메뉴 건너뛰기




Volumn 130, Issue 4, 2007, Pages 1043-1049

Abnormal folate metabolism in foetuses affected by neural tube defects

Author keywords

Anencephaly; Folate; Neural tube defects; S adenosylhomocysteine; S adenosylmethionine; Spina bifida

Indexed keywords

DEOXYURIDINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; ANTIMETABOLITE; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; FOLIC ACID; METHIONINE SYNTHASE REDUCTASE;

EID: 34249690574     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awm028     Document Type: Article
Times cited : (51)

References (33)
  • 2
    • 84881328597 scopus 로고    scopus 로고
    • The cytogenetics of pregnancy
    • Rooney DE, editor, 3rd edn. Oxford: Oxford University Press;
    • Boyle T, Griffin D. The cytogenetics of pregnancy. In: Rooney DE, editor. Human cytogenetics: constitutional analysis. 3rd edn. Oxford: Oxford University Press; 2001.
    • (2001) Human cytogenetics: Constitutional analysis
    • Boyle, T.1    Griffin, D.2
  • 4
    • 18644379774 scopus 로고    scopus 로고
    • A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: Report of the Birth Defects Research Group
    • Brody LC, Conley M, Cox C, Kirke PN, McKeever MP, Mills JL, et al. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. Am J Hum Genet 2002; 71: 1207-15.
    • (2002) Am J Hum Genet , vol.71 , pp. 1207-1215
    • Brody, L.C.1    Conley, M.2    Cox, C.3    Kirke, P.N.4    McKeever, M.P.5    Mills, J.L.6
  • 5
    • 33845977697 scopus 로고    scopus 로고
    • Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry
    • Burren KA, Mills K, Copp AJ, Greene ND. Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2006; 844: 112-8.
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.844 , pp. 112-118
    • Burren, K.A.1    Mills, K.2    Copp, A.J.3    Greene, N.D.4
  • 6
    • 0035172715 scopus 로고    scopus 로고
    • Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine betasynthase heterozygous mice
    • Caudill MA, Wang JC, Melnyk S, Pogribny IP, Jernigan S, Collins MD, et al. Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine betasynthase heterozygous mice. J Nutr 2001; 131: 2811-8.
    • (2001) J Nutr , vol.131 , pp. 2811-2818
    • Caudill, M.A.1    Wang, J.C.2    Melnyk, S.3    Pogribny, I.P.4    Jernigan, S.5    Collins, M.D.6
  • 8
    • 0027080461 scopus 로고
    • Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation
    • Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327: 1832-5.
    • (1992) N Engl J Med , vol.327 , pp. 1832-1835
    • Czeizel, A.E.1    Dudás, I.2
  • 9
    • 33646196192 scopus 로고    scopus 로고
    • Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos
    • Dunlevy LPE, Burren KA, Chitty LS, Copp AJ, Greene NDE. Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos. FEBS Lett 2006a; 580: 2803-7.
    • (2006) FEBS Lett , vol.580 , pp. 2803-2807
    • Dunlevy, L.P.E.1    Burren, K.A.2    Chitty, L.S.3    Copp, A.J.4    Greene, N.D.E.5
  • 10
    • 33748433110 scopus 로고    scopus 로고
    • Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res A Clin Mol
    • Dunlevy LPE, Burren KA, Mills K, Chitty LS, Copp AJ, Greene NDE. Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res A Clin Mol Teratol 2006b; 76: 544-52.
    • (2006) Teratol , vol.76 , pp. 544-552
    • Dunlevy, L.P.E.1    Burren, K.A.2    Mills, K.3    Chitty, L.S.4    Copp, A.J.5    Greene, N.D.E.6
  • 11
    • 0032568871 scopus 로고    scopus 로고
    • Embryonic folate metabolism and mouse neural tube defects
    • Fleming A, Copp AJ. Embryonic folate metabolism and mouse neural tube defects. Science 1998; 280: 2107-9.
    • (1998) Science , vol.280 , pp. 2107-2109
    • Fleming, A.1    Copp, A.J.2
  • 12
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 13
    • 0037865225 scopus 로고    scopus 로고
    • Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans
    • Gueant-Rodriguez RM, Rendeli C, Namour B, Venuti L, Romanov A, Anello G, et al. Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans. Neurosci Lett 2003; 344: 189-92.
    • (2003) Neurosci Lett , vol.344 , pp. 189-192
    • Gueant-Rodriguez, R.M.1    Rendeli, C.2    Namour, B.3    Venuti, L.4    Romanov, A.5    Anello, G.6
  • 14
    • 0027521009 scopus 로고
    • Uptake and utilization of DL-5-[methyl-14C] tetrahydropteroylmonoglutamate by cultured cytotrophoblasts associated with neural tube defects
    • Habibzadeh N, Schorah CJ, Seller MJ, Smithells RW, Levene MI. Uptake and utilization of DL-5-[methyl-14C] tetrahydropteroylmonoglutamate by cultured cytotrophoblasts associated with neural tube defects. Proc Soc Exp Biol Med 1993; 203: 45-54.
    • (1993) Proc Soc Exp Biol Med , vol.203 , pp. 45-54
    • Habibzadeh, N.1    Schorah, C.J.2    Seller, M.J.3    Smithells, R.W.4    Levene, M.I.5
  • 15
    • 0942290719 scopus 로고    scopus 로고
    • New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): A risk factor for spina bifida acting in mothers during pregnancy?
    • Johnson WG, Stenroos ES, Spychala JR, Chatkupt S, Ming SX, Buyske S. New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? Am J Med Genet 2004; 124A: 339-45.
    • (2004) Am J Med Genet , vol.124 A , pp. 339-345
    • Johnson, W.G.1    Stenroos, E.S.2    Spychala, J.R.3    Chatkupt, S.4    Ming, S.X.5    Buyske, S.6
  • 16
    • 0001650638 scopus 로고
    • Effect of deoxyuridine on incorporation of tritiated thymidine: Difference between normoblasts and megaloblasts
    • Killman S-A. Effect of deoxyuridine on incorporation of tritiated thymidine: difference between normoblasts and megaloblasts. Acta Med Scand 1964; 175: 483-8.
    • (1964) Acta Med Scand , vol.175 , pp. 483-488
    • Killman, S.-A.1
  • 17
    • 3042784787 scopus 로고    scopus 로고
    • Impact of the MTHFR C677T polymorphism on risk of neural tube defects: Case-control study
    • Kirke PN, Mills JL, Molloy AM, Brody LC, O'Leary VB, Daly L, et al. Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study. Br Med J 2004; 328: 1535-6.
    • (2004) Br Med J , vol.328 , pp. 1535-1536
    • Kirke, P.N.1    Mills, J.L.2    Molloy, A.M.3    Brody, L.C.4    O'Leary, V.B.5    Daly, L.6
  • 19
    • 0033808685 scopus 로고    scopus 로고
    • Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes
    • Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 2000; 71: 121-38.
    • (2000) Mol Genet Metab , vol.71 , pp. 121-138
    • Lucock, M.1
  • 20
    • 0031769901 scopus 로고    scopus 로고
    • Impaired regeneration of monoglutamyl tetrahydrofolate leads to cellular folate depletion in mothers affected by a spina bifida pregnancy
    • Lucock MD, Daskalakis I, Lumb CH, Schorah CJ, Levene MI. Impaired regeneration of monoglutamyl tetrahydrofolate leads to cellular folate depletion in mothers affected by a spina bifida pregnancy. Mol Genet Metab 1998; 65: 18-30.
    • (1998) Mol Genet Metab , vol.65 , pp. 18-30
    • Lucock, M.D.1    Daskalakis, I.2    Lumb, C.H.3    Schorah, C.J.4    Levene, M.I.5
  • 21
    • 0031170999 scopus 로고    scopus 로고
    • Risk of neural tube defect-affected pregnancy is associated with a block in maternal one-carbon metabolism at the level of N-5-methyltetrahydrofolate: Homocysteine methyltransferase
    • Lucock MD, Wild J, Lumb CH, Oliver M, Kendall R, Daskalakis I, et al. Risk of neural tube defect-affected pregnancy is associated with a block in maternal one-carbon metabolism at the level of N-5-methyltetrahydrofolate: homocysteine methyltransferase. Biochem Mol Med 1997; 61: 28-40.
    • (1997) Biochem Mol Med , vol.61 , pp. 28-40
    • Lucock, M.D.1    Wild, J.2    Lumb, C.H.3    Oliver, M.4    Kendall, R.5    Daskalakis, I.6
  • 24
    • 0030018760 scopus 로고    scopus 로고
    • 5,10 methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects
    • Ou CY, Stevenson RE, Brown VK, Schwartz CE, Allen WP, Khoury MJ, et al. 5,10 methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. Am J Med Genet 1996; 63: 610-4.
    • (1996) Am J Med Genet , vol.63 , pp. 610-614
    • Ou, C.Y.1    Stevenson, R.E.2    Brown, V.K.3    Schwartz, C.E.4    Allen, W.P.5    Khoury, M.J.6
  • 25
    • 0041385695 scopus 로고    scopus 로고
    • Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida
    • Pietrzyk JJ, Bik-Multanowski M, Sanak M, Twardowska M. Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida. J Appl Genet 2003; 44: 111-3.
    • (2003) J Appl Genet , vol.44 , pp. 111-113
    • Pietrzyk, J.J.1    Bik-Multanowski, M.2    Sanak, M.3    Twardowska, M.4
  • 26
    • 0032589204 scopus 로고    scopus 로고
    • Folate and vitamin B12
    • Scott JM. Folate and vitamin B12. Proc Nutr Soc 1999; 58: 441-8.
    • (1999) Proc Nutr Soc , vol.58 , pp. 441-448
    • Scott, J.M.1
  • 28
    • 0031971515 scopus 로고    scopus 로고
    • A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects
    • Van der Put NMJ, Gabreëls F, Stevens EMB, Smeitink JA, Trijbels FJ, Eskes TK, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects. Am J Hum Genet 1998; 62: 1044-51.
    • (1998) Am J Hum Genet , vol.62 , pp. 1044-1051
    • Van der Put, N.M.J.1    Gabreëls, F.2    Stevens, E.M.B.3    Smeitink, J.A.4    Trijbels, F.J.5    Eskes, T.K.6
  • 30
    • 0037158488 scopus 로고    scopus 로고
    • Studies with His475Tyr glutamate carboxipeptidase II polymorphism and neural tube defects
    • Vieira AR, Trembath D, Vandyke DC, Murray JC, Marker S, Lerner G, et al. Studies with His475Tyr glutamate carboxipeptidase II polymorphism and neural tube defects. Am J Med Genet 2002; 111: 218-9.
    • (2002) Am J Med Genet , vol.111 , pp. 218-219
    • Vieira, A.R.1    Trembath, D.2    Vandyke, D.C.3    Murray, J.C.4    Marker, S.5    Lerner, G.6
  • 31
    • 0025863475 scopus 로고    scopus 로고
    • Wald N, Sneddon J, Densem J, Frost C, Stone R. MRC Vitamin Study Res Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338: 131-7.
    • Wald N, Sneddon J, Densem J, Frost C, Stone R. MRC Vitamin Study Res Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338: 131-7.
  • 32
    • 0032856882 scopus 로고    scopus 로고
    • A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida
    • Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, et al. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab 1999; 67: 317-23.
    • (1999) Mol Genet Metab , vol.67 , pp. 317-323
    • Wilson, A.1    Platt, R.2    Wu, Q.3    Leclerc, D.4    Christensen, B.5    Yang, H.6
  • 33
    • 0037341890 scopus 로고    scopus 로고
    • Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects
    • Zhu H, Wicker NJ, Shaw GM, Lammer EJ, Hendricks K, Suarez L, et al. Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Mol Genet Metab 2003; 78: 216-21.
    • (2003) Mol Genet Metab , vol.78 , pp. 216-221
    • Zhu, H.1    Wicker, N.J.2    Shaw, G.M.3    Lammer, E.J.4    Hendricks, K.5    Suarez, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.