Gene-environment interactions in the causation of neural tube defects: Folate deficiency increases susceptibility conferred by loss of Pax3 function

Human Molecular Genetics

Volumn 17, Issue 23, 2008, Pages 3675-3685

  Burren, Katie A ^a   Savery, Dawn ^a   Massa, Valentina ^a   Kok, Robert M ^b   Scott, John M ^c   Blom, Henk J ^b   Copp, Andrew J ^a   Greene, Nicholas D E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FOLIC ACID; HOMOCYSTEINE; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR PAX3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DIET RESTRICTION; DNA METHYLATION; EMBRYO; ENVIRONMENTAL FACTOR; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HEREDITY; HYPERHOMOCYSTEINEMIA; INTRAUTERINE GROWTH RETARDATION; MALE; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; PATHOGENESIS; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEIN CONTENT; SEX DIFFERENCE; VITAMIN SUPPLEMENTATION; WILD TYPE;

ANIMALS; DISEASE SUSCEPTIBILITY; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; HUMANS; MALE; METHYLATION; MICE; MICE, TRANSGENIC; MUTATION; NEURAL TUBE DEFECTS; PAIRED BOX TRANSCRIPTION FACTORS;

MUS;

EID: 56049094808     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddn262     Document Type: Article

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