Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain

Molecular and Cellular Biochemistry

Volumn 378, Issue 1-2, 2013, Pages 229-236

  Leung, Kit Yi ^a   De Castro, Sandra C P ^a   Cabreiro, Filipe ^b   Gustavsson, Peter ^c   Copp, Andrew J ^a   Greene, Nicholas D E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Bacteria; Embryo; Folate; Liquid chromatography tandem mass spectrometry; Methotrexate

Indexed keywords

FOLIC ACID; METHOTREXATE; TETRAHYDROFOLIC ACID DERIVATIVE;

ANIMAL; ARTICLE; BRAIN; C57BL MOUSE; CBA MOUSE; CELL LINE; CHEMISTRY; ESCHERICHIA COLI; HUMAN; METABOLISM; METHODOLOGY; MOUSE; PRENATAL DEVELOPMENT; SPECIES DIFFERENCE; STANDARD; TANDEM MASS SPECTROMETRY;

ANIMALS; BRAIN; CELL LINE; ESCHERICHIA COLI; FOLIC ACID; HUMANS; METHOTREXATE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; REFERENCE STANDARDS; SPECIES SPECIFICITY; TANDEM MASS SPECTROMETRY; TETRAHYDROFOLATES;

EID: 84886785031     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1613-y     Document Type: Article

References (33)

1. Stover PJ (2009) One-carbon metabolism-genome interactions in folate-associated pathologies. J Nutr 139:2402-2405
2. Tibbetts AS, Appling DR (2010) Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr 30:57-81
3. Blom HJ, Smulders Y (2011) Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J Inherit Metab Dis 34:75-81
4. Zhao R, Diop-Bove N, Visentin M, Goldman ID (2011) Mechanisms of membrane transport of folates into cells and across epithelia. Annu Rev Nutr 31:177-201
5. Gelineau-van WJ, Heller S, Bauer LK, Wilberding J, Maddox JR, Aleman F, Rosenquist TH, Finnell RH (2008) Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation. Birth Defects Res A Clin Mol Teratol 82:494-507
6. Piedrahita JA, Oetama B, Bennett GD, Van Waes J, Kamen BA, Richardson J, Lacey SW, Anderson RGW, Finnell RH (1999) Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Nat Genet 23:228-232
7. Zhao RB, Russell RG, Wang YH, Liu LB, Gao F, Kneitz B, Edelmann W, Goldman ID (2001) Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs. J Biol Chem 276:10224-10228
8. Giovannucci E (2002) Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr 132:2350S-2355S
9. Blom HJ, Shaw GM, Den Heijer M, Finnell RH (2006) Neural tube defects and folate: case far from closed. Nat Rev Neurosci 7:724-731
10. Kim YI (2006) Folate: a magic bullet or a double edged sword for colorectal cancer prevention? Gut 55:1387-1389
11. Wernimont SM, Clark AG, Stover PJ, Wells MT, Litonjua AA, Weiss ST, Gaziano JM, Vokonas PS, Tucker KL, Cassano PA (2012) Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. J Nutr 142:1272-1279
12. Fleming A, Copp AJ (1998) Embryonic folate metabolism and mouse neural tube defects. Science 280:2107-2109
13. Dunlevy LPE, Chitty LS, Doudney K, Burren KA, Stojilkovic-Mikic T, Stanier P, Scott R, Copp AJ, Greene NDE (2007) Abnormal folate metabolism in foetuses affected by neural tube defects. Brain 130:1043-1049
14. Beaudin AE, Abarinov EV, Noden DM, Perry CA, Chu S, Stabler SP, Allen RH, Stover PJ (2011) Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr 93:789-798
15. Ulrich CM, Potter JD (2006) Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev 15:189-193
16. Kim YI (2006) Does a high folate intake increase the risk of breast cancer? Nutr Rev 64:468-475
17. Greene ND, Stanier P, Moore GE (2011) The emerging role of epigenetic mechanisms in the etiology of neural tube defects. Epigenetics 6:875-883
18. Ulrich CM, Reed MC, Nijhout HF (2008) Modeling folate, onecarbon metabolism, and DNA methylation. Nutr Rev 66(Suppl 1):S27-S30
19. Neuhouser ML, Nijhout HF, Gregory JF III, Reed MC, James SJ, Liu A, Shane B, Ulrich CM (2011) Mathematical modeling predicts the effect of folate deficiency and excess on cancerrelated biomarkers. Cancer Epidemiol Biomarkers Prev 20: 1912-1917
20. Burren KA, Mills K, Copp AJ, Greene NDE (2006) Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 84:4112-4118
21. Dunlevy LPE, Burren KA, Chitty LS, Copp AJ, Greene NDE (2006) Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos. FEBS Lett 580: 2803-2807
22. Timmons L, Court DL, Fire A (2001) Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263:103-112
23. Toepoel M, Steegers-Theunissen RP, Ouborg NJ, Franke B, Ladd AM, Joosten PH, van Zoelen EJ (2009) Interaction of PDGFRA promoter haplotypes and maternal environmental exposures in the risk of spina bifida. Birth Defects Res A Clin Mol Teratol 85:629-636
24. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94
25. Gustavsson P, Greene ND, Lad D, Pauws E, de Castro SC, Stanier P, Copp AJ (2007) Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model. Hum Mol Genet 16:2640-2646
26. Garratt LC, Ortori CA, Tucker GA, Sablitzky F, Bennett MJ, Barrett DA (2005) Comprehensive metabolic profiling of monoand polyglutamated folates and their precursors in plant and animal tissue using liquid chromatography/negative ion electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom 19:2390-2398
27. Reed MC, Nijhout HF, Neuhouser ML, Gregory JF III, Shane B, James SJ, Boynton A, Ulrich CM (2006) A mathematical model gives insights into nutritional and genetic aspects of folatemediated one-carbon metabolism. J Nutr 136:2653-2661
28. Ulrich CM, Neuhouser M, Liu AY, Boynton A, Gregory JF III, Shane B, James SJ, Reed MC, Nijhout HF (2008) Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev 17:1822-1831
29. Banka S, Blom HJ, Walter J, Aziz M, Urquhart J, Clouthier CM, Rice GI, de Brouwer AP, Hilton E, Vassallo G, Will A, Smith DE, Smulders YM, Wevers RA, Steinfeld R, Heales S, Crow YJ, Pelletier JN, Jones S, Newman WG (2011) Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency. Am J Hum Genet 88:216-225
30. Rakic P (1972) Mode of cell migration to the superficial layers of fetal monkey neocortex. J Comp Neurol 14:561-583
31. Stover PJ, Field MS (2011) Trafficking of intracellular folates. Adv Nutr 2:325-331
32. Kure S, Kato K, Dinopoulos A, Gail C, DeGrauw TJ, Christodoulou J, Bzduch V, Kalmanchey R, Fekete G, Trojovsky A, Plecko B, Breningstall G, Tohyama J, Aoki Y, Matsubara Y (2006) Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia. Hum Mutat 27:343-352
33. Narisawa A, Komatsuzaki S, Kikuchi A, Niihori T, Aoki Y, Fujiwara K, Tanemura M, Hata A, Suzuki Y, Relton CL, Grinham J, Leung KY, Partridge D, Robinson A, Stone V, Gustavsson P, Stanier P, Copp AJ, Greene ND, Tominaga T, Matsubara Y, Kure S (2012) Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum Mol Genet 21:1496-1503