Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 863, Issue 2, 2008, Pages 195-205

  Deng, Yating ^a,b   Liao, Qiongfeng ^c   Li, Suhua ^a   Bi, Kaishun ^b   Pan, Biyan ^a   Xie, Zhiyong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Berberine; Coptis evodia herb couple; Jatrorrhizine; LC MS MS; Palmatine; Pharmacokinetics

Indexed keywords

ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; PLANTS (BOTANY); PROTEINS;

RAT PLASMA; SELECTED REACTION MONITORING (SRM); TANDEM MASS SPECTROMETRY;

LIQUID CHROMATOGRAPHY;

BERBERINE; COPTIS RHIZOME; EVODIA FRUIT; JATRORRHIZINE; PALMATINE; TETRAHYDROPALMATINE;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); COPTIS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; ELECTROSPRAY; ENTEROHEPATIC CIRCULATION; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ANIMALS; BERBERINE; BERBERINE ALKALOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPTIS; DRUGS, CHINESE HERBAL; EVODIA; MALE; MOLECULAR STRUCTURE; PLANT PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

COPTIS; EVODIA; RATTUS;

EID: 39749152708     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.12.028     Document Type: Article

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