Comparative pharmacokinetics of puerarin, daidzin, baicalin, glycyrrhizic acid, liquiritin, berberine, palmatine and jateorhizine by liquid chromatography-mass spectrometry after oral administration of Gegenqinlian decoction and active components alignment (ACA) to rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 988, Issue , 2015, Pages 33-44

  Xu, Beilei ^a   Li, Pengyue ^b   Zhang, Guijun ^c  

^a HARBIN UNIVERSITY OF COMMERCE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Active components alignment (ACA); Gegenqinlian decoction (GQD); LC MS MS; Pharmacokinetics; Puerarin

Indexed keywords

ALIGNMENT; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; FLAVONOIDS; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORGANIC COMPOUNDS; PHARMACOKINETICS;

ACTIVE COMPONENTS; CONCENTRATION RANGES; GEGENQINLIAN DECOCTION (GQD); LC-MS/MS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; PUERARIN; SELECTED REACTION MONITORING; SIMULTANEOUS ANALYSIS;

DRUG PRODUCTS;

ACETIC ACID; ACETONITRILE; ALKALOID; AMMONIUM ACETATE; BAICALIN; BERBERINE; CHINESE DRUG; DAIDZIN; GEGENQINLIAN; GLYCYRRHIZIC ACID; HESPERIDIN; JATEORHIZINE; LIQUIRITIN; PALMATINE; PUERARIN; UNCLASSIFIED DRUG; FLAVONOID; HERBACEOUS AGENT;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BIOTECHNOLOGY; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY; ELUTION; EXTRACTION; IONIZATION; LIMIT OF DETECTION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MEASUREMENT ACCURACY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; CHEMISTRY; LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL; TANDEM MASS SPECTROMETRY;

RATTUS;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; DRUGS, CHINESE HERBAL; FLAVONOIDS; GLYCYRRHIZIC ACID; LIMIT OF DETECTION; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84924104763     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.01.039     Document Type: Article

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