Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 915-916, Issue , 2013, Pages 8-12

  Jiang, Li ^a   Dai, Jundong ^a   Huang, Zhenlin ^a   Du, Qinghua ^a   Lin, Jiahao ^a   Wang, Yurong ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Gastrodin; Interaction; Oral bioavailability; Pharmacokinetics; Puerarin

Indexed keywords

ANALYTES; BIOACTIVE SUBSTANCES; BLOOD SAMPLES; GASTRODIN; HPLC METHOD; INTERACTION; INTERNAL STANDARDS; LINEAR RANGE; MOBILE PHASE; ORAL BIOAVAILABILITY; PHARMACOKINETIC PROFILES; PHARMACOKINETIC STUDIES; PUERARIN; RADIX PUERARIAE; RAT PLASMA; SIMULTANEOUS DETERMINATIONS; TIME POINTS; TRADITIONAL CHINESE MEDICINE; TYROSOL;

BIOCHEMISTRY; BODY FLUIDS; COLUMN CHROMATOGRAPHY; METHANOL; ORGANIC COMPOUNDS; PHARMACOKINETICS; PHOSPHORIC ACID; RATS;

GASES;

GASTRODIN; PUERARIN;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BENZYL ALCOHOLS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; DRUGS, CHINESE HERBAL; GASTRODIA; GLUCOSIDES; ISOFLAVONES; MALE; PUERARIA; RANDOM ALLOCATION; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS;

GASTRODIA ELATA; RATTUS;

EID: 84872412160     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.12.011     Document Type: Article

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