Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant dravet syndrome model during development

Neurobiology of Disease

Volumn 77, Issue , 2015, Pages 35-48

  Tsai, Ming Shian ^a   Lee, Meng Larn ^b   Chang, Chun Yun ^c   Fan, Hsiang Hsuan ^a   Yu, I Shing ^a   Chen, You Tzung ^a   You, Jhih Yi ^a   Chen, Chun Yu ^a   Chang, Fang Chia ^b   Hsiao, Jane H ^d   Khorkova, Olga ^d   Liou, Horng Huei ^a   Yanagawa, Yuchio ^e   Lee, Li Jen ^a   Lin, Shu Wha ^a,b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d OPKO Health Inc   (United States)

^e GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Dravet syndrome; Epilepsy; Mouse model; SCN1A

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; GLUTAMIC ACID; MUTANT PROTEIN; SODIUM CHANNEL NAV1.1; 4 AMINOBUTYRIC ACID; BIOCYTIN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 1; LYSINE; SCN1A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; DENTATE GYRUS; DEVELOPMENTAL DISORDER; DISEASE PREDISPOSITION; FEMALE; FUNCTIONAL DISEASE; GENETIC DISORDER; GRANULE CELL; HIPPOCAMPUS; HYPERTHERMIA; MALE; MOUSE; NERVE CELL EXCITABILITY; NERVE POTENTIAL; NEUROTRANSMISSION; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SPONTANEOUS SEIZURE; STRUCTURAL DEFICIT; ACTION POTENTIAL; ADVERSE EFFECTS; AGE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; DISEASE MODEL; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HYPERTHERMIC THERAPY; IN VITRO STUDY; METABOLISM; MUTATION; MYOCLONUS EPILEPSY; NERVE CELL; NERVE CELL NETWORK; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; SEIZURES; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ACTION POTENTIALS; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; DENTATE GYRUS; DISEASE MODELS, ANIMAL; EPILEPSIES, MYOCLONIC; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HYPERTHERMIA, INDUCED; IN VITRO TECHNIQUES; LYSINE; MALE; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; MUTATION; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; NERVE NET; NEURONS; SEIZURES;

EID: 84924129405     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.02.010     Document Type: Article

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