Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures

Neurobiology of Disease

Volumn 41, Issue 2, 2011, Pages 261-269

  Ohno, Yukihiro ^a   Ishihara, Shizuka ^a   Mashimo, Tomoji ^b   Sofue, Nobumasa ^a   Shimizu, Saki ^a   Imaoku, Takuji ^a   Tsurumi, Toshiko ^b   Sasa, Masashi ^c   Serikawa, Tadao ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Nagisa Clinic   (Japan)

Author keywords

Febrile seizure; Missense mutation; Na v1.1 channel; Rat model; Scn1a

Indexed keywords

DIAZEPAM; ETHOSUXIMIDE; PHENYTOIN; PROTEIN FOS; SODIUM CHANNEL NAV1.1; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EPILEPTIC DISCHARGE; EXCITABILITY; FEBRILE CONVULSION; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; HYPERTHERMIA; IMMUNOREACTIVITY; IN VIVO STUDY; LIMBIC SYSTEM; MALE; MISSENSE MUTATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; DISEASE MODELS, ANIMAL; FEVER; GENETIC PREDISPOSITION TO DISEASE; LIMBIC SYSTEM; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; RATS; RATS, INBRED F344; RATS, MUTANT STRAINS; RATS, TRANSGENIC; SEIZURES, FEBRILE; SODIUM CHANNELS;

EID: 78650599715     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.09.013     Document Type: Article

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