Comparative pharmacokinetics of berberine, palmatine and jatrorrhizine in rat plasma after oral administration of Rhizoma coptidis and Zuojinwan using liquid chromatography-tandem mass spectrometry

Iranian Journal of Pharmaceutical Research

Volumn 11, Issue 3, 2012, Pages 949-957

  Yan, Rui ^a   Wang, Yin ^a   Liu, Youping ^a   Di, Xin ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Liquid chromatography tandem mass spectrometry; Pharmacokinetics; Rhizoma coptidis; Zuojinwan preparation

Indexed keywords

ACETONITRILE; BERBERINE; CHINESE DRUG; COPTIS RHIZOME EXTRACT; FORMIC ACID; JATRORRHIZINE; METHANOL; METRONIDAZOLE; PALMATINE; UNCLASSIFIED DRUG; WATER; ZUOJINWAN;

ACCURACY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; MONITORING; PROCESS DESIGN; SELECTED REACTION MONITORING; TANDEM MASS SPECTROMETRY;

EID: 84865197570     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Tanaka T, Metori K, Mineo S, Hirotani M, Furuya T, Matsumoto H, Satoh T and Kobayashi S. Studies on collagenase inhibitors. IV. Inhibitors of bacterial collagenase in Coptidis rhizome. Yakugaku Zasshi (1991) 111: 538-541.
2. Bova S, Padrini R, Goldman WF, Berman DM and Cargnelli G. On the mechanism of vasodilating action of berberine: possible role of inositol lipid signaling system. J. Pharmacol. Exp. Ther. (1992) 261: 318-323.
3. Chiou WF, Yen MH and Chen CF. Mechanism of vasodilatory effect of berberine in rat mesenteric artery. Eur. J. Pharmacol. (1991) 204: 35-40.
4. Lu YX, Lin XY and Lu ZY. Chemical constituents of Evodia rutaecarpa and its clinical application. Pharm. J. Chin. PLA (2002) 18: 218-220.
5. Zhou LD and Li JC. Reviews of pharmacology studies on Evodia rutaecarpa Chin. Arch. Tra. Chin. Med. (2005) 23: 159-160.
6. Lu T, Liang Y, Song J, Xie L, Wang GJ and Liu XD. Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method. J. Pharmaceut. Biomed. (2006) 40: 1218-1224.
7. Deng YT, Liao QF, Li SH, Bi KS, Pan BY and Xie ZY. Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple. J. Chromatogr. B (2008) 863: 195-205.
8. Zuo F, Nakamura N, Akao T and Hattori M. Pharmacokinetics of berberine and its main metabolites in conventional and Pseudo germ-free rats determined by liquid chromatography/Ion trap mass spectrometry. Drug Metab. Dispos. (2006) 34: 2064-2072.
9. Yu S, Pang XY, Deng YX, Liu L, Liang Y, Liu XD, Xie L, Wang GJ and Wang XT. A sensitive and specific liquid chromatography mass spectrometry method for simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma. Int. J. Mass Spectrom. (2007) 268: 30-37.
10. Huang J, Wang G, Jin Y, Shen T and Weng W. Determination of palmatine in canine plasma by liquid chromatography-tandem mass spectrometry with solid-phase extraction. J. Chromatogr. B (2007) 854: 279-285.
11. Feng J, Xu W, Tao X, Wei H, Cai F, Jiang B and Chen WS. Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. J. Pharm. Biomed. Anal. (2010) 53: 591-598.
12. Wang W, Li CY, Wen XD, Li P and Qi LW. Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics. J. Chromatogr. B (2009) 877: 671-697.
13. Yang Z, Zhu W, Gao S, Xu HY, Wu BJ, Kulkarni K, Singh R, Tang L and Hu M. Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. J. Pharm. Biomed. Anal. (2010) 53: 81-89.
14. Wen J, Hong ZY, Wu YW, Wei H, Fan GR and Wu YT. Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: Application to the pharmacokinetic study in healthy Chinese volunteers. J. Pharm. Biomed. Anal. (2009) 49: 347-353.
15. Tsai PL and Tsai TH. Hepatobiliary excretion of berberine. Drug Metab. Dispos. (2004) 32: 405-412.
16. Li YH, Duan JP, Guo TT, Xie W, Yan SN, Li B, Zhou YQ and Chen YX. In-vivo pharmacokinetics comparisons of icariin, emodin and psoralen from Gan-kang granules and extracts of Herba Epimedii, Nepal dock root, Ficus hirta Yahl. J. Ethnopharmacol. (2009) 124: 522-529.