Rational design of allosteric regulation of homoserine dehydrogenase by a nonnatural inhibitor l -lysine

ACS Synthetic Biology

Volumn 4, Issue 2, 2015, Pages 126-131

  Chen, Zhen ^a   Rappert, Sugima ^a   Zeng, An Ping ^a  

^a HAMBURG UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

allosteric regulation; dynamic flux control; homoserine dehydrogenase; lysine; protein design

Indexed keywords

HOMOSERINE DEHYDROGENASE; ISOLEUCINE; LYSINE; THREONINE; ENZYME INHIBITOR; PROTEIN BINDING; RECOMBINANT PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; BIOSYNTHESIS; CORYNEBACTERIUM GLUTAMICUM; MUTAGENESIS; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CORYNEBACTERIUM; DRUG DESIGN; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR DYNAMICS; PROTEIN ENGINEERING;

CORYNEBACTERIUM GLUTAMICUM;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; BINDING SITES; CORYNEBACTERIUM; DRUG DESIGN; ENZYME INHIBITORS; HOMOSERINE DEHYDROGENASE; ISOLEUCINE; KINETICS; LYSINE; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; THREONINE;

EID: 84924257528     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/sb400133g     Document Type: Article

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