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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 6, 2015, Pages 1318-1323

Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives

(7) Bazin, Hélène G a Li, Yufeng a Khalaf, Juhienah K a,b Mwakwari, Sandra a Livesay, Mark T a Evans, Jay T a Johnson, David A a

a GLAXOSMITHKLINE (United States)

b OMEROS CORPORATION (United States)

Author keywords

Immunostimulants; Oxoadenine; TLR7 8 agonist

Indexed keywords

ADENINE DERIVATIVE; ALKYL GROUP; ALPHA INTERFERON; CYTOKINE; PIPERIDINE DERIVATIVE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 7 AGONIST; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 8 AGONIST; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; 8-HYDROXYADENINE; ADENINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; METABOLISM; MONONUCLEAR CELL; SYNTHESIS;

ADENINE; CELL SURVIVAL; HEK293 CELLS; HUMANS; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; NF-KAPPA B; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TRANSFECTION;

EID: 84923863473 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.01.037 Document Type: Article

Times cited : (24)

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