Effect of timosaponin E1 and E2 on superoxide generation induced by various stimuli in human neutrophils and on platelet aggregation in human blood

Clinica Chimica Acta

Volumn 295, Issue 1-2, 2000, Pages 129-140

  Kaname, Noriyoshi ^a   Zhang, Jianying ^b   Meng, Zhiyun ^c   Xu, Suixu ^c   Sugahara, Kazunori ^a   Doi, Yoshinori ^a   Kodama, Hiroyuki ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anemarrhenae rhizoma; Neutrophils; Platelet aggregation; Superoxide; Timosaponin

Indexed keywords

ARACHIDONIC ACID; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GENISTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SAPONIN; STAUROSPORINE; SUPEROXIDE; TIMOSAPONIN E1; TIMOSAPONIN E2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PHYTOCHEMISTRY; PLANT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE AGGREGATION;

BLOOD PROTEINS; CARBOHYDRATE SEQUENCE; HEMOLYSIS; HUMANS; NEUTROPHILS; PHOSPHORYLATION; PLATELET AGGREGATION INHIBITORS; SAPONINS; STEROIDS; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE; TYROSINE;

ANEMARRHENAE; ANEMARRHENAE RHIZOMA; RHIZOMA;

EID: 0034026274     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(00)00196-0     Document Type: Article

References (26)

1. Takahashi M., Konno C., Hikino H. Isolation and hypoglycemic activity of Anemarans A, B, C and D, glycans of Anemarrhenae asphodeloides rhizomes. Planta Med. 51:1985;100-102.
2. Niwa A., Takeda O., Ishimaru M., et al. Screening test for platelet aggregation inhibitor in natural products. The active prenuple of Anemarrhenae rhizoma. Yakugaku Zasshi. 108:1988;555-561.
3. Bhattacharya S.K., Ghosal S., Chaudhori R.K., Sanyal A.K. Canscora decussata (Gentianaceae) xanthones. 3. Pharmacological studies. J Pharm Sci. 61:1971;1838-1840.
4. Kawasaki T., Yamauchi Y., Itakura N. Saponins of Timo (Anemarrhenae rhizoma), I. Yakugaku Zasshi. 81:1963;892-896.
5. Kawasaki T., Yamauchi T. Saponins of Timo (Anemarrhenae rhizoma), II. Structure of Timosaponin A-III. Chem Pharm Bull. 11:1963;1221-1224.
6. Morita N., Shimizu M., Fukuda M. Studies on the medical resources. XXIV. Chimonin in Anemarrhenae rhizoma. Yakugaku Zasshi. 85:1965;374-375.
7. Nagumo S., Kishi S., Inoue I., Nagai M. Saponins of Anemarrhenae rhizoma. Yakugaku Zasshi. 111:1991;306-310.
8. Meng Z., Xu S. Saponins of Anemarrhenae asphodeloides Bge. Chin J Med Chem. 8:(2):1998;135-140.
9. Zhang J., Zhang M., Ma D., Meng Z., Xu S., Kodama H. Effect of six steroidal saponins isolated from Anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood. Clin Chim Acta. 289:1999;79-88.
10. Saito S., Nagase S., Ichinose K. New steroidal saponins from the rhizomes of Anemarrhenae asphodeloides Bge (Liliaceae). Chem Pharm Bull. 42:(11):1994;2342-2345.
11. Goldstein I.M., Roos D., Kaplan H.B., Weissmann G. Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis. J Clin Invest. 56:1975;1155-1163.
12. - forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function. Biochim Biophys Acta. 853:1986;65-89.
13. Takahashi R., Edashige K., Sato E.F., Inoue M., Matsuno T., Utsumi K. Luminol chemi-luminescence and active oxygen generation by activated neutrophils. Arch Biochem Biophys. 285:1991;325-330.
14. McCall C.E., Bass D.A., Dechatelt L.R. Jr., Link A.S., Mann M. In vitro responses of human neutrophils to N-formyl-methionyl-leucyl-phenylalanine: correlation with effects of acute bacterial infection. J Infect Dis. 140:1979;277-286.
15. Kodama H., Yao K., Kobayashi K., et al. New sulfur-containing amino acids in the urine of cystathioninuric patients. Physiol Chem Phys. 1:1969;72-76.
16. Kodama H., Ishimoto Y., Shimomura Y., Hirota M., Ohomori S. Isolation of two new sulfur-containing amino acids from the urine of cystathioninuric patients. Physiol Chem Phys. 7:1975;147-152.
17. Cavallini D., Ricci G., Duprè S., et al. Sulfur-containing cyclic ketimines and imino acids. A novel family of endogenous products in the search for a role. Eur J Biochem. 202:1991;217-223.
18. Zhang J., Sugahara K., Sagara Y., Fontana M., Duprè S., Kodama H. Effect of cystathionine ketimine on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors. Biochem Biophys Res Commun. 218:1996;371-376.
19. Shimazaki Y., Zhang J., Wakiguchi H., et al. Different effect of diastereoisomers of L-cystathionine sulfoxide on the stimulus coupled responses of human neutrophils. Biochem Biophys Res Commun. 247:1998;387-391.
20. Zhang J., Sagara Y., Fontana M., Duprè S., Cavallini D., Kodama H. Effects of cystathionine and cystathionine metabolites on the phosphorylation of tyrosine residues in human neutrophils. Biochem Biophys Res Commun. 224:1996;849-854.
21. Weiss S.J., Klein R., Slivka A., Wei M. Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. J Clin Invest. 70:1982;598-607.
22. Yamamoto M., Saeki K., Utsumi K. Isolation of human salivary polymorphonuclear leukocytes and their stimulation-coupled responses. Arch Biochem Biophys. 289:1992;76-82.
23. Utsumi T., Klostergaard J., Akimaru K., Edashige K., Sato E.F., Utsumi K. Modulation of TNF-α-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors. Arch Biochem Biophys. 294:1992;271-278.
24. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage. Nature. 227:1970;680-685.
25. Ito O., Zhang J., Zhang M., et al. Priming effect of N-acetyl-S-(3-oxo-3-carboxy-n-propyl) cysteine in human neutrophils and tyrosyl phosphorylation of 45 kDa protein. Clin Chim Acta. 266:1997;93-104.
26. Schneider C., Zanetti M., Romeo D. Surface-reactive stimuli selectively increase protein phosphorylation in human neutrophils. FEBS Lett. 127:1981;4-8.