Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of app processing

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Camargo, Luiz Miguel ^a,c   Zhang, Xiaohua Douglas ^a   Loerch, Patrick ^a   Caceres, Ramon Miguel ^a   Marine, Shane D ^a   Uva, Paolo ^a,d   Ferrer, Marc ^a,e   De Rinaldis, Emanuele ^a,f   Stone, David J ^a   Majercak, John ^a,g   Ray, William J ^a,h   Chen, Yi An ^b   Shearman, Mark S ^a,i   Mizuguchi, Kenji ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d UO di Fisica Sanitaria   (Italy)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f GUY S HOSPITAL   (United Kingdom)

^g BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^h TAKEDA PHARMACEUTICALS   (United States)

ⁱ Merck Serono   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; SMALL INTERFERING RNA; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; SERUM AMYLOID A;

ALZHEIMER DISEASE; ARTICLE; BIN1 GENE; CELL VIABILITY; CLU GENE; CONTROLLED STUDY; CR1 GENE; DSG2 GENE; EPH1A GENE; HUMAN; HUMAN CELL; MEF2C GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; PICALM GENE; PROTEIN DEGRADATION; PROTEIN PROCESSING; REGULATORY MECHANISM; SORL1 GENE; SYNAPTIC TRANSMISSION; SYSTEMS BIOLOGY; TREM2 GENE; CELL SURVIVAL; GENETIC PROCEDURES; GENOME-WIDE ASSOCIATION STUDY; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; CELL SURVIVAL; DIABETES MELLITUS, TYPE 2; GENETIC TECHNIQUES; GENOME-WIDE ASSOCIATION STUDY; HUMANS; METABOLIC NETWORKS AND PATHWAYS; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; RNA, SMALL INTERFERING; SERUM AMYLOID A PROTEIN;

EID: 84923820249     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115369     Document Type: Article

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