Production of 1-carbon units from glycine is extensive in healthy men and women 1,2

Journal of Nutrition

Volumn 139, Issue 4, 2009, Pages 666-671

  Lamers, Yvonne ^a   Williamson, Jerry ^a   Theriaque, Douglas W ^b   Shuster, Jonathan J ^b,c   Gilbert, Lesa R ^d   Keeling, Christine ^d   Stacpoole, Peter W ^b,d,e   Gregory, Jesse F ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b General Clinical Research Center   (United States)

^c Department of Epidemiology and Health Policy Research ^*

^d Division of Endocrinology and Metabolism   (United States)

^e UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CARBON 13; CARBON DIOXIDE; GLYCINE; GLYCINE CLEAVAGE SYSTEM; LEUCINE; METHYLENETETRAHYDROFOLIC ACID;

ADULT; ARTICLE; CARBON METABOLISM; CATABOLISM; CONTROLLED STUDY; DECARBOXYLATION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; BODY WEIGHT; HEALTH; METABOLISM;

ADULT; BODY WEIGHT; CARBON; CARBON DIOXIDE; FEMALE; GLYCINE; HEALTH; HUMANS; MALE;

EID: 64049109319     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.103580     Document Type: Article

References (27)

1. Kikuchi G. The glycine cleavage system: composition, reaction mechanism, and physiological significance. Mol Cell Biochem. 1973;1:169-87.
2. Bailey LB, Gregory JF III. Folate metabolism and requirements. J Nutr. 1999;129:779-82.
3. Garcia-Martinez LF, Appling DR. Characterization of the folate- dependent mitochondrial oxidation of carbon 3 of serine. Biochemistry. 1993;32:4671-6.
4. 3]leucine. J Nutr. 2007;137:2647-52.
5. Cuskelly GJ, Stacpoole PW, Williamson J, Baumgartner TG, Gregory JF III. Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kinetics. Am J Physiol Endocrinol Metab. 2001;281:E1182-90.
6. Davis SR, Stacpoole PW, Williamson J, Kick LS, Quinlivan EP, Coats BS, Shane B, Bailey LB, Gregory JF III. Tracer-derived total and folate- dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am J Physiol Endocrinol Metab. 2004;286:E272-9. Erratum in Am J Physiol Endo- crinol Metab 2004;286:E674.
7. Lamers Y, Williamson J, Ralat M, Quinlivan EP, Gilbert LR, Keeling C, Stevens RD, Newgard CB, Ueland PM, et al. Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women. J Nutr. 2009;139:452-60.
8. Parra MD, Martinez JA. Nutritional aspects of breath testing based on stable isotopes. Nutr Rev. 2006;64:338-47.
9. Ubbink JB, Serfontein WJ, de Villiers LS. Stability of pyridoxal-5- phosphate semicarbazone: applications in plasma vitamin B6 analysis and population surveys of vitamin B6 nutritional status. J Chromatogr.1985;342:277- 84.
10. Pfeiffer CM, Huff DL, Gunter EW. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin Chem. 1999;45:290-2.
11. 13C]methi-onine. Am J Physiol. 1988;255:E322-31.
12. MacCoss MJ, Fukagawa NK, Matthews DE. Measurement of intracel- lular sulfur amino acid metabolism in humans. Am J Physiol Endocrinol Metab. 2001;280:E947-55.
13. Wolfe RR. Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis. New York: Wiley Liss; 1992.
14. Davis SR, Scheer JB, Quinlivan EP, Coats BS, Stacpoole PW, Gregory JF III. Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men. Am J Clin Nutr. 2005;81:648-55.
15. 3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolism. Am J Clin Nutr. 2000;72:1535-41.
16. 15N] glycine for measurement of fractional synthetic rates of apolipo- protein B of very-low-density lipoprotein. Metabolism. 1995;44:1253-8.
17. Cryer DR, Matsushima T, Marsh JB, Yudkoff M, Coates PM, Cortner JA. Direct measurement of apolipoprotein B synthesis in human very low density lipoprotein using stable isotopes and mass spectrometry. J Lipid Res. 1986;27:508-16.
18. Robert JJ, Bier DM, Zhao XH, Matthews DE, Young VR. Glucose and insulin effects on the novo amino acid synthesis in young men: studies with stable isotope labeled alanine, glycine, leucine, and lysine. Metabolism. 1982;31:1210-8.
19. Hiraga K, Kochi H, Hayasaka K, Kikuchi G, Nyhan WL. Defective glycine cleavage system in nonketotic hyperglycinemia. Occurrence of a less active glycine decarboxylase and an abnormal aminomethyl carrier protein. J Clin Invest. 1981;68:525-34.
20. Pearl PL, Capp PK, Novotny EJ, Gibson KM. Inherited disorders of neurotransmitters in children and adults. Clin Biochem. 2005;38:1051-8.
21. Xue HH, Sakaguchi T, Fujie M, Ogawa H, Ichiyama A. Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/ alanine:glyoxylate aminotransferase. J Biol Chem. 1999;274:16028-33.
22. Nijhout HF, Reed MC, Lam SL, Shane B, Gregory JF III, Ulrich CM. In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor Biol Med Model. 2006;3:40.
23. Krupenko SA, Oleinik NV. 10-Formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells. Cell Growth Differ. 2002;13:227-36.
24. Van Hove JL, Lazeyras F, Zeisel SH, Bottiglieri T, Hyland K, Charles HC, Gray L, Jaeken J, Kahler SG. One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. J Inherit Metab Dis. 1998;21:799-811.
25. Gersovitz M, Bier D, Matthews D, Udall J, Munro HN, Young VR. Dynamic aspects of whole body glycine metabolism: influence of protein intake in young adult and elderly males. Metabolism. 1980;29:1087-94.
26. Jois M, Hall B, Brosnan JT. Stimulation of glycine catabolism in isolated perfused rat liver by calcium mobilizing hormones and in isolated rat liver mitochondria by submicromolar concentrations of calcium. J Biol Chem. 1990;265:1246-8.
27. Jois M, Hall B, Fewer K, Brosnan JT. Regulation of hepatic glycine catabolism by glucagon. J Biol Chem. 1989;264:3347-51.