Serine protease activation of near-silent epithelial Na+ channels

American Journal of Physiology - Cell Physiology

Volumn 286, Issue 1 55-1, 2004, Pages

  Caldwell, Ray A ^a   Boucher, Richard C ^a   Stutts, M Jackson ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Cystic fibrosis; Epithelial Na+ transport; Hypertension; Protease; Silent channels

Indexed keywords

SERINE PROTEINASE; SODIUM CHANNEL; TRYPSIN;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL MEMBRANE; CELL MEMBRANE CONDUCTANCE; CELL SURFACE; CHANNEL GATING; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM; FLUID BALANCE; NONHUMAN; PRIORITY JOURNAL; SODIUM TRANSPORT;

ANIMALIA; INSERTION SEQUENCES;

EID: 0347988218     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00342.2003     Document Type: Article

References (20)

1. Adachi M, Kitamura K, Miyoshi T, Narikiyo T, Iwashita K, Shiraishi N, Nonoguchi H, and Tomita K. Activation of epithelial sodium channels by prostasin in Xenopus oocytes. J Am Soc Nephrol 12: 1114-1121, 2001.
2. Bridges RJ, Newton BB, Pilewski JM, Devor DC, Poll CT, and Hall RL. Na transport in normal and CF human bronchial epithelial cells is inhibited by BAY 39-9437. Am J Physiol Lung Cell Mol Physiol 281: L16-L23, 2001.
3. Chraibi A, Vallet V, Firsov D, Hess SK, and Horisberger JD. Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes. J Gen Physiol 111: 127-138, 1998.
4. Dempster J. Computer Analysis of Electrophysiological Signals. New York: Academic, 1993.
5. Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, and Gabriel SE. Regulation of the epithelial sodium channel by serine proteases in human airways. J Biol Chem 277: 8338-8345, 2002.
6. Firsov D, Schild L, Gautschi I, Merillat AM, Schneeberger E, and Rossier BC. Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach. Proc Natl Acad Sci USA 93: 15370-15375, 1996.
7. Frindt G, Masilamani S, Knepper MA, and Palmer LG. Activation of epithelial Na channels during short-term Na deprivation. Am J Physiol Renal Physiol 280: F112-F118, 2001.
8. Gallo-Payet N and Payet MD. Excitation-secretion coupling. In: Cell Physiology Sourcebook (2nd ed.), edited by Sperelakis N. San Diego, CA: Academic, 1998, p. 631-651.
9. + channel involves proteolytic processing of the α- and γ-subunits. J Biol Chem 278: 37073-37082, 2003.
10. Lindau M and Almers W. Structure and function of fusion pores in exocytosis and ectoplasmic membrane fusion. Curr Opin Cell Biol 7: 509-517, 1995.
11. Lollike K and Lindau M. Membrane capacitance techniques to monitor granule exocytosis in neutrophils. J Immunol Methods 232: 111-120, 1999.
12. Martin CB, Mahon GM, Klinger MB, Kay RJ, Symons M, Der CJ, and Whitehead IP. The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. Oncogene 20: 1953-1963, 2001.
13. Masilamani S, Kim GH, Mitchell C, Wade JB, and Knepper MA. Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest 104: R19-R23, 1999.
14. Palmer LG and Frindt G. Conductance and gating of epithelial Na channels from rat cortical collecting tubule. Effects of luminal Na and Li. J Gen Physiol 92: 121-138, 1988.
15. Palmer LG and Frindt G. Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch. J Gen Physiol 107: 35-45. 1996.
16. Rossier BC. The epithelial sodium channel (ENaC): new insights into ENaC gating. Pflügers Arch 446: 314-316, 2003.
17. Sakmann B and Neher E. Geometric parameters of pipettes and membrane patches. In: Single-Channel Recording (2nd ed.), edited by Sakmann B and Neher E. New York: Plenum, 1995, p. 637-650.
18. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, and Boucher RC. CFTR as a cAMP-dependent regulator of sodium channels. Science 269: 847-850, 1995.
19. Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, and Rossier BC. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 389: 607-610, 1997.
20. Vuagniaux G, Vallet V, Jaeger NF, Pfister C, Bens M, Farman N, Courtois-Coutry N, Vandewalle A, Rossier BC, and Hummler E. Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line. J Am Soc Nephrol 11: 828-834, 2000.