Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos

Journal of Biological Chemistry

Volumn 285, Issue 7, 2010, Pages 4612-4620

  Pike, Schuyler T ^a,b   Rajendra, Rashmi ^a,c   Artzt, Karen ^a   Appling, Dean R ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; CYCLOHYDROLASE; CYTOPLASMIC PROCESS; EMBRYONIC FIBROBLASTS; EMBRYONIC TISSUE; GENE PRODUCTS; IN-SITU HYBRIDIZATION; MITOCHONDRIAL PATHWAYS; MONOFUNCTIONAL; MOUSE CELL LINES; MOUSE EMBRYOGENESIS; MOUSE EMBRYOS; ONE-CARBON UNITS; SPATIAL PATTERNS; STABLE-ISOTOPE LABELING; SYNTHASES; SYNTHETASES; TETRAHYDROFOLATES;

AMINO ACIDS; BIOCHEMISTRY; CELL CULTURE; COORDINATION REACTIONS; ENZYMES; HISTOLOGY; ISOTOPES; PHOSPHATASES;

MITOCHONDRIA;

CARBON; FORMIC ACID; GENE PRODUCT; GLYCINE; METHYL GROUP; MITOCHONDRIAL C1 TETRAHYDROFOLATE SYNTHASE; MONOFUNCTIONAL 10 FORMYL TETRAHYDROFOLATE SYNTHETASE; SYNTHETASE; UNCLASSIFIED DRUG; DEUTERIUM; FORMATE TETRAHYDROFOLATE LIGASE; FORMYL METHENYL METHYLENETETRAHYDROFOLATE SYNTHETASE; FORMYL-METHENYL-METHYLENETETRAHYDROFOLATE SYNTHETASE; HYDROLASE; METHIONINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MULTIENZYME COMPLEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; FIBROBLAST CULTURE; IN SITU HYBRIDIZATION; ISOTOPE LABELING; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; ANIMAL; ANIMAL EMBRYO; BIOLOGICAL MODEL; CELL LINE; GAS CHROMATOGRAPHY; GENETICS; IMMUNOBLOTTING; LIVER; MASS SPECTROMETRY; METABOLISM; MITOCHONDRION; MOUSE; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREGNANCY;

AMINOHYDROLASES; ANIMALS; BLOTTING, NORTHERN; CARBON; CELL LINE; CHROMATOGRAPHY, GAS; DEUTERIUM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EMBRYO, MAMMALIAN; FEMALE; FORMATE-TETRAHYDROFOLATE LIGASE; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; LIVER; MASS SPECTROMETRY; METHIONINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; PREGNANCY;

EID: 77951170478     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.079855     Document Type: Article

References (58)

1. Appling, D. R. (1991) FASEB J. 5, 2645-2651
2. Woeller, C. F., Anderson, D. D., Szebenyi, D. M., and Stover, P. J. (2007) J. Biol. Chem. 282, 17623-17631
3. Davis, S. R., Stacpoole, P. W., Williamson, J., Kick, L. S., Quinlivan, E. P., Coats, B. S., Shane, B., Bailey, L. B., and Gregory, J. F., 3rd (2004) Am. J. Physiol. Endocrinol. Metab. 286, E272-E279
4. Fu, T. F., Rife, J. P., and Schirch, V. (2001) Arch. Biochem. Biophys. 393, 42-50
5. Lamers, Y., Williamson, J., Theriaque, D. W., Shuster, J. J., Gilbert, L. R., Keeling, C., Stacpoole, P. W., and Gregory, J. F., 3rd (2009) J. Nutr. 139, 666-671
6. Barlowe, C. K., and Appling, D. R. (1988) Biofactors 1, 171-176
7. García-Martínez, L. F., and Appling, D. R. (1993) Biochemistry 32, 4671-4676
8. Barlowe, C. K., and Appling, D. R. (1990) Mol. Cell Biol. 10, 5679-5687
9. Pasternack, L. B., Laude, D. A., Jr., and Appling, D. R. (1994) Biochemistry 33, 74-82
10. Pasternack, L. B., Littlepage, L. E., Laude, D. A., Jr., and Appling, D. R. (1996) Arch. Biochem. Biophys. 326, 158-165
11. Kastanos, E. K., Woldman, Y. Y., and Appling, D. R. (1997) Biochemistry 36, 14956-14964
12. Gregory, J. F., 3rd, Cuskelly, G. J., Shane, B., Toth, J. P., Baumgartner, T. G., and Stacpoole, P. W. (2000) Am. J. Clin. Nutr. 72, 1535-1541
13. Herbig, K., Chiang, E. P., Lee, L. R., Hills, J., Shane, B., and Stover, P. J. (2002) J. Biol. Chem. 277, 38381-38389
14. Patel, H., Pietro, E. D., and MacKenzie, R. E. (2003) J. Biol. Chem. 278, 19436-19441
15. Quinlivan, E. P., Davis, S. R., Shelnutt, K. P., Henderson, G. N., Ghandour, H., Shane, B., Selhub, J., Bailey, L. B., Stacpoole, P. W., and Gregory, J. F., 3rd. (2005) J. Nutr. 135, 389-396
16. Anguera, M. C., Field, M. S., Perry, C., Ghandour, H., Chiang, E. P., Selhub, J., Shane, B., and Stover, P. J. (2006) J. Biol. Chem. 281, 18335-18342
17. MacFarlane, A. J., Liu, X., Perry, C. A., Flodby, P., Allen, R. H., Stabler, S. P., and Stover, P. J. (2008) J. Biol. Chem. 283, 25846-25853
18. Paukert, J. L., Williams, G. R., and Rabinowitz, J. C. (1977) Biochem. Biophys. Res. Comm. 77, 147-154
19. Schirch, L. (1978) Arch. Biochem. Biophys. 189, 283-290
20. Smith, G. K., Mueller, W. T., Wasserman, G. F., Taylor, W. D., and Benkovic, S. J. (1980) Biochemistry 19, 4313-4321
21. Hum, D. W., Bell, A. W., Rozen, R., and MacKenzie, R. E. (1988) J. Biol. Chem. 263, 15946-15950
22. Thigpen, A. E., West, M. G., and Appling, D. R. (1990) J. Biol. Chem. 265, 7907-7913
23. West, M. G., Horne, D. W., and Appling, D. R. (1996) Biochemistry 35, 3122-3132
24. Sies, H. (1982) in Metabolic Compartmentation (Sies, H., ed) pp. 205-231, Academic Press, New York
25. Veech, R. L. (1987) in Pyridine Nucleotide Coenzymes: Chemical, Biochemical, and Medical Aspects, Part B (Dolphin, D., Poulson, R., and Avramovic, O., eds) pp. 79-105, John Wiley & Sons, New York
26. Atkinson, D. E. (1977) Cellular Energy Metabolism and Its Regulation, Academic Press, New York
27. Howard, K. M., Muga, S. J., Zhang, L., Thigpen, A. E., and Appling, D. R. (2003) Gene 319, 85-97
28. Christensen, K. E., Patel, H., Kuzmanov, U., Mejia, N. R., and MacKenzie, R. E. (2005) J. Biol. Chem. 280, 7597-7602
29. MacFarlane, A. J., Perry, C. A., Girnary, H. H., Gao, D., Allen, R. H., Stabler, S. P., Shane, B., and Stover, P. J. (2009) J. Biol. Chem. 284, 1533-1539
30. Mejia, N. R., and MacKenzie, R. E. (1985) J. Biol. Chem. 260, 14616-14620
31. Mejia, N. R., Rios-Orlandi, E. M., and MacKenzie, R. E. (1986) J. Biol. Chem. 261, 9509-9513
32. Mejia, N. R., and MacKenzie, R. E. (1988) Biochem. Biophys. Res. Commun. 155, 1-6
33. Bélanger, C., and MacKenzie, R. E. (1989) J. Biol. Chem. 264, 4837-4843
34. Di Pietro, E., Sirois, J., Tremblay, M. L., and MacKenzie, R. E. (2002) Mol. Cell Biol. 22, 4158-4166
35. Di Pietro, E., Wang, X. L., and MacKenzie, R. E. (2004) Biochim. Biophys. Acta 1674, 78-84
36. Prasannan, P., Pike, S., Peng, K., Shane, B., and Appling, D. R. (2003) J. Biol. Chem. 278, 43178-43187
37. Walkup, A. S., and Appling, D. R. (2005) Arch. Biochem. Biophys. 442, 196-205
38. Prasannan, P., and Appling, D. R. (2009) Arch. Biochem. Biophys. 481, 86-93
39. Patel, H., Di Pietro, E., Mejia, N., and MacKenzie, R. E. (2005) Arch. Biochem. Biophys. 442, 133-139
40. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
41. Conlon, R. A., and Rossant, J. (1992) Development 116, 357-368
42. Vatankhah, M., and Moini, M. (1994) Biol. Mass Spectrometry 23, 277-282
43. Helgadóttir, S., Rosas-Sandoval, G., Söll, D., and Graham, D. E. (2007) J. Bacteriol. 189, 575-582
44. Storch, K. J., Wagner, D. A., Burke, J. F., and Young, V. R. (1988) Am. J. Physiol. 255, E322-E331
45. Bai, S., Ghoshal, K., Datta, J., Majumder, S., Yoon, S. O., and Jacob, S. T. (2005) Mol. Cell Biol. 25, 751-766
46. Kobayakawa, S., Miike, K., Nakao, M., and Abe, K. (2007) Genes Cells 12, 447-460
47. Horswill, M. A., Narayan, M., Warejcka, D. J., Cirillo, L. A., and Twining, S. S. (2008) Exp. Eye Res. 86, 586-600
48. Basch, M. L., García-Castro, M. I., and Bronner-Fraser, M. (2004) Birth Defects Res. C Embryo Today 72, 109-123
49. Huang, X., and Saint-Jeannet, J. P. (2004) Dev. Biol. 275, 1-11
50. Antony, A. C., and Hansen, D. K. (2000) Teratology 62, 42-50
51. Spiegelstein, O., Mitchell, L. E., Merriweather, M. Y., Wicker, N. J., Zhang, Q., Lammer, E. J., and Finnell, R. H. (2004) Dev. Dyn. 231, 221-231
52. Carter, M., Ulrich, S., Oofuji, Y., Williams, D. A., and Ross, M. E. (1999) Hum. Mol. Genet. 8, 2199-2204
53. Carter, M., Chen, X., Slowinska, B., Minnerath, S., Glickstein, S., Shi, L., Campagne, F., Weinstein, H., and Ross, M. E. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 12843-12848
54. Greene, N. D., and Copp, A. J. (2005) Am. J. Med. Genet. C Semin Med. Genet. 135C, 31-41
55. Parle-McDermott, A., Pangilinan, F., O'Brien, K. K., Mills, J. L., Magee, A. M., Troendle, J., Sutton, M., Scott, J. M., Kirke, P. N., Molloy, A. M., and Brody, L. C. (2009) Hum. Mutat. 30, 1650-1656
56. Chen, J., Giovannucci, E., Kelsey, K., Rimm, E. B., Stampfer, M. J., Colditz, G. A., Spiegelman, D., Willett, W. C., and Hunter, D. J. (1996) Cancer Res. 56, 4862-4864
57. Kawakami, K., Ruszkiewicz, A., Bennett, G., Moore, J., Watanabe, G., and Iacopetta, B. (2003) Clin. Cancer Res. 9, 5860-5865
58. Sugiura, T., Nagano, Y., Inoue, T., and Hirotani, K. (2004) Biochem. Biophys. Res. Commun. 315, 204-211