Coenzyme Q10 inhibits the aging of mesenchymal stem cells induced by D-galactose through Akt/mTOR signaling

Oxidative Medicine and Cellular Longevity

Volumn 2015, Issue , 2015, Pages

  Zhang, Dayong ^a   Yan, Bingxi ^a   Yu, Shanshan ^a   Zhang, Chong ^a   Wang, Baoming ^a   Wang, Yayan ^a   Wang, Junbo ^a   Yuan, Zhanggen ^a   Zhang, Lihuang ^a   Pan, Jianping ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELLS; COENZYMES; CYTOLOGY; MOBILE SECURITY; STEM CELLS;

CELL NUMBER; CELL SENESCENCES; COENZYME Q10; CONTROL GROUPS; D-GALACTOSE; MESENCHYMAL STEM CELL; REACTIVE OXYGEN SPECIES; ROS GENERATIONS;

CELL SIGNALING;

CYCLIN DEPENDENT KINASE INHIBITOR 2A; GALACTOSE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UBIDECARENONE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; TARGET OF RAPAMYCIN KINASE; UBIQUINONE;

ANIMAL CELL; ARTICLE; CELL AGING; CONTROLLED STUDY; FLUORESCENCE; FOLLOW UP; MESENCHYMAL STEM CELL; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BONE MARROW CELL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; BONE MARROW CELLS; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GALACTOSE; MESENCHYMAL STROMAL CELLS; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53; UBIQUINONE;

EID: 84924259394     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2015/867293     Document Type: Article

References (67)

1. I. J. Fox, G. Q. Daley, S. A. Goldman, J. Huard, T. J. Kamp, and M. Trucco, "Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease," Science, vol. 345, no. 6199, Article ID 1247391, 2014.
2. F. Z. Asumda, "Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging," Stem Cell Research &Therapy, vol. 4, no. 3, article 47, 2013.
3. S. Ishikane, H. Hosoda, K. Yamahara et al. , "Allogeneic transplantation of fetal membrane-derived mesenchymal stem cell sheets increases neovascularization and improves cardiac function aftermyocardial infarction in rats," Transplantation, vol. 96, no. 8, pp. 697-706, 2013.
4. E. U. Alt, C. Senst, S. N. Murthy et al. , "Aging alters tissue resident mesenchymal stemcell properties," Stem Cell Research, vol. 8, no. 2, pp. 215-225, 2012.
5. C.-H. Ting, P.-J. Ho, and B. L. Yen, "Age-related decreases of serum-response factor levels in humanmesenchymal stem cells are involved in skeletal muscle differentiation and engraftment capacity," Stem Cells and Development, vol. 23, no. 11, pp. 1206-1216, 2014.
6. M. Khan, S. Mohsin, S. N. Khan, and S. Riazuddin, "Repair of senescentmyocardiumbymesenchymal stem cells is dependent on the age of donor mice," Journal of Cellular and Molecular Medicine, vol. 15, no. 7, pp. 1515-1527, 2011.
7. D.-Y. Zhang, H.-J. Wang, and Y.-Z. Tan, "Wnt/-Catenin signaling induces the aging of Mesenchymal stem cells through the DNA damage response and the P53/P21 pathway," PLoS ONE, vol. 6, no. 6, Article ID e21397, 2011.
8. H. Song, M.-J. Cha, B.-W. Song et al. , "Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex," Stem Cells, vol. 28, no. 3, pp. 555-563, 2010.
9. A. Borodkina, A. Shatrova, P. Abushik, N. Nikolsky, and E. Burova, "Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells," Aging, vol. 6, no. 6, pp. 481-495, 2014.
10. L. Shao, H. Li, S. K. Pazhanisamy, A. Meng, Y. Wang, and D. Zhou, "Reactive oxygen species and hematopoietic stem cell senescence," International Journal of Hematology, vol. 94, no. 1, pp. 24-32, 2011.
11. E. T. Ishikawa, D. Gonzalez-Nieto, G. Ghiaur et al. , "Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells," Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 23, pp. 9071-9076, 2012.
12. D. Y. Zhang, Y. Pan, C. Zhang et al. , "Wnt/beta-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production," Molecular and Cellular Biochemistry, vol. 374, no. 1-2, pp. 13-20, 2013.
13. J. Garrido-Maraver, M. D. Cordero, M. Oropesa-Avila et al. , "Coenzyme q10 therapy,"Molecular Syndromology, vol. 5, no. 3-4, pp. 187-197, 2014.
14. J. L. Quiles, J. J. Ochoa, J. R. Huertas, and J. Mataix, "Coenzyme Q supplementation protects from age-related DNA doublestrand breaks and increases lifespan in rats fed on a PUFA-rich diet," ExperimentalGerontology, vol. 39,no. 2, pp. 189-194, 2004.
15. J. Garrido-Maraver, M. D. Cordero, M. Oropesa-Avila et al. , "Clinical applications of coenzyme Q10," Frontiers in Bioscience (Landmark Edition), vol. 19, pp. 619-633, 2014.
16. K. Muthukumaran, S. Leahy, K. Harrison et al. , "Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks ongoing neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease," BMC Neuroscience, vol. 15, article 21, 2014.
17. Y. H. Noh, K.-Y. Kim, M. S. Shim et al. , "Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes," Cell Death and Disease, vol. 4, no. 10, article e820, 2013.
18. R. Sandhir, N. Sethi, A. Aggarwal, and A. Khera, "Coenzyme Q10 treatment ameliorates cognitive deficits by modulating mitochondrial functions in surgically induced menopause," Neurochemistry International, vol. 74, pp. 16-23, 2014.
19. C.-C. Chen, S.-W. Liou, W.-C. Chen, F.-R. Hu, I.-J. Wang, and S.-J. Lin, "Coenzyme Q10 reduces ethanol-induced apoptosis in corneal fibroblasts," PLoS ONE, vol. 6, no. 4, Article ID e19111, 2011.
20. C. Hofman-Bang, N. Rehnqvist, K. Swedberg, I. Wiklund, and H. Astrm, "Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group," Journal of Cardiac Failure, vol. 1, no. 2, pp. 101-107, 1995.
21. J. Naderi, M. Somayajulu-Nitu, A. Mukerji et al. , "Watersoluble formulation of Coenzyme Q10 inhibits Bax-induced destabilization ofmitochondria inmammalian cells," Apoptosis, vol. 11, no. 8, pp. 1359-1369, 2006.
22. C. Cleren, L. Yang, B. Lorenzo et al. , "Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism," Journal ofNeurochemistry, vol. 104, no. 6, pp. 1613-1621, 2008.
23. L. Yang, N. Y. Calingasan, E. J. Wille et al. , "Combination therapy with Coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases," Journal of Neurochemistry, vol. 109, no. 5, pp. 1427-1439, 2009.
24. L. Zeng, Y. Yang, Y. Hu et al. , "Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model," PLoS ONE, vol. 9, no. 2, Article ID e88019, 2014.
25. T. Blatt and G. P. Littarru, "Biochemical rationale and experimental data on the antiaging properties of CoQ10 at skin level," BioFactors, vol. 37, no. 5, pp. 381-385, 2011.
26. J. L. Tarry-Adkins, H. L. Blackmore, M. S. Martin-Gronert et al. , "Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth,"MolecularMetabolism, vol. 2, no. 4, pp. 480-490, 2013.
27. R. A. Shetty, M. J. Forster, and N. Sumien, "Coenzyme Q10 supplementation reverses age-related impairments in spatial learning and lowers protein oxidation," Age, vol. 35, no. 5, pp. 1821-1834, 2013.
28. B. Gharibi, S. Farzadi, M. Ghuman, and F. J. Hughes, "Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells," Stem Cells, vol. 32, no. 8, pp. 2256-2266, 2014.
29. L. S. Steelman, W. H. Chappell, S. L. Abrams et al. , "Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging," Aging, vol. 3, no. 3, pp. 192-222, 2011.
30. S. Liu, S. Liu, X. Wang et al. , "The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro," Aging Cell, vol. 10, no. 4, pp. 661-674, 2011.
31. K. Maiese, Z. Z. Chong, S. Wang, and Y. C. Shang, "Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade," International Journal of Molecular Sciences, vol. 13, no. 11, pp. 13830-13866, 2012.
32. J. Wan, T. Liu, L. Mei et al. , "Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling," British Journal of Cancer, vol. 109, no. 2, pp. 342-350, 2013.
33. Z. Darzynkiewicz, H. Zhao, H. D. Halicka et al. , "In search of antiaging modalities: evaluation of mTOR-and ROS/DNA damage-signaling by cytometry," Cytometry Part A, vol. 85, no. 5, pp. 386-399, 2014.
34. J. H. Park, J. J. Kim, and Y.-S. Bae, "Involvement of PI3K-AKTmTOR pathway in protein kinase CKII inhibition-mediated senescence in human colon cancer cells," Biochemical and Biophysical Research Communications, vol. 433, no. 4, pp. 420-425, 2013.
35. S. Wakao, Y. Kuroda, F. Ogura, T. Shigemoto, and M. Dezawa, "Regenerative effects of mesenchymal stem cells: contribution of muse cells, a novel pluripotent stem cell type that resides in mesenchymal cells," Cells, vol. 1, no. 4, pp. 1045-1060, 2012.
36. C.-H. Lin and B. Lilly, "Endothelial cells direct mesenchymal stem cells toward a smooth muscle cell fate," Stem Cells and Development, vol. 23, no. 21, pp. 2581-2590, 2014.
37. M. Mohammadian, K. Shamsasenjan, P. L. Nezhad et al. , "Mesenchymal stem cells: new aspect in cell-based regenerative therapy," Advanced Pharmaceutical Bulletin, vol. 3, no. 2, pp. 433-437, 2013.
38. M. Krampera, M. Franchini, G. Pizzolo, and G. Aprili, "Mesenchymal stem cells: from biology to clinical use," Blood Transfusion, vol. 5, no. 3, pp. 120-129, 2007.
39. M. Tom, J. C. Seplveda,M. Delgado et al. , "miR-335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity," Stem Cells, vol. 32, no. 8, pp. 2229-2244, 2014.
40. C. Raggi and A. C. Berardi, "Mesenchymal stem cells, aging and regenerative medicine," Muscles, Ligaments and Tendons Journal, vol. 2, no. 3, pp. 239-242, 2012.
41. K.-R. Yu and K.-S. Kang, "Aging-related genes in mesenchymal stem cells: a mini-review," Gerontology, vol. 59, no. 6, pp. 557-563, 2013.
42. J. Wu, J. Niu, X. Li, X. Wang, Z. Guo, and F. Zhang, "TGF-1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production," BMC Developmental Biology, vol. 14, no. 1, article 21, 2014.
43. X. Feng, J. Xing, G. Feng et al. , "p16(INK4A)mediates agerelated changes in mesenchymal stemcells derived fromhuman dental pulp through the DNA damage and stress response," Mechanisms of Ageing and Development, vol. 141-142, pp. 46-55, 2014.
44. C. Holzwarth, M. Vaegler, F. Gieseke et al. , "Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells," BMC Cell Biology, vol. 11, article 11, 2010.
45. L. Basciano, C. Nemos, B. Foliguet et al. , "Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status," BMC Cell Biology, vol. 12, article 12, 2011.
46. A. Mohyeldin, T. Garzn-Muvdi, and A. Quiñones-Hinojosa, "Oxygen in stem cell biology: a critical component of the stem cell niche," Cell Stem Cell, vol. 7, no. 2, pp. 150-161, 2010.
47. S. V. Boregowda, V. Krishnappa, J. W. Chambers et al. , "Atmospheric oxygen inhibits growth and differentiation of marrowderived mouse mesenchymal stem cells via a p53-dependent mechanism: implications for long-term culture expansion," Stem Cells, vol. 30, no. 5, pp. 975-987, 2012.
48. C. Fehrer, R. Brunauer, G. Laschober et al. , "Reduced oxygen tension attenuates differentiation capacity of humanmesenchymal stemcells and prolongs their lifespan," Aging Cell, vol. 6, no. 6, pp. 745-757, 2007.
49. S. Zhang, Z. Dong, Z. Peng, and F. Lu, "Anti-aging effect of adipose-derived stem cells in a mouse model of skin aging induced by D-galactose," PLoS ONE, vol. 9, no. 5, Article ID e97573, 2014.
50. X. Xie, H. Zhang, P. Gao et al. , "Overexpression of SIRT6 in porcine fetal fibroblasts attenuates cytotoxicity and premature senescence caused by D-galactose and tert-butylhydroperoxide," DNA and Cell Biology, vol. 31, no. 5, pp. 745-752, 2012.
51. Y.-N. Li, Y. Guo, M.-M. Xi et al. , "Saponins fromAralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways," Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 320513, 13 pages, 2014.
52. B. Yan, S. Yu, X. Feng et al. , "Effects of D-galactose on ageing of rat mesenchymal stem cells," Zhejiang Da Xue Xue Bao Yi Xue Ban, vol. 42, no. 6, pp. 625-631, 2013.
53. L. Jing, M. T. He, Y. Chang et al. , "Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway," International Journal of Biological Sciences, vol. 11, no. 1, pp. 59-66, 2015.
54. M. Durn-Prado, J. Frontiñn, R. Santiago-Mora et al. , "Coenzyme Q10 protects human endothelial cells from-amyloid uptake and oxidative stress-induced injury," PLoS ONE, vol. 9, no. 10, Article ID e109223, 2014.
55. K. Sugahara, Y. Hirose, T. Mikuriya et al. , "Coenzyme Q10 protects hair cells against aminoglycoside," PLoS ONE, vol. 9, no. 9, Article IDe108280, 2014.
56. K. E. Duberley, S. J. Heales,A. Y. Abramov et al. , "Effect ofCoenzymeQ 10 supplementation onmitochondrial electron transport chain activity and mitochondrial oxidative stress in Coenzyme Q10 deficient human neuronal cells," The International Journal of Biochemistry & Cell Biology, vol. 50, pp. 60-63, 2014.
57. S. McCarthy, M. Somayajulu, M. Sikorska, H. Borowy-Borowski, and S. Pandey, "Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10," Toxicology and Applied Pharmacology, vol. 201, no. 1, pp. 21-31, 2004.
58. M. Somayajulu, S. McCarthy, M. Hung,M. Sikorska, H. Borowy-Borowski, and S. Pandey, "Role of mitochondria in neuronal cell death induced by oxidative stress; Neuroprotection by Coenzyme Q10," Neurobiology of Disease, vol. 18, no. 3, pp. 618-627, 2005.
59. B. K. Binukumar,N. Gupta, A. Bal, and K. D. Gill, "Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic Coenzyme Q10 pretreatment," Toxicology and Applied Pharmacology, vol. 256, no. 1, pp. 73-82, 2011.
60. D. Ma, K. Stokes, K. Mahngar, D. Domazet-Damjanov, M. Sikorska, and S. Pandey, "Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10," Mitochondrion, vol. 17, pp. 106-115, 2014.
61. C. R. Reczek and N. S. Chandel, "ROS-dependent signal transduction," Current Opinion in Cell Biology C, vol. 33, pp. 8-13, 2014.
62. H. Wang, L. Wang, N.-L. Li et al. , "Subanesthetic isoflurane reduces zymosan-induced inflammation in murine Kupffer cells by inhibiting ROS-activated p38 MAPK/NF-B signaling," OxidativeMedicine and Cellular Longevity, vol. 2014,Article ID 851692, 13 pages, 2014.
63. K. Bishayee, A. Paul, S. Ghosh et al. , "Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells," Molecular and Cellular Biochemistry, vol. 382, no. 1-2, pp. 173-183, 2013.
64. J. Li, F. Qiu, L. Yu, Y. Zhao, G. Fu, and B. Zhou, "Thymosin 4 reduces senescence of endothelial progenitor cells via the PI3K/Akt/eNOS signal transduction pathway," Molecular Medicine Reports, vol. 7, no. 2, pp. 598-602, 2013.
65. R. M. Castilho, C. H. Squarize, L. A. Chodosh, B. O. Williams, and J. S. Gutkind, "mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging," Cell Stem Cell, vol. 5, no. 3, pp. 279-289, 2009.
66. S. Shin, K. Jing, S. Jeong et al. , "The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53," BioMed Research International, vol. 2013, Article ID 568671, 11 pages, 2013.
67. H. Zhang, X. Kong, J. Kang et al. , "Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells," Toxicological Sciences, vol. 110, no. 2,pp. 376-388, 2009.