Integrating molecular dynamics and co-evolutionary analysis for reliable target prediction and deregulation of the allosteric inhibition of aspartokinase for amino acid production

Journal of Biotechnology

Volumn 154, Issue 4, 2011, Pages 248-254

  Chen, Zhen ^a   Rappert, Sugima ^a   Sun, Jibin ^a   Zeng, An Ping ^a  

^a HAMBURG UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Allosteric regulation; Aspartokinase; Molecular dynamics simulation; Statistical coupling analysis

Indexed keywords

ALLOSTERIC ENZYMES; ALLOSTERIC INHIBITION; ALLOSTERIC REGULATION; ALLOSTERY; AMINO ACID PRODUCTION; ASPARTOKINASE; CO-EVOLUTIONARY; COUPLING ANALYSIS; FEEDBACK-INSENSITIVE; INTERCONNECTED NETWORK; MOLECULAR DYNAMICS SIMULATION; PROTEIN DYNAMICS; PROTEIN MOTION; PROTEIN SEQUENCES; RANDOM MUTATION; STRAIN ENGINEERING; TARGET PREDICTION;

AMINO ACIDS; CATALYSTS; COMPUTER SIMULATION; DEREGULATION; ENZYME INHIBITION; ESCHERICHIA COLI; PROTEINS;

MOLECULAR DYNAMICS;

AMINO ACID; ASPARTATE KINASE; LYSINE; THREONINE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; DEREGULATION; ENZYME INHIBITION; ESCHERICHIA COLI; FEEDBACK SYSTEM; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MUTANT; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS;

ALLOSTERIC REGULATION; AMINO ACIDS; ASPARTATE KINASE; MOLECULAR DYNAMICS SIMULATION; PROTEIN STRUCTURE, SECONDARY;

ESCHERICHIA COLI;

EID: 79960434236     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2011.05.005     Document Type: Article

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