Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice

Nature Communications

Volumn 6, Issue , 2015, Pages

  Pai, Yun Jin ^a   Leung, Kit Yi ^a   Savery, Dawn ^a   Hutchin, Tim ^b   Prunty, Helen ^a   Heales, Simon ^a   Brosnan, Margaret E ^c   Brosnan, John T ^c   Copp, Andrew J ^a   Greene, Nicholas D E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; FORMIC ACID; GENOMIC DNA; GLYCINE CLEAVAGE SYSTEM; GLYCINE DEHYDROGENASE (DECARBOXYLATING); LIVER ENZYME; MESSENGER RNA; 5-BROMO-4-CHLORO-3-INDOLYL BETA-GALACTOSIDE; FORMIC ACID DERIVATIVE; GALACTOSIDE; GLYCINE; INDOLE DERIVATIVE; PRIMER DNA;

AMINO ACID; EMBRYO; ENZYME ACTIVITY; GENE EXPRESSION; GROWTH; METABOLISM; MUTATION; NEUROLOGY; RODENT;

ADULT; ALLELE; AMINO ACID BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CELL PROLIFERATION; CLINICAL FEATURE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROWN RUMP LENGTH; DECARBOXYLATION; DISEASE SEVERITY; DNA SEQUENCE; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME REPRESSION; FEMALE; GENOTYPE; GROWTH RETARDATION; HYDROCEPHALUS; HYPERGLYCINEMIA; INTRON; LETHALITY; MALE; MESSENGER RNA SYNTHESIS; MOUSE; NEURAL TUBE DEFECT; NEURULATION; NONHUMAN; NUCLEOTIDE METABOLISM; PERINATAL DEATH; PRIMARY PREVENTION; PROTEIN DEPLETION; PROTEIN EXPRESSION; RNA ANALYSIS; SEX DIFFERENCE; ANIMAL; DEFICIENCY; ENZYMOLOGY; GENETICS; HYPERGLYCINEMIA, NONKETOTIC; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MASS FRAGMENTOGRAPHY; METABOLISM; MOLECULAR GENETICS; NEURAL TUBE DEFECTS; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; FOLIC ACID; FORMATES; GALACTOSIDES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENOTYPE; GLYCINE; GLYCINE DEHYDROGENASE (DECARBOXYLATING); HYPERGLYCINEMIA, NONKETOTIC; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INDOLES; MICE; MOLECULAR SEQUENCE DATA; NEURAL TUBE DEFECTS; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 84924209564     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7388     Document Type: Article

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