Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: Cutting edge and cleavage sites

Journal of Biological Chemistry

Volumn 290, Issue 9, 2015, Pages 5241-5255

  Ji, Hong Long ^a   Zhao, Runzhen ^a   Komissarov, Andrey A ^a   Chang, Yongchang ^b   Liu, Yongfeng ^c   Matthay, Michael A ^d  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^b BARROW NEUROLOGICAL INSTITUTE   (United States)

^c XINXIANG MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAINS; CHEMICAL ACTIVATION; MOBILE SECURITY; SODIUM; TOXIC MATERIALS;

BENEFICIAL EFFECTS; CURRENT AMPLITUDE; ENZYMATIC ACTIVITIES; EPITHELIAL SODIUM CHANNELS; PLASMINOGEN ACTIVATOR INHIBITOR-1; TISSUE-TYPE PLASMINOGEN ACTIVATOR (TPA); TRUNCATION MUTANTS; UROKINASE PLASMINOGEN;

ENZYME INHIBITION;

EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL ALPHA SUBUNIT; EPITHELIAL SODIUM CHANNEL BETA SUBUNIT; EPITHELIAL SODIUM CHANNEL GAMMA SUBUNIT; TENECTEPLASE; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UROKINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN BINDING; SODIUM;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL STIMULATION; CELL SURFACE; CLEAVAGE SITE; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SPECIFICITY; FEMALE; HYDROGEN BOND; MOLECULAR WEIGHT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SODIUM CURRENT; STRUCTURE ACTIVITY RELATION; UPREGULATION; VOLTAGE CLAMP TECHNIQUE; WILD TYPE; XENOPUS LAEVIS; ANIMAL; BINDING SITE; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; WESTERN BLOTTING;

ANIMALS; BINDING SITES; BLOTTING, WESTERN; CATALYTIC DOMAIN; EPITHELIAL SODIUM CHANNELS; FEMALE; HUMANS; ION CHANNEL GATING; KINETICS; MODELS, MOLECULAR; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; SODIUM; UP-REGULATION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; XENOPUS LAEVIS;

EID: 84923763289     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.623496     Document Type: Article

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