Synthesis of 6-substituted 9-benzyl-8-hydroxypurines with potential interferon-inducing activity

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 5, 2003, Pages 608-611

  Kazaoka, Kazunori ^a   Sajiki, Hironao ^a   Hirota, Kosaku ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

5 amino 4 cyano 2 hydroxyimidazole; 8 hydroxypurine; 9 benzyl 8 hydroxyadenine; Interferon inducing activity; Reductive alkylation

Indexed keywords

5 AMINO 1 BENZYL 4 CYANO 2 HYDROXYIMIDAZOLE; 5 AMINO 4 BENZYLAMINO 6 CHLOROPYRIMIDINE; 9 BENZYL 6,8 DIHYDROXYPURINE; 9 BENZYL 8 HYDROXY 6 MERCAPTOPURINE; 9 BENZYL 8 HYDROXY 6 METHOXYPURINE; 9 BENZYL 8 HYDROXY 6 METHYLTHIOPURINE; 9 BENZYL 8 HYDROXY N 6 ISOBUTYLADENINE; 9 BENZYL 8 HYDROXY N 6 METHYLADENINE; 9 BENZYL 8 HYDROXY N 6 PROPYLADENINE; 9 BENZYL 8 HYDROXY N 6 TRIFLUOROACETYLADENINE; 9 BENZYL 8 HYDROXYADENINE; 9 BENZYL 8 HYDROXYPURINE; 9 BENZYL N 6 BUTYL 8 HYDROXYADENINE; 9 BENZYL N 6 ETHYL 8 HYDROXYADENINE; BENZYL DERIVATIVE; IMIDAZOLE DERIVATIVE; INTERFERON; N 6 ACETYL 9 BENZYL 8 HYDROXYADENINE; N 6 BENZOYL 9 BENZYL 8 HYDROXYADENINE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; INTERFERON INDUCING AGENT;

ACYLATION; ALKYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; C3H MOUSE; CELL CULTURE; CYTOLOGY; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; METABOLISM; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SPLEEN; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; BENZYL COMPOUNDS; CELLS, CULTURED; INDICATORS AND REAGENTS; INTERFERON INDUCERS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MICE, INBRED C3H; PURINES; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0642340613     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.608     Document Type: Article

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