A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study

Bioanalysis

Volumn 4, Issue 10, 2012, Pages 1205-1213

  Huang, Ping ^a   Gao, Jing Wen ^a   Shi, Zhan ^a   Zou, Jia Li ^b   Lu, Ya Song ^c   Yuan, Yue Mei ^a   Yao, Mei Cun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Inpatients Pharmacy   (China)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAICALIN; BERBERINE; CHINESE DRUG; DAHUANG HUANGLIAN XIEXIN; EMODIN; RHEIN; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG METABOLISM; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

ANIMALS; ANTHRAQUINONES; BERBERINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONIC DISEASES, FUNCTIONAL; DRUGS, CHINESE HERBAL; EMODIN; FLAVONOIDS; MEDICINE, CHINESE TRADITIONAL; PLASMA; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; TANDEM MASS SPECTROMETRY;

EID: 84861867782     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.81     Document Type: Article

References (11)

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