The effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Jiang, San Hong ^a   Shang, Lei ^a   Xue, Li Xiang ^b   Ding, Wei ^a   Chen, Shuang ^a   Ma, Ruo Fei ^c   Huang, Ju Fang ^a   Xiong, Kun ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c Central South University   (China)

Author keywords

Necroptosis; Oxidative stress; Retinal ganglion cells 5; Timosaponin B II; TNF

Indexed keywords

BIMOSAPONIN B II; HERBACEOUS AGENT; HYDROGEN PEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; SAPONIN; STEROID; TIMOSAPONIN B-II;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; MOUSE; NECROPTOSIS; NONHUMAN; OXIDATIVE STRESS; RETINA GANGLION CELL; ANIMAL; APOPTOSIS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; LILIACEAE; METABOLISM; NECROSIS; PATHOLOGY; RHIZOME;

ANIMALS; APOPTOSIS; CELL SURVIVAL; DRUGS, CHINESE HERBAL; HYDROGEN PEROXIDE; LILIACEAE; MICE; NECROSIS; OXIDATIVE STRESS; RETINAL GANGLION CELLS; RHIZOME; SAPONINS; STEROIDS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84924325493     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-459     Document Type: Article

References (46)

1. Wu W, Liu P, Li J: Necroptosis: an emerging form of programmed cell death. Crit Rev Oncol Hematol 2012,82(3):249-258. 10.1016/j.critrevonc.2011.08.004.
2. Han J, Zhong CQ, Zhang DW: Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol 2011,12(12):1143-1149. 10.1038/ni.2159.
3. Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M: The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 2011,35(4):572-582. 10.1016/j.immuni.2011.08.014.
4. Song KJ, Jang YS, Lee YA, Kim KA, Lee SK, Shin MH: Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri. Parasite Immunol 2011,33(7):390-400. 10.1111/j.1365-3024.2011.01297.x.
5. Wu YT, Tan HL, Huang Q, Sun XJ, Zhu X, Shen HM: zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFalpha mediated by the PKC-MAPKs-AP-1 pathway. Cell Death Differ 2011,18(1):26-37. 10.1038/cdd.2010.72.
6. Vanlangenakker N, Bertrand MJ, Bogaert P, Vandenabeele P, Vanden Berghe T: TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis 2011, 2:e230. 10.1038/cddis.2011.111.
7. Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, Takahashi N, Sergent O, Lagadic-Gossmann D, Vandenabeele P, Samson M, Dimanche-Boitrel MT: TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ 2012,19(12):2003-2014. 10.1038/cdd.2012.90.
8. Vieira M, Fernandes J, Carreto L, Anuncibay-Soto B, Santos M, Han J, Fernandez-Lopez A, Duarte CB, Carvalho AL, Santos AE: Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3. Neurobiol Dis 2014, 68C:26-36.
9. Chen WW, Yu H, Fan HB, Zhang CC, Zhang M, Zhang C, Cheng Y, Kong J, Liu CF, Geng D, Xu X: RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons. J Neurochem 2012,120(1):70-77. 10.1111/j.1471-4159.2011.07526.x.
10. Viringipurampeer IA, Shan X, Gregory-Evans K, Zhang JP, Mohammadi Z, Gregory-Evans CY: Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. Cell Death Differ 2014,21(5):665-675. 10.1038/cdd.2013.191.
11. Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI: Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res 2010,88(7):1569-1576.
12. Dvoriantchikova G, Degterev A, Ivanov D: Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage. Exp Eye Res 2014, 123C:1-7.
13. Huang JF, Shang L, Zhang MQ, Wang H, Chen D, Tong JB, Huang H, Yan XX, Zeng LP, Xiong K: Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response. BMC Neurosci 2013, 14:16. 10.1186/1471-2202-14-16.
14. Shang L, Huang J-F, Ding W, Chen S, Xue L-X, Ma R-F, Xiong K: Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure. BMC Neurosci 2014,15(1):63. 10.1186/1471-2202-15-63.
15. Daoud A, Song J, Xiao F, Shang J: B-9-3, a novel beta-carboline derivative exhibits anti-cancer activity via induction of apoptosis and inhibition of cell migration in vitro. Eur J Pharmacol 2014, 724:219-230.
16. Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD: Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorg Med Chem Lett 2012,22(17):5685-5688. 10.1016/j.bmcl.2012.06.098.
17. Wang K, Li J, Degterev A, Hsu E, Yuan J, Yuan C: Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett 2007,17(5):1455-1465. 10.1016/j.bmcl.2006.11.056.
18. Zheng W, Degterev A, Hsu E, Yuan J, Yuan C: Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett 2008,18(18):4932-4935. 10.1016/j.bmcl.2008.08.058.
19. Wu Z, Li Y, Cai Y, Yuan J, Yuan C: A novel necroptosis inhibitor-necrostatin-21 and its SAR study. Bioorg Med Chem Lett 2013,23(17):4903-4906. 10.1016/j.bmcl.2013.06.073.
20. Xing J, Yi-fan F: Advances in studies on saponins in Anemarrhena asphodeloides. Chinese Tradit Herbal Drugs 2010,41(4):supl12-15.
21. Li TJ, Qiu Y, Yang PY, Rui YC, Chen WS: Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats. Neurosci Lett 2007,421(2):147-151. 10.1016/j.neulet.2007.04.082.
22. Kim JY, Shin JS, Ryu JH, Kim SY, Cho YW, Choi JH, Lee KT: Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem Toxicol 2009,47(7):1610-1617. 10.1016/j.fct.2009.04.009.
23. Zhang J, Zhang M, Sugahara K, Sagara Y, Meng Z, Xu S, Kodama H: Effect of steroidal saponins of Anemarrhenae rhizoma on superoxide generation in human neutrophils. Biochem Biophys Res Commun 1999,259(3):636-639. 10.1006/bbrc.1999.0831.
24. Kaname N, Zhang J, Meng Z, Xu S, Sugahara K, Doi Y, Kodama H: Effect of timosaponin E1 and E2 on superoxide generation induced by various stimuli in human neutrophils and on platelet aggregation in human blood. Clin Chim Acta 2000,295(1-2):129-140.
25. Yun D, Bai-ping M, Yu-wen C, Yu-xian S, Jing-jing Z, Yu-jun S: Protective effects of timosaponin BII on primary neurons against beta amyloid peptide 25-35. Chinese Pharmacol Bull 2009, 02:244-247.
26. Yun D, Qiuping X, Zhenquan L, Baiping M, Chengqi X, Yang Z: Protective effects of saponin compound from anemarrhena asphodeloides on rat undergone cerebral ischemia/reperfusion. J Beijing Univ Tradit Chinese Med 2005, 02:33-35.
27. Huang JF, Shang L, Liu P, Zhang MQ, Chen S, Chen D, Fan CL, Wang H, Xiong K: Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina. BMC Complement Altern Med 2012, 12:189. 10.1186/1472-6882-12-189.
28. Li GY, Li T, Fan B, Zheng YC, Ma TH: The D(1) dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways. Mol Vis 2012, 18:2882-2895.
29. Zhang F, Zhan Q, Gao S, Dong X, Jiang B, Sun L, Tao X, Chen WS: Chemical profile- and pharmacokinetics-based investigation of the synergistic property of platycodonis radix in traditional Chinese medicine formula Shengxian decoction. J Ethnopharmacol 2014,152(3):497-507. 10.1016/j.jep.2014.01.033.
30. Tsai CH, Yang CW, Wang JY, Tsai YF, Tseng LM, King KL, Chen WS, Chiu JH, Shyr YM: Timosaponin AIII Suppresses Hepatocyte Growth Factor-Induced Invasive Activity through Sustained ERK Activation in Breast Cancer MDA-MB-231 Cells. Evid Based Complement Alternat Med 2013, 2013:421051.
31. Laster SM, Wood JG, Gooding LR: Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J Immunol 1988,141(8):2629-2634.
32. Liang X, Chen Y, Zhang L, Jiang F, Wang W, Ye Z, Liu S, Yu C, Shi W: Necroptosis, a novel form of caspase-independent cell death, contributes to renal epithelial cell damage in an ATP-depleted renal ischemia model. Mol Med Rep 2014,10(2):719-724.
33. Lin W, Tongyi S: Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells. Tumour Biol 2014,35(8):8065-8075. 10.1007/s13277-014-2064-0.
34. Sawai H: Characterization of TNF-induced caspase-independent necroptosis. Leuk Res 2014,38(6):706-713. 10.1016/j.leukres.2014.02.002.
35. Lu WQ, Qiu Y, Li TJ, Tao X, Sun LN, Chen WS: Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells. Arch Pharm Res 2009,32(9):1301-1308. 10.1007/s12272-009-1916-4.
36. Miura T, Ichiki H, Iwamoto N, Kato M, Kubo M, Sasaki H, Okada M, Ishida T, Seino Y, Tanigawa K: Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside. Biol Pharm Bull 2001,24(9):1009-1011. 10.1248/bpb.24.1009.
37. Li Y: The protective effects of TSA after cerebral ischemia in rats. Master Degree. Beijing: Beijing University of Chinese Medicine 2010.
38. Guo C, Li L, Yang X, Meng Z, Li F, Zhang C, Yang Z: Protective effects of timosaponin B-II on high glucose-induced apoptosis in human umbilical vein endothelial cells. Environ Toxicol Pharmacol 2014,37(1):37-44. 10.1016/j.etap.2013.11.009.
39. Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T: The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal 2010,3(115):re4.
40. Zhang DW, Zheng M, Zhao J, Li YY, Huang Z, Li Z, Han J: Multiple death pathways in TNF-treated fibroblasts: RIP3-and RIP1-dependent and independent routes. Cell Res 2011,21(2):368-371. 10.1038/cr.2011.3.
41. King FW, Fong S, Griffin C, Shoemaker M, Staub R, Zhang YL, Cohen I, Shtivelman E: Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One 2009,4(9):e7283. 10.1371/journal.pone.0007283.
42. Wang N, Feng Y, Zhu M, Siu FM, Ng KM, Che CM: A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma. Biochim Biophys Acta 2013,1833(12):2890-2899. 10.1016/j.bbamcr.2013.07.018.
43. Sy LK, Yan SC, Lok CN, Man RY, Che CM: Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells. Cancer Res 2008,68(24):10229-10237. 10.1158/0008-5472.CAN-08-1983.
44. Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA: BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation. Cell Death Differ 2012,19(2):245-256. 10.1038/cdd.2011.91.
45. Shulga N, Pastorino JG: Mitoneet mediates TNFalpha-induced necroptosis promoted by exposure to fructose and ethanol. J Cell Sci 2014,127(Pt 4):896-907.
46. Sosna J, Voigt S, Mathieu S, Kabelitz D, Trad A, Janssen O, Meyer-Schwesinger C, Schutze S, Adam D: The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. Cell Commun Signal 2013, 11:76. 10.1186/1478-811X-11-76.