of schizophrenias. Practical and theoretical considerations. Neuropsychobiology 1(3):133-145
13. Banerjee S, Walseth TF, Borgmann K, Wu L, Bidasee KR, Kannan MS, Ghorpade A (2008) CD38/cyclic ADP-ribose regulates astrocyte calcium signalling: implications for neuroinflammation and HIV-1-associated dementia. J Neuroimmune Pharmacol 3(3):154-164
14. Beach TG, Adler C, Sue L, Vedders L, Lue L, White L (2010) Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 119:689-702
15. Berger F, Lau C, Ziegler M (2007) Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1. Proc Natl Acad Sci USA 104(10):3765-3770
16. Bernofsky C, Swan M (1973) An improved cycling assay for nicotinamide adenine dinucleotide. Anal Biochem 53:452-458
17. Betarbet R, Sherer T, MacKenzie G, Garcia-Osuna M, Panov A, Greenamyre J (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3:1301-1306
18. Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW (2010) Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci 30(17):6058-6071
19. Blalock EM, Buechel HM, Popovic J, Geddes JW, Landfield PW (2011) Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease. J Chem Neuroanat 42(2):118-126
20. Blankfield A (2013) Kynurenine pathway pathologies: do nicotinamide and other pathway co-factors have a therapeutic role in reduction of symptom severity, including chronic fatigue syndrome (CFS) and fibromyalgia (FM). Int J Tryptophan Res 6(Suppl 1):39-45
21. Bohr V (2002) Oxidative DNA damage and repair. Free Radic Biol Med 32(9):804-812
22. Bouchard V, Rouleau M, Poirier GG (2003) PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 31:446-454
23. Bradford MM (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 53:452-458
24. Braidy N, Guillemin G, Grant R (2008) Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease. Neurotox Res 13(3-4):173-184
25. + metabolism, oxidative stress and Sirt1 activity in wistar rats. PLOS One 6(4):e19194
26. Braidy N, Jayasena T, Poljak A, Sachdev PS (2012) Sirtuins in cognitive ageing and Alzheimer's disease. Curr Opin Psychiatry 25(3):226-230
27. Brunetti E, Malavasi F (2012) CD38 and behavior: moving from correlation to causality? Biol Psychiatry 72(3):168-170
28. Burkle A (2005) Poly(ADP-ribose). The most elaborate metabolite of NAD+. FEBS J 272(18):4576-4589
29. Burkle A, Beneke S, Muiras ML (2004) Poly(ADP-ribosyl)ation and aging. Exp Gerontol 39(11-12):1599-1601
30. Butterfield DA (2002) Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic Res 36(12):1307-1313
31. Butterfield DA, Draker J, Pocernich C, Categna A (2001) Evidence of oxidative damage in the Alzheimer's Disease brain:central role of Amyloid β-peptide. Trends Mol Med 7:548-554
32. Canevari L, Clark J, Bates T (1999) β-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett 457:131-134
33. Chen Q, Fischer A, Reagan J, Yan L, Ames B (1995) Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 92(10):4337-4341
34. Chen KC, Blalock EM, Curran-Rauhut MA, Kadish I, Blalock SJ, Brewer L, Porter NM, Landfield PW (2013) Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging. Endocrinology 154(8):2807-2820
35. +-dependent internalization of recombinant CD38 in CHO cells. Arch Biochem Biophys 363(2):267-272
36. Collier TJ, Coleman PD (1991) Divergence of biological and chronological aging: evidence from rodent studies. Neurobiol Aging 12:685-693
37. Craft S, Foster TC, Landfield PW, Maier SF, Resnick SM, Yaffe K (2012) Session III: mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes. J Gerontol A 67(7):754-759
38. Davies S, Poljak A, Duncan M, Smythe G, Murphy M (2001) Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats. Free Radic Biol Med 31:181-190
39. de Marcia G (1994) Poly(ADP-ribose) polymerase: a molecular nick sensor. Trends Biochem Sci 19:172-176
40. Erdelyi K, Bakondi E, Gergely P, Szabo C, Virag L (2005) Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation. Cell Mol Life Sci 62(7-8):751-759
41. + metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes 62(4):1084-1093
42. Farres J, Martin-Caballero J, Martinez C, Lozano JJ, Llacuna L, Ampurdanes C, Ruiz-Herguido C, Dantzer F, Schreiber V, Villunger A, Bigas A, Yelamos J (2013) Parp-2 is required to maintain hematopoiesis following sublethal gamma-irradiation in mice. Blood 122(1):44-54
43. Finkel T (2005) Opinion: radical medicine: treating ageing to cure disease. Nat Rev Mol Cell Biol 6:971-976
44. Floyd RA, Hensley K (2002) Oxidative stress in brain aging: implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23:795-807
45. Grant RS, Kapoor V (1998) Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates. J Neurochem 70:1759-1763
46. + glyohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides. J Biol Chem 271:12951-12955
47. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11(3):298-300
48. Harman D (2003) The free radical theory of aging. Antioxid Redox Signal 5(5):557-561
49. Harper ME, Monemdjou S, Ramsey JJ, Weindruch R (1998) Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. Am J Physiol 275:197-206
50. Huang X, Tanaka T, Kurose A, Traganos F, Darzynkiewicz Z (2006) Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species. Int J Oncol 29:495-501
51. Infante J, Llorca J, Mateo I, Rodriguez-Rodriguez E, Sanchez-Quintana C, Sanchez-Juan P, Fernandez-Viadero C, Pena N, Berciano J, Combarros O (2007) Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk. Dement Geriatr Cogn Disord 23(4):215-218
52. Kamata H, Hirata H (1999) Redox regulation of cellular signalling. Cell Signal 11(1):1-14
53. Keller JN, Mattson MP (1998) Roles of lipid peroxidation in modulation of cellular signalling pathways, cell dysfunction, and death in the nervous system. Rev Neurosci 9(2):105-116
54. Khan JA, Forouhar F, Tao X, Tong L (2007) Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets 11(5):695-705
55. + into a nuclear signal. Genes Dev 19(17):1951-1967
56. Kraus WL, Hottiger MO (2013) PARP-1 and gene regulation: progress and puzzles. Mol Aspects Med 34(6):1109-1123
57. Kruman I, Bruce-Keller A, Bredesen D, Waeg G, Mattson M (1997) Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci 17:5089-5100
58. Kutuzov MM, Khodyreva SN, Ame JC, Ilina ES, Sukhanova MV, Schreiber V, Lavrik OI (2013) Interaction of PARP-2 with DNA structures mimicking DNA repair intermediates and consequences on activity of base excision repair proteins. Biochimie 95(6):1208-1215
59. Landfield PW, Blalock EM, Chen KC, Porter NM (2007) A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease. Curr Alzheimer Res 4(2):205-212
60. Latimer CS, Searcy JL, Bridges MT, Brewer LD, Popovic J, Blalock EM, Landfield PW, Thibault O, Porter NM (2011) Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. PLoS One 6(10):e26812
61. Li J, Holbrook NJ (2003) Common mechanisms for declines in oxidative stress tolerance and proliferation with aging. Free Radic Biol Med 35(3):292-299
62. Lopatina O, Inzhutova A, Salmina AB, Higashida H (2012) The roles of oxytocin and CD38 in social or parental behaviors. Front Neurosci 6:182
63. Love S, Barber R, Wilcock GK (1999) Increased poly(ADP-ribosyl)ation of nuclear proteins in Azheimer's Disease. Brain 122:247-253
64. Maldonado PD, Chanez-Cardenas ME, Barrera D, Villeda-Hernandez J, Santamaria A, Pedraza-Chaverri J (2007) Poly(ADP-ribose) polymerase-1 is involved in the neuronal death induced by quinolinic acid in rats. Neurosci Lett 425(1):28-33
65. + metabolism and oxidative stress: the golden nucleotide on a crown of thorns. Redox Rep 17(1):28-46
66. Mattson MP (2004) Pathway towards and away from Azheimer's Disease. Nature 430:630-639
67. Merksamer PI, Liu Y, He W, Hirschey MD, Chen D, Verdin E (2013) The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) 5(3):144-150
68. Miranda S, Opazo C, Larrondo LF, Munoz FJ, Ruiz F, Leighton F, Inestrosa NC (2000) The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease. Prog Neurobiol 62(6):633-648
69. Moss NG, Vogel PA, Kopple TE, Arendshorst WJ (2013) Thromboxane-induced renal vasoconstriction is mediated by the ADP-ribosyl cyclase CD38 and superoxide anion. Am J Physiol Renal Physiol 305(6):830-838
70. Mutisya E, Bowling A, Beal M (2002) Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J Neurochem 63(6):2179-2184
71. Nadal-Serrano M, Pons DG, Sastre-Serra J, Blanquer-Rossello Mdel M, Roca P, Oliver J (2013) Genistein modulates oxidative stress in breast cancer cell lines according to ERalpha/ERbeta ratio: effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes. Int J Biochem Cell Biol 45(9):2045-2051
72. Nakae D, Akai H, Kishida H, Kusuoka O, Tsutsumi M, Konishi Y (2000) Age and organ dependent spontaneous generation of nuclear 8-hydroxyguanosine in male Fischer 344 rats. Lab Invest 80(2):249-261
73. Nipp RD, Volkheimer AD, Davis ED, Chen Y, Weinberg JB, Friedman DR (2013) CD38 variation as a prognostic factor in chronic lymphocytic leukemia. Leuk Lymphoma. doi: 10.3109/10428194.2013.786070
74. Poljak A, Pamphlett R, Gurney M, Duncan M (2000) Measurement of o- and m-tyrosine as markers of oxidative damage in motor neuron disease. Redox Rep 5:137-140
75. Poljak A, Dawes I, Ingelse B, Duncan M, Smythe G, Grant C (2003) Oxidative damage to proteins in yeast cells exposed to adaptive levels of H(2)O(2). Redox Rep 8:371-377
76. Quarona V, Zaccarello G, Chillemi A, Brunetti E, Singh VK, Ferrero E, Funaro A, Horenstein AL, Malavasi F (2013) CD38 and CD157: a long journey from activation markers to multifunctional molecules. Cytometry B Clin Cytom 84(4):207-217
77. Rebrin I, Sohal R (2004) Comparison of thiol redox state of mitochondria and homogenates of various tissues between two strains of mice with different longevities. Exp Gerontol 39:1513-1519
78. Retz W, Gsell W, Munch L, Riedier P (1998) Free radicals in Alzheimer's disease. J Neurol Transm Suppl 54:221-236
79. Romero FJ, Bosch-Morell F, Romero MJ, Jareno EJ, Romero B, Marin N, Roma J (1998) Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect 106(Suppl 5):1229-1234
80. Rudin DO (1981) The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra. Biol Psychiatry 16(9):837-850
81. Sauve AA, Wolberger C, Schramm VL, Boeke JD (2006) The biochemistry of sirtuins. Annu Rev Biochem 75:435-465
82. Savaskan D, Yurtseven N, Tuygun AK, Aksoy P, Canik S (2006) The effects of insulin given prior to release of cross-clamp on coronary sinus lactate levels in coronary artery surgery. Anadolu Kardiyol Derg 6(3):248-252
83. Schapira A, Cooper J, Dexter D, Jenner P, Marsden C (1989) Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1:1269
84. Schreiber V, Dantzer F, Ame JC, de Murcia G (2006) Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol 7(7):517-528
85. Shinmura K (2013) Effects of caloric restriction on cardiac oxidative stress and mitochondrial bioenergetics: potential role of cardiac sirtuins. Oxid Med Cell Longev 2013:528935
86. + entry by CD38 in human airway smooth muscle. AJP-Lung Cell Mol Physiol 294:L378-L385
87. Smyth LM, Breen LT, Yamboliev IA, Mutafova-Yambolieva VN (2006) Novel localization of CD38 in perivascular sympathetic nerve terminals. Neuroscience 139(4):1467-1477
88. Sobko EA, Kraposhina A, Demko IV, Salmina AB (2013) CD38/ADP-ribosyl cyclase, a marker of endothelial dysfunction in bronchial asthma. Klin Med (Mosk) 91(2):34-38
89. Thibault O, Anderson KL, Demoll C, Brewer LD, Landfield PW, Porter NM (2013) Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. Eur J Pharmacol 719(1-3):34-43
90. + by platelet CD38 in the absence of synthesis and degradation of cyclic ADP-ribose 2′-phosphate. FEBS Lett 455(3):359-363
91. Virag L, Salzman AL, Szabo C (1998) Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J Immunol 161:3753-3759
92. Weidele K, Kunzmann A, Schmitz M, Beneke S, Burkle A (2010) Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells. Biochem Pharmacol 80(7):1103-1112
93. Wu M, Neilson A, Swift A, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S, Ferrick D (2007) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhances glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292:C125-C136
94. Xiong J, Xia M, Yi F, Abais JM, Li N, Boini KM, Li PL (2013) Regulation of renin release via cyclic ADP-ribose-mediated signalling: evidence from mice lacking CD38 gene. Cell Physiol Biochem 31(1):44-55
95. Xu M, Li XX, Ritter JK, Abais JM, Zhang Y, Li PL (2013) Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes. PLoS One 8(8):e71212
96. Zarkovic K (2003) 4-Hydroxynonenal and neurodegenerative diseases. Mol Aspects Med 24(4-5):293-303
97. Zhang J (2003) Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked? Bioessays 25(8):808-814