ECSIT bridges RIG-I-Like receptors to VISA in signaling events of innate antiviral responses

Journal of Innate Immunity

Volumn 7, Issue 2, 2015, Pages 153-164

  Lei, Cao Qi ^a   Zhang, Yu ^a   Li, Mi ^a   Jiang, Li Qun ^a   Zhong, Bo ^a   Kim, Yong Ho ^a,b   Shu, Hong Bing ^a  

^a WUHAN UNIVERSITY   (China)

^b KIM IL SUNG UNIVERSITY   (North Korea)

Author keywords

ECSIT; Innate immunity; Interferon; RIG I; Signaling; Virus; VISA

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR 3; PROTEIN DERIVATIVE; PROTEIN ECSIT; PROTEIN MDA5; PROTEIN VISA; RETINOIC ACID INDUCIBLE PROTEIN I; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; BETA INTERFERON; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; ECSIT PROTEIN, HUMAN; IFIH1 PROTEIN, HUMAN; IRF3 PROTEIN, HUMAN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; VIRUS ANTIGEN; VISA PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INNATE IMMUNITY; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS INFECTION; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; TRANSGENE; VIRUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, VIRAL; DEAD-BOX RNA HELICASES; GENE EXPRESSION REGULATION, VIRAL; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MITOCHONDRIA; PROTEIN BINDING; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSGENES; VIRUS DISEASES; VIRUSES;

EID: 84924044203     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000365971     Document Type: Article

References (33)

1. Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006; 124: 783-801
2. Hiscott J: Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine Growth Factor Rev 2007; 18: 483-490
3. Randall RE, Goodbourn S: Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 2008; 89: 1-47
4. Chiu YH, Macmillan JB, Chen ZJ: RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009; 138: 576-591
5. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA: Recognition of double-stranded RNA and activation of NF-kappaB by Tolllike receptor 3. Nature 2001; 413: 732-738
6. Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S, Randall RE: The V proteins of paramyxoviruses bind the IFNinducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci USA 2004; 101: 17264-17269
7. Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004; 5: 730-737
8. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB: LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci USA 2012; 109: 11770-11775
9. Yoneyama M, Fujita T: Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity 2008; 29: 178-181
10. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S: IPS-1, an adaptor triggering RIG-I-and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6: 981-988
11. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB: VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 2005; 19: 727-740
12. Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005; 437: 1167-1172
13. Seth RB, Sun L, Ea CK, Chen ZJ: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 2005; 122: 669-682
14. Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU: TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 2007; 446: 916-920
15. Liu HM, Loo YM, Horner SM, Zornetzer GA, Katze MG, Gale M Jr: The mitochondrial targeting chaperone 14-3-3 regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. Cell Host Microbe 2012; 11: 528-537
16. Ohman T, Rintahaka J, Kalkkinen N, Matikainen S, Nyman TA: Actin and RIG-I/MAVS signaling components translocate to mitochondria upon influenza A virus infection of human primary macrophages. J Immunol 2009; 182: 5682-5692
17. Xu L, Xiao N, Liu F, Ren H, Gu J: Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. Proc Natl Acad Sci USA 2009; 106: 1530-1535
18. Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S: ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev 1999; 13: 2059-2071
19. Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S: Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev 2003; 17: 2933-2949
20. Vogel RO, Janssen RJ, van den Brand MA, Dieteren CE, Verkaart S, Koopman WJ, Willems PH, Pluk W, van den Heuvel LP, Smeitink JA, Nijtmans LG: Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Genes Dev 2007; 21: 615-624
21. West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS, Ghosh S: TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 2011; 472: 476-480
22. Kondo T, Watanabe M, Hatakeyama S: TRIM59 interacts with ECSIT and negatively regulates NF-kappaB and IRF-3/7-mediated signal pathways. Biochem Biophys Res Commun 2012; 422: 501-507
23. Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S, Shu HB: Glycogen synthase kinase 3 regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity 2010; 33: 878-889
24. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB: The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 2008; 29: 538-550
25. Zhang J, Hu MM, Wang YY, Shu HB: TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem 2012; 287: 28646-28655
26. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB: FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. J Biol Chem 2013; 288: 12596-12604
27. Wang S, Wang K, Lin R, Zheng C: Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production. J Virol 2013; 87: 12814-12827
28. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB: Kruppel-like factor 6 is a co-activator of NF-kappaB that mediates p65-dependent transcription of selected downstream genes. J Biol Chem 2014; 289: 12876-12885
29. Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, Hiiragi A, Dermody TS, Fujita T, Akira S: Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med 2008; 205: 1601-1610
30. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006; 441: 101-105
31. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P, Shu HB: Negative regulation of MDA5-but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. Proc Natl Acad Sci USA 2007; 104: 11706-11711
32. Gitlin L, Benoit L, Song C, Cella M, Gilfillan S, Holtzman MJ, Colonna M: Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. PLoS Pathog 2010; 6:e1000734
33. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y, Shu HB: RAVER1 is a coactivator of MDA5-mediated cellular antiviral response. J Mol Cell Biol 2013; 5: 111-119.