ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes

Endocrinology (United States)

Volumn 156, Issue 3, 2015, Pages 869-881

  Solt, Laura A ^a   Banerjee, Subhashis ^a   Campbell, Sean ^a   Kamenecka, Theodore M ^a   Burris, Thomas P ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AUTOANTIBODY; GLUTAMATE DECARBOXYLASE 65; INSULIN; INSULIN ANTIBODY; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 6; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR GAMMA; RETINOIC ACID RECEPTOR GAMMA T; SR 1001; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RORA PROTEIN, MOUSE; SR1001; SULFONAMIDE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; DIABETOGENESIS; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HISTOLOGY; HYPERGLYCEMIA; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; TH1 CELL; TH17 CELL; AGONISTS; ANIMAL; BLOOD; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE;

ANIMALS; AUTOANTIBODIES; CYTOKINES; DIABETES MELLITUS, TYPE 1; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; INSULIN; MICE; MICE, INBRED NOD; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; SULFONAMIDES; TH17 CELLS; THIAZOLES;

EID: 84923870123     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1677     Document Type: Article

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