메뉴 건너뛰기




Volumn 13, Issue 2, 2015, Pages 293-304

WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; HISTONE METHYLTRANSFERASE; UNCLASSIFIED DRUG; WOLF HIRSCHHORN SYNDROME CANDIDATE 1; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; NEK7 PROTEIN, HUMAN; NIMA RELATED KINASE; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; WHSC1 PROTEIN, HUMAN;

EID: 84923876890     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-14-0292-T     Document Type: Article
Times cited : (88)

References (55)
  • 1
    • 84865642314 scopus 로고    scopus 로고
    • RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation
    • Cho HS, Hayami S, ToyokawaG, Maejima K, Yamane Y, Suzuki T, et al. RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. Neoplasia 2012;14:476-86.
    • (2012) Neoplasia , vol.14 , pp. 476-486
    • Cho, H.S.1    Hayami, S.2    Toyokawa, G.3    Maejima, K.4    Yamane, Y.5    Suzuki, T.6
  • 2
    • 79551519643 scopus 로고    scopus 로고
    • Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells
    • Cho HS, Suzuki T, Dohmae N, Hayami S, Unoki M, Yoshimatsu M, et al. Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Res 2011;71:1-6.
    • (2011) Cancer Res , vol.71 , pp. 1-6
    • Cho, H.S.1    Suzuki, T.2    Dohmae, N.3    Hayami, S.4    Unoki, M.5    Yoshimatsu, M.6
  • 3
    • 77949468885 scopus 로고    scopus 로고
    • Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: Involvement in the proliferation of cancer cells through the E2F/RB pathway
    • Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer 2010;9:59.
    • (2010) Mol Cancer , vol.9 , pp. 59
    • Hayami, S.1    Yoshimatsu, M.2    Veerakumarasivam, A.3    Unoki, M.4    Iwai, Y.5    Tsunoda, T.6
  • 4
    • 84879414983 scopus 로고    scopus 로고
    • The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer
    • Ezponda T, Popovic R, Shah MY, Martinez-Garcia E, Zheng Y, Min DJ, et al. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene 2013;32:2882-90.
    • (2013) Oncogene , vol.32 , pp. 2882-2890
    • Ezponda, T.1    Popovic, R.2    Shah, M.Y.3    Martinez-Garcia, E.4    Zheng, Y.5    Min, D.J.6
  • 5
    • 77957935103 scopus 로고    scopus 로고
    • Linking cell signaling and the epigenetic machinery
    • Mohammad HP, Baylin SB. Linking cell signaling and the epigenetic machinery. Nat Biotech 2010;28:1033-8.
    • (2010) Nat Biotech , vol.28 , pp. 1033-1038
    • Mohammad, H.P.1    Baylin, S.B.2
  • 6
    • 79952377463 scopus 로고    scopus 로고
    • Resistance, epigenetics and the cancer ecosystem
    • Baylin SB. Resistance, epigenetics and the cancer ecosystem. Nat Med 2011;17:288-9.
    • (2011) Nat Med , vol.17 , pp. 288-289
    • Baylin, S.B.1
  • 7
  • 9
    • 43249102851 scopus 로고    scopus 로고
    • Erasing themethyl mark: Histone demethylases at the center of cellular differentiation and disease
    • Cloos PA, Christensen J, Agger K, Helin K. Erasing themethyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 2008;22:1115-40.
    • (2008) Genes Dev , vol.22 , pp. 1115-1140
    • Cloos, P.A.1    Christensen, J.2    Agger, K.3    Helin, K.4
  • 10
    • 69949148388 scopus 로고    scopus 로고
    • Protein methyltransferases as a target class for drug discovery
    • Copeland RA, Solomon ME, Richon VM. Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov 2009;8: 724-32.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 724-732
    • Copeland, R.A.1    Solomon, M.E.2    Richon, V.M.3
  • 11
    • 84860215207 scopus 로고    scopus 로고
    • Molecular mechanisms and potential functions of histone demethylases
    • Kooistra SM, Helin K. Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 2012;13:297-311.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 297-311
    • Kooistra, S.M.1    Helin, K.2
  • 12
    • 33845786515 scopus 로고    scopus 로고
    • The control of histone lysine methylation in epigenetic regulation
    • Volkel P, Angrand PO. The control of histone lysine methylation in epigenetic regulation. Biochimie 2007;89:1-20.
    • (2007) Biochimie , vol.89 , pp. 1-20
    • Volkel, P.1    Angrand, P.O.2
  • 14
    • 80054818729 scopus 로고    scopus 로고
    • Histone lysine methyltransferase wolf-hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway
    • Toyokawa G, Cho HS, Masuda K, Yamane Y, Yoshimatsu M, Hayami S, et al. Histone lysine methyltransferase wolf-hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. Neoplasia 2011;13:887-98.
    • (2011) Neoplasia , vol.13 , pp. 887-898
    • Toyokawa, G.1    Cho, H.S.2    Masuda, K.3    Yamane, Y.4    Yoshimatsu, M.5    Hayami, S.6
  • 15
    • 79955506975 scopus 로고    scopus 로고
    • The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors
    • Hudlebusch HR, Santoni-Rugiu E, Simon R, Ralfkiaer E, Rossing HH, Johansen JV, et al. The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res 2011;17:2919-33.
    • (2011) Clin Cancer Res , vol.17 , pp. 2919-2933
    • Hudlebusch, H.R.1    Santoni-Rugiu, E.2    Simon, R.3    Ralfkiaer, E.4    Rossing, H.H.5    Johansen, J.V.6
  • 16
    • 0031779421 scopus 로고    scopus 로고
    • WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
    • Stec I, Wright TJ, van Ommen GJ, de Boer PA, van Haeringen A, Moorman AF, et al. WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma. Hum Mol Genet 1998;7:1071-82.
    • (1998) Hum Mol Genet , vol.7 , pp. 1071-1082
    • Stec, I.1    Wright, T.J.2    Van Ommen, G.J.3    De Boer, P.A.4    Van Haeringen, A.5    Moorman, A.F.6
  • 17
    • 38349087546 scopus 로고    scopus 로고
    • The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity
    • Lauring J, Abukhdeir AM, Konishi H, Garay JP, Gustin JP, Wang Q, et al. The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. Blood 2008;111: 856-64.
    • (2008) Blood , vol.111 , pp. 856-864
    • Lauring, J.1    Abukhdeir, A.M.2    Konishi, H.3    Garay, J.P.4    Gustin, J.P.5    Wang, Q.6
  • 18
    • 78650978001 scopus 로고    scopus 로고
    • The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells
    • Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, et al. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood 2011;117:211-20.
    • (2011) Blood , vol.117 , pp. 211-220
    • Martinez-Garcia, E.1    Popovic, R.2    Min, D.J.3    Sweet, S.M.4    Thomas, P.M.5    Zamdborg, L.6
  • 19
    • 81355133161 scopus 로고    scopus 로고
    • NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming
    • Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, et al. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell 2011;44:609-20.
    • (2011) Mol Cell , vol.44 , pp. 609-620
    • Kuo, A.J.1    Cheung, P.2    Chen, K.3    Zee, B.M.4    Kioi, M.5    Lauring, J.6
  • 20
    • 79551665780 scopus 로고    scopus 로고
    • MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
    • Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, et al. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature 2011;470:124-8.
    • (2011) Nature , vol.470 , pp. 124-128
    • Pei, H.1    Zhang, L.2    Luo, K.3    Qin, Y.4    Chesi, M.5    Fei, F.6
  • 24
    • 78649815150 scopus 로고    scopus 로고
    • Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
    • Hayami S, Kelly JD, ChoHS, YoshimatsuM,UnokiM, Tsunoda T, et al. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer 2011;128: 574-86.
    • (2011) Int J Cancer , vol.128 , pp. 574-586
    • Hayami, S.1    Kelly, J.D.2    Cho, H.S.3    Yoshimatsu, M.4    Unoki, M.5    Tsunoda, T.6
  • 25
    • 78649638594 scopus 로고    scopus 로고
    • Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers
    • Yoshimatsu M, ToyokawaG, Hayami S, UnokiM, Tsunoda T, Field HI, et al. Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer 2011;128: 562-73.
    • (2011) Int J Cancer , vol.128 , pp. 562-573
    • Yoshimatsu, M.1    Toyokawa, G.2    Hayami, S.3    Unoki, M.4    Tsunoda, T.5    Field, H.I.6
  • 26
    • 4143074854 scopus 로고    scopus 로고
    • SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
    • Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, LiM, et al. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol 2004;6:731-40.
    • (2004) Nat Cell Biol , vol.6 , pp. 731-740
    • Hamamoto, R.1    Furukawa, Y.2    Morita, M.3    Iimura, Y.4    Silva, F.P.5    Li, M.6
  • 28
    • 80051543424 scopus 로고    scopus 로고
    • Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1
    • Cho HS, Kelly JD, Hayami S, Toyokawa G, Takawa M, Yoshimatsu M, et al. Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. Neoplasia 2011;13: 676-84.
    • (2011) Neoplasia , vol.13 , pp. 676-684
    • Cho, H.S.1    Kelly, J.D.2    Hayami, S.3    Toyokawa, G.4    Takawa, M.5    Yoshimatsu, M.6
  • 29
    • 83055162300 scopus 로고    scopus 로고
    • The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6
    • Toyokawa G, Cho HS, Iwai Y, Yoshimatsu M, Takawa M, Hayami S, et al. The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. Cancer Prev Res 2011;4:2051-61.
    • (2011) Cancer Prev Res , vol.4 , pp. 2051-2061
    • Toyokawa, G.1    Cho, H.S.2    Iwai, Y.3    Yoshimatsu, M.4    Takawa, M.5    Hayami, S.6
  • 30
    • 84863579070 scopus 로고    scopus 로고
    • Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression
    • Takawa M, Cho HS, Hayami S, Toyokawa G, Kogure M, Yamane Y, et al. Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Res 2012;72:3217-27.
    • (2012) Cancer Res , vol.72 , pp. 3217-3227
    • Takawa, M.1    Cho, H.S.2    Hayami, S.3    Toyokawa, G.4    Kogure, M.5    Yamane, Y.6
  • 31
    • 84878972592 scopus 로고    scopus 로고
    • Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G/S transition
    • Kogure M, Takawa M, Cho HS, Toyokawa G, Hayashi K, Tsunoda T, et al. Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G/S transition. Cancer Lett 2013; 336:76-84.
    • (2013) Cancer Lett , vol.336 , pp. 76-84
    • Kogure, M.1    Takawa, M.2    Cho, H.S.3    Toyokawa, G.4    Hayashi, K.5    Tsunoda, T.6
  • 32
    • 84861574307 scopus 로고    scopus 로고
    • The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene
    • Cho HS, Toyokawa G, Daigo Y, Hayami S, Masuda K, Ikawa N, et al. The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene. Int J Cancer 2012;131:E179-89.
    • (2012) Int J Cancer , vol.131 , pp. E179-E189
    • Cho, H.S.1    Toyokawa, G.2    Daigo, Y.3    Hayami, S.4    Masuda, K.5    Ikawa, N.6
  • 33
    • 84871044765 scopus 로고    scopus 로고
    • The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis
    • Kang D, Cho HS, Toyokawa G, Kogure M, Yamane Y, Iwai Y, et al. The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis. Genes Chromosomes Cancer 2013;52:126-39.
    • (2013) Genes Chromosomes Cancer , vol.52 , pp. 126-139
    • Kang, D.1    Cho, H.S.2    Toyokawa, G.3    Kogure, M.4    Yamane, Y.5    Iwai, Y.6
  • 34
    • 84888409855 scopus 로고    scopus 로고
    • The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination
    • Kogure M, Takawa M, Saloura V, Sone K, Piao L, Ueda K, et al. The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination. Neoplasia 2013;15:1251-61.
    • (2013) Neoplasia , vol.15 , pp. 1251-1261
    • Kogure, M.1    Takawa, M.2    Saloura, V.3    Sone, K.4    Piao, L.5    Ueda, K.6
  • 35
    • 67650021805 scopus 로고    scopus 로고
    • The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis
    • O'Regan L, Fry AM. The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Mol Cell Biol 2009;29:3975-90.
    • (2009) Mol Cell Biol , vol.29 , pp. 3975-3990
    • O'Regan, L.1    Fry, A.M.2
  • 36
    • 84872171489 scopus 로고    scopus 로고
    • Cell cycle regulation by the NEK family of protein kinases
    • Fry AM, O'Regan L, Sabir SR, Bayliss R. Cell cycle regulation by the NEK family of protein kinases. J Cell Sci 2012;125:4423-33.
    • (2012) J Cell Sci , vol.125 , pp. 4423-4433
    • Fry, A.M.1    O'Regan, L.2    Sabir, S.R.3    Bayliss, R.4
  • 37
    • 2342443733 scopus 로고    scopus 로고
    • JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in du 145 prostate carcinoma cells
    • Curtin JF, Cotter TG. JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells. J Biol Chem 2004;279:17090-100.
    • (2004) J Biol Chem , vol.279 , pp. 17090-17100
    • Curtin, J.F.1    Cotter, T.G.2
  • 38
    • 79251613647 scopus 로고    scopus 로고
    • Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and nonstem cells
    • Boivin A, Hanot M, Malesys C, Maalouf M, Rousson R, Rodriguez-Lafrasse C, et al. Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and nonstem cells. PLoS ONE 2011;6:e14558.
    • (2011) PLoS ONE , vol.6
    • Boivin, A.1    Hanot, M.2    Malesys, C.3    Maalouf, M.4    Rousson, R.5    Rodriguez-Lafrasse, C.6
  • 39
    • 80054965703 scopus 로고    scopus 로고
    • Nek family of kinases in cell cycle, checkpoint control and cancer
    • Moniz L, Dutt P,Haider N, Stambolic V. Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div 2011;6:18.
    • (2011) Cell Div , vol.6 , pp. 18
    • Moniz, L.1    Dutt, P.2    Haider, N.3    Stambolic, V.4
  • 40
    • 84883244114 scopus 로고    scopus 로고
    • Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression
    • Patil M, Pabla N, Ding HF, Dong Z. Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression. Cell Cycle 2013;12:2608-16.
    • (2013) Cell Cycle , vol.12 , pp. 2608-2616
    • Patil, M.1    Pabla, N.2    Ding, H.F.3    Dong, Z.4
  • 41
    • 84886808679 scopus 로고    scopus 로고
    • Chromatin proteins and modifications as drug targets
    • Helin K, Dhanak D. Chromatin proteins and modifications as drug targets. Nature 2013;502:480-8.
    • (2013) Nature , vol.502 , pp. 480-488
    • Helin, K.1    Dhanak, D.2
  • 42
    • 84863710071 scopus 로고    scopus 로고
    • New lysine methyltransferase drug targets in cancer
    • Wagner T, Jung M.New lysine methyltransferase drug targets in cancer.Nat Biotech 2012;30:622-3.
    • (2012) Nat Biotech , vol.30 , pp. 622-623
    • Wagner, T.1    Jung, M.2
  • 44
    • 84877954369 scopus 로고    scopus 로고
    • Histone methyltransferase inhibitors: Novel epigenetic agents for cancer treatment
    • Zagni C, Chiacchio U, Rescifina A. Histone methyltransferase inhibitors: novel epigenetic agents for cancer treatment. Curr Med Chem 2013;20: 167-85.
    • (2013) Curr Med Chem , vol.20 , pp. 167-185
    • Zagni, C.1    Chiacchio, U.2    Rescifina, A.3
  • 45
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012;492:108-12.
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3    Korenchuk, S.4    Thompson, C.5    Van Aller, G.S.6
  • 46
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    • Qi W, Chan H, Teng L, Li L, Chuai S, Zhang R, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A 2012;109:21360-5.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 21360-21365
    • Qi, W.1    Chan, H.2    Teng, L.3    Li, L.4    Chuai, S.5    Zhang, R.6
  • 47
    • 67650461956 scopus 로고    scopus 로고
    • A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome
    • Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, Schwartz RJ, et al. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 2009;460:287-91.
    • (2009) Nature , vol.460 , pp. 287-291
    • Nimura, K.1    Ura, K.2    Shiratori, H.3    Ikawa, M.4    Okabe, M.5    Schwartz, R.J.6
  • 48
    • 84863021027 scopus 로고    scopus 로고
    • NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells
    • Kim S, Kim S, Rhee K. NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells. J Cell Sci 2011;124:3760-70.
    • (2011) J Cell Sci , vol.124 , pp. 3760-3770
    • Kim, S.1    Kim, S.2    Rhee, K.3
  • 49
    • 40549126830 scopus 로고    scopus 로고
    • Mitotic regulation by NIMA-related kinases
    • O'Regan L, Blot J, Fry AM. Mitotic regulation by NIMA-related kinases. Cell Div 2007;2:25.
    • (2007) Cell Div , vol.2 , pp. 25
    • O'Regan, L.1    Blot, J.2    Fry, A.M.3
  • 50
    • 79960056092 scopus 로고    scopus 로고
    • Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5
    • Bertran MT, Sdelci S, Regue L, Avruch J, Caelles C, Roig J. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J 2011;30:2634-47.
    • (2011) EMBO J , vol.30 , pp. 2634-2647
    • Bertran, M.T.1    Sdelci, S.2    Regue, L.3    Avruch, J.4    Caelles, C.5    Roig, J.6
  • 51
    • 84880268319 scopus 로고    scopus 로고
    • The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival
    • Wang R, Song Y, Xu X, Wu Q, Liu C. The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival. Clin Transl Oncol 2013;15:626-32.
    • (2013) Clin Transl Oncol , vol.15 , pp. 626-632
    • Wang, R.1    Song, Y.2    Xu, X.3    Wu, Q.4    Liu, C.5
  • 54
    • 35448935555 scopus 로고    scopus 로고
    • Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma
    • Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M. Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma. Cancer Res 2007;67: 9637-42.
    • (2007) Cancer Res , vol.67 , pp. 9637-9642
    • Kokuryo, T.1    Senga, T.2    Yokoyama, Y.3    Nagino, M.4    Nimura, Y.5    Hamaguchi, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.