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Volumn 18, Issue 3, 2015, Pages 339-343

Animal models in epilepsy research: Legacies and new directions

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; DROSOPHILA MELANOGASTER; EPILEPSY; EPILEPTOGENESIS; EXPERIMENTAL MODEL; HUMAN; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; REVIEW; RODENT MODEL; SEIZURE; ZEBRA FISH; ANIMAL; DISEASE MODEL; HISTORY; TRENDS;

EID: 84923700753     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3934     Document Type: Review
Times cited : (201)

References (103)
  • 1
    • 0026020342 scopus 로고
    • Animal models as simulations of depression
    • Willner, P. Animal models as simulations of depression. Trends Pharmacol. Sci. 12, 131-136 (1991).
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 131-136
    • Willner, P.1
  • 2
    • 0029248133 scopus 로고
    • Animal models relevant to human epilepsies
    • Avanzini, G. Animal models relevant to human epilepsies. Ital. J. Neurol. Sci. 16, 5-8 (1995).
    • (1995) Ital. J. Neurol. Sci. , vol.16 , pp. 5-8
    • Avanzini, G.1
  • 4
    • 9344257316 scopus 로고    scopus 로고
    • Laboratory animal models of temporal lobe epilepsy
    • Buckmaster, P.S. Laboratory animal models of temporal lobe epilepsy. Comp. Med. 54, 473-485 (2004).
    • (2004) Comp. Med. , vol.54 , pp. 473-485
    • Buckmaster, P.S.1
  • 6
    • 84934438760 scopus 로고    scopus 로고
    • Aligning animal models with clinical epilepsy: Where to begin?
    • Harward, S.C. & McNamara, J.O. Aligning animal models with clinical epilepsy: where to begin? Adv. Exp. Med. Biol. 813, 243-251 (2014).
    • (2014) Adv. Exp. Med. Biol. , vol.813 , pp. 243-251
    • Harward, S.C.1    McNamara, J.O.2
  • 7
    • 84907210308 scopus 로고    scopus 로고
    • Animal models of epilepsy: Use and limitations
    • Kandratavicius, L. et al. Animal models of epilepsy: use and limitations. Neuropsychiatr. Dis. Treat. 10, 1693-1705 (2014).
    • (2014) Neuropsychiatr. Dis. Treat. , vol.10 , pp. 1693-1705
    • Kandratavicius, L.1
  • 8
    • 79955677603 scopus 로고    scopus 로고
    • Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    • Löscher, W. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure 20, 359-368 (2011).
    • (2011) Seizure , vol.20 , pp. 359-368
    • Löscher, W.1
  • 13
    • 0029592665 scopus 로고
    • Glutamate, GABA and epilepsy
    • Bradford, H.F. Glutamate, GABA and epilepsy. Prog. Neurobiol. 47, 477-511 (1995).
    • (1995) Prog. Neurobiol. , vol.47 , pp. 477-511
    • Bradford, H.F.1
  • 14
    • 84866498805 scopus 로고    scopus 로고
    • Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy
    • Pun, R.Y. et al. Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron 75, 1022-1034 (2012).
    • (2012) Neuron , vol.75 , pp. 1022-1034
    • Pun, R.Y.1
  • 15
    • 84865037901 scopus 로고    scopus 로고
    • Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis
    • Ryan, K., Backos, D.S., Reigan, P. & Patel, M. Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis. J. Neurosci. 32, 11250-11258 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 11250-11258
    • Ryan, K.1    Backos, D.S.2    Reigan, P.3    Patel, M.4
  • 16
    • 0025788142 scopus 로고
    • Scope and contribution of genetic models to an understanding of the epilepsies
    • Jobe, P.C., Mishra, P.K., Ludvig, N. & Dailey, J.W. Scope and contribution of genetic models to an understanding of the epilepsies. Crit. Rev. Neurobiol. 6, 183-220 (1991).
    • (1991) Crit. Rev. Neurobiol. , vol.6 , pp. 183-220
    • Jobe, P.C.1    Mishra, P.K.2    Ludvig, N.3    Dailey, J.W.4
  • 17
    • 0021715587 scopus 로고
    • Genetic animal models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs. A review
    • Löscher, W. Genetic animal models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs. A review. Methods Find. Exp. Clin. Pharmacol. 6, 531-547 (1984).
    • (1984) Methods Find. Exp. Clin. Pharmacol. , vol.6 , pp. 531-547
    • Löscher, W.1
  • 18
    • 0032613392 scopus 로고    scopus 로고
    • Single-gene models of epilepsy
    • Noebels, J.L. Single-gene models of epilepsy. Adv. Neurol. 79, 227-238 (1999).
    • (1999) Adv. Neurol. , vol.79 , pp. 227-238
    • Noebels, J.L.1
  • 19
    • 0033153256 scopus 로고    scopus 로고
    • Seizure disorders in mutant mice: Relevance to human epilepsies
    • Puranam, R.S. & McNamara, J.O. Seizure disorders in mutant mice: relevance to human epilepsies. Curr. Opin. Neurobiol. 9, 281-287 (1999).
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 281-287
    • Puranam, R.S.1    McNamara, J.O.2
  • 21
    • 84923643441 scopus 로고
    • Comparative pathology
    • Anonymous. Comparative pathology. Br. Med. J. 2, 371-372 (1869).
    • (1869) Br. Med. J. , vol.2 , pp. 371-372
    • Anonymous1
  • 22
    • 74949137824 scopus 로고
    • Experimental researches in cerebral physiology and pathology
    • Ferrier, D. Experimental researches in cerebral physiology and pathology. J. Anat. Physiol. 8, 152-155 (1873).
    • (1873) J. Anat. Physiol. , vol.8 , pp. 152-155
    • Ferrier, D.1
  • 23
    • 37049223719 scopus 로고
    • Experimental determination of the anticonvulsant properties of some phenyl derivatives
    • Putnam, T.J. & Merritt, H.H. Experimental determination of the anticonvulsant properties of some phenyl derivatives. Science 85, 525-526 (1937).
    • (1937) Science , vol.85 , pp. 525-526
    • Putnam, T.J.1    Merritt, H.H.2
  • 24
    • 0016663465 scopus 로고
    • Effects of projected cortical epileptiform discharges on neuronal activities in ventrobasal thalamus of the cat: Ictal discharge
    • Gutnick, M.J. & Prince, D.A. Effects of projected cortical epileptiform discharges on neuronal activities in ventrobasal thalamus of the cat: ictal discharge. Exp. Neurol. 46, 418-431 (1975).
    • (1975) Exp. Neurol. , vol.46 , pp. 418-431
    • Gutnick, M.J.1    Prince, D.A.2
  • 25
    • 0014573533 scopus 로고
    • Penicillin-induced interictal discharges from the cat hippocampus. I. Characteristics and topographical features
    • Dichter, M. & Spencer, W.A. Penicillin-induced interictal discharges from the cat hippocampus. I. Characteristics and topographical features. J. Neurophysiol. 32, 649-662 (1969).
    • (1969) J. Neurophysiol. , vol.32 , pp. 649-662
    • Dichter, M.1    Spencer, W.A.2
  • 26
    • 0000943490 scopus 로고
    • The progress of physiology
    • Krogh, A. The progress of physiology. Science 70, 200-204 (1929).
    • (1929) Science , vol.70 , pp. 200-204
    • Krogh, A.1
  • 27
    • 0001058337 scopus 로고
    • Recurrent convulsive seizures in animals produced by immunologic and chemical means
    • Kopeloff, L.M., Barrera, S.E. & Kopeloff, N. Recurrent convulsive seizures in animals produced by immunologic and chemical means. Am. J. Psychiatry 98, 881-902 (1942).
    • (1942) Am. J. Psychiatry , vol.98 , pp. 881-902
    • Kopeloff, L.M.1    Barrera, S.E.2    Kopeloff, N.3
  • 28
    • 84876272458 scopus 로고    scopus 로고
    • Epidemiology and characterization of seizures in a pedigreed baboon colony
    • Szabó, C.Á. et al. Epidemiology and characterization of seizures in a pedigreed baboon colony. Comp. Med. 62, 535-538 (2012).
    • (2012) Comp. Med. , vol.62 , pp. 535-538
    • Szabó, C.Á.1
  • 29
    • 84888079834 scopus 로고    scopus 로고
    • Epileptic baboons have lower numbers of neurons in specific areas of cortex
    • Young, N.A. et al. Epileptic baboons have lower numbers of neurons in specific areas of cortex. Proc. Natl. Acad. Sci. USA 110, 19107-19112 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 19107-19112
    • Young, N.A.1
  • 30
    • 84897451649 scopus 로고    scopus 로고
    • Forecasting seizures in dogs with naturally occurring epilepsy
    • Howbert, J.J. et al. Forecasting seizures in dogs with naturally occurring epilepsy. PLoS ONE 9, e81920 (2014).
    • (2014) PLoS ONE , vol.9
    • Howbert, J.J.1
  • 31
    • 5344234533 scopus 로고    scopus 로고
    • Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures
    • Loscher, W., Potschka, H., Rieck, S., Tipold, A. & Rundfeldt, C. Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. Epilepsia 45, 1228-1239 (2004).
    • (2004) Epilepsia , vol.45 , pp. 1228-1239
    • Loscher, W.1    Potschka, H.2    Rieck, S.3    Tipold, A.4    Rundfeldt, C.5
  • 33
    • 84904439326 scopus 로고    scopus 로고
    • Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury
    • Sakurai, A., Tamvacakis, A.N. & Katz, P.S. Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury. Elife 3, e02598 (2014).
    • (2014) Elife , vol.3
    • Sakurai, A.1    Tamvacakis, A.N.2    Katz, P.S.3
  • 34
    • 0021917797 scopus 로고
    • Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats
    • Tauck, D.L. & Nadler, J.V. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 5, 1016-1022 (1985).
    • (1985) J. Neurosci. , vol.5 , pp. 1016-1022
    • Tauck, D.L.1    Nadler, J.V.2
  • 35
    • 79953177461 scopus 로고    scopus 로고
    • A neuroprotective role for polyamines in a Xenopus tadpole model of epilepsy
    • Bell, M.R., Belarde, J.A., Johnson, H.F. & Aizenman, C.D. A neuroprotective role for polyamines in a Xenopus tadpole model of epilepsy. Nat. Neurosci. 14, 505-512 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 505-512
    • Bell, M.R.1    Belarde, J.A.2    Johnson, H.F.3    Aizenman, C.D.4
  • 36
    • 0030835980 scopus 로고    scopus 로고
    • The cerebral hemisphere of the turtle in vitro. An experimental model with spontaneous interictal-like spikes for the study of epilepsy
    • Velluti, J.C., Costa da Costa, J. & Russo, R.E. The cerebral hemisphere of the turtle in vitro. An experimental model with spontaneous interictal-like spikes for the study of epilepsy. Epilepsy Res. 28, 29-37 (1997).
    • (1997) Epilepsy Res. , vol.28 , pp. 29-37
    • Velluti, J.C.1    Costa Da Costa, J.2    Russo, R.E.3
  • 37
    • 84868589813 scopus 로고    scopus 로고
    • Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra
    • Pamenter, M.E., Hogg, D.W., Gu, X.Q., Buck, L.T. & Haddad, G.G. Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. J. Cereb. Blood Flow Metab. 32, 2033-2043 (2012).
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 2033-2043
    • Pamenter, M.E.1    Hogg, D.W.2    Gu, X.Q.3    Buck, L.T.4    Haddad, G.G.5
  • 38
    • 84984562953 scopus 로고    scopus 로고
    • Introducing songbirds as a model system for epilepsy research
    • Margoliash, D., van Drongelen, W. & Kohrman, M. Introducing songbirds as a model system for epilepsy research. J. Clin. Neurophysiol. 27, 433-437 (2010).
    • (2010) J. Clin. Neurophysiol. , vol.27 , pp. 433-437
    • Margoliash, D.1    Van Drongelen, W.2    Kohrman, M.3
  • 39
    • 0025886451 scopus 로고
    • Transfer of genetic epilepsy by embryonic brain grafts in the chicken
    • Teillet, M.A. et al. Transfer of genetic epilepsy by embryonic brain grafts in the chicken. Proc. Natl. Acad. Sci. USA 88, 6966-6970 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6966-6970
    • Teillet, M.A.1
  • 40
    • 84896294772 scopus 로고    scopus 로고
    • Hippocampal neuropathology of domoic acid-induced epilepsy in California sea lions (Zalophus californianus)
    • Buckmaster, P.S., Wen, X., Toyoda, I., Gulland, F.M. & Van Bonn, W. Hippocampal neuropathology of domoic acid-induced epilepsy in California sea lions (Zalophus californianus). J. Comp. Neurol. 522, 1691-1706 (2014).
    • (2014) J. Comp. Neurol. , vol.522 , pp. 1691-1706
    • Buckmaster, P.S.1    Wen, X.2    Toyoda, I.3    Gulland, F.M.4    Van Bonn, W.5
  • 41
    • 84886179076 scopus 로고    scopus 로고
    • Modeling Alzheimer's disease in transgenic rats
    • Do Carmo, S. & Cuello, A.C. Modeling Alzheimer's disease in transgenic rats. Mol. Neurodegener. 8, 37 (2013).
    • (2013) Mol. Neurodegener. , vol.8 , pp. 37
    • Do Carmo, S.1    Cuello, A.C.2
  • 42
    • 84864044174 scopus 로고    scopus 로고
    • On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools
    • Duranthon, V. et al. On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools. Transgenic Res. 21, 699-713 (2012).
    • (2012) Transgenic Res. , vol.21 , pp. 699-713
    • Duranthon, V.1
  • 43
    • 84900310785 scopus 로고    scopus 로고
    • Modeling amyotrophic lateral sclerosis in hSOD1 transgenic swine
    • Chieppa, M.N. et al. Modeling amyotrophic lateral sclerosis in hSOD1 transgenic swine. Neurodegener. Dis. 13, 246-254 (2014).
    • (2014) Neurodegener. Dis. , vol.13 , pp. 246-254
    • Chieppa, M.N.1
  • 44
    • 84894081986 scopus 로고    scopus 로고
    • Generation of gene-modified cynomolgus monkey via Cas9/RNAmediated gene targeting in one-cell embryos
    • Niu, Y. et al. Generation of gene-modified cynomolgus monkey via Cas9/RNAmediated gene targeting in one-cell embryos. Cell 156, 836-843 (2014).
    • (2014) Cell , vol.156 , pp. 836-843
    • Niu, Y.1
  • 45
    • 0016615294 scopus 로고
    • Spontaneous seizures generated in rats by kindling - preliminary report
    • Pinel, J.P.J., Mucha, R.F. & Phillips, A.G. Spontaneous seizures generated in rats by kindling - preliminary report. Physiol. Psychol. 3, 127-129 (1975).
    • (1975) Physiol. Psychol. , vol.3 , pp. 127-129
    • Pinel, J.P.J.1    Mucha, R.F.2    Phillips, A.G.3
  • 46
    • 34249812350 scopus 로고    scopus 로고
    • The relevance of kindling for human epilepsy
    • Bertram, E. The relevance of kindling for human epilepsy. Epilepsia 48 (suppl. 2), 65-74 (2007).
    • (2007) Epilepsia , vol.48 , pp. 65-74
    • Bertram, E.1
  • 47
    • 68049096002 scopus 로고    scopus 로고
    • Use with caution: Developmental systems divergence and potential pitfalls of animal models
    • Lynch, V.J. Use with caution: developmental systems divergence and potential pitfalls of animal models. Yale J. Biol. Med. 82, 53-66 (2009).
    • (2009) Yale J. Biol. Med. , vol.82 , pp. 53-66
    • Lynch, V.J.1
  • 48
    • 81055156703 scopus 로고    scopus 로고
    • The relevance of individual genetic background and its role in animal models of epilepsy
    • Schauwecker, P.E. The relevance of individual genetic background and its role in animal models of epilepsy. Epilepsy Res. 97, 1-11 (2011).
    • (2011) Epilepsy Res. , vol.97 , pp. 1-11
    • Schauwecker, P.E.1
  • 50
    • 0242403106 scopus 로고    scopus 로고
    • Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology
    • McKhann, G.M. II, Wenzel, H.J., Robbins, C.A., Sosunov, A.A. & Schwartzkroin, P.A. Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology. Neuroscience 122, 551-561 (2003).
    • (2003) Neuroscience , vol.122 , pp. 551-561
    • McKhann, G.M.1    Wenzel, H.J.2    Robbins, C.A.3    Sosunov, A.A.4    Schwartzkroin, P.A.5
  • 51
    • 70949103595 scopus 로고    scopus 로고
    • Adult-born hippocampal neurons are more numerous, faster maturing, and more involved in behavior in rats than in mice
    • Snyder, J.S. et al. Adult-born hippocampal neurons are more numerous, faster maturing, and more involved in behavior in rats than in mice. J. Neurosci. 29, 14484-14495 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 14484-14495
    • Snyder, J.S.1
  • 52
    • 0030907041 scopus 로고    scopus 로고
    • Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
    • Parent, J.M. et al. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 17, 3727-3738 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 3727-3738
    • Parent, J.M.1
  • 53
    • 0033947122 scopus 로고    scopus 로고
    • Kainic acid induction of mossy fiber sprouting: Dependence on mouse strain
    • Cantallops, I. & Routtenberg, A. Kainic acid induction of mossy fiber sprouting: dependence on mouse strain. Hippocampus 10, 269-273 (2000).
    • (2000) Hippocampus , vol.10 , pp. 269-273
    • Cantallops, I.1    Routtenberg, A.2
  • 54
    • 33746871470 scopus 로고    scopus 로고
    • Hippocampal cell loss in posttraumatic human epilepsy
    • Swartz, B.E. et al. Hippocampal cell loss in posttraumatic human epilepsy. Epilepsia 47, 1373-1382 (2006).
    • (2006) Epilepsia , vol.47 , pp. 1373-1382
    • Swartz, B.E.1
  • 55
    • 0000150288 scopus 로고
    • Tottering: A neuromusclar mutation in the mouse. And its linkage with oligosyndacylism
    • Green, M.C. & Sidman, R.L. Tottering: a neuromusclar mutation in the mouse. And its linkage with oligosyndacylism. J. Hered. 53, 233-237 (1962).
    • (1962) J. Hered. , vol.53 , pp. 233-237
    • Green, M.C.1    Sidman, R.L.2
  • 56
    • 0015019475 scopus 로고
    • Evidence for allelism of leaner and tottering in the mouse
    • Tsuji, S. & Meier, H. Evidence for allelism of leaner and tottering in the mouse. Genet. Res. 17, 83-88 (1971).
    • (1971) Genet. Res. , vol.17 , pp. 83-88
    • Tsuji, S.1    Meier, H.2
  • 57
    • 0018416478 scopus 로고
    • Inherited epilepsy: Spike-wave and focal motor seizures in the mutant mouse tottering
    • Noebels, J.L. & Sidman, R.L. Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering. Science 204, 1334-1336 (1979).
    • (1979) Science , vol.204 , pp. 1334-1336
    • Noebels, J.L.1    Sidman, R.L.2
  • 58
    • 0021848553 scopus 로고
    • A review of mouse mutants as genetic models of epilepsy
    • Seyfried, T.N. & Glaser, G.H. A review of mouse mutants as genetic models of epilepsy. Epilepsia 26, 143-150 (1985).
    • (1985) Epilepsia , vol.26 , pp. 143-150
    • Seyfried, T.N.1    Glaser, G.H.2
  • 59
    • 0030584085 scopus 로고    scopus 로고
    • Absence epilepsy in tottering mutant mice is associated with calcium channel defects
    • Fletcher, C.F. et al. Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Cell 87, 607-617 (1996).
    • (1996) Cell , vol.87 , pp. 607-617
    • Fletcher, C.F.1
  • 60
    • 0032837377 scopus 로고    scopus 로고
    • Ataxic mouse mutants and molecular mechanisms of absence epilepsy
    • Fletcher, C.F. & Frankel, W.N. Ataxic mouse mutants and molecular mechanisms of absence epilepsy. Hum. Mol. Genet. 8, 1907-1912 (1999).
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1907-1912
    • Fletcher, C.F.1    Frankel, W.N.2
  • 61
    • 84902198155 scopus 로고    scopus 로고
    • The voltage-gated calcium channel and absence epilepsy
    • (eds. Noebels, J.L., Avoli, M., Rogawski, M.A., Olsen, R.W. & Delgado-Escueta, A.V.) Bethesda
    • Noebels, J.L. The voltage-gated calcium channel and absence epilepsy. in Jasper's Basic Mechanisms of the Epilepsies (eds. Noebels, J.L., Avoli, M., Rogawski, M.A., Olsen, R.W. & Delgado-Escueta, A.V.) (Bethesda, 2012).
    • (2012) Jasper's Basic Mechanisms of the Epilepsies
    • Noebels, J.L.1
  • 62
    • 36248960553 scopus 로고    scopus 로고
    • Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice
    • Jones, D.L. & Baraban, S.C. Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice. J. Neurophysiol. 98, 2737-2746 (2007).
    • (2007) J. Neurophysiol. , vol.98 , pp. 2737-2746
    • Jones, D.L.1    Baraban, S.C.2
  • 63
    • 33847652935 scopus 로고    scopus 로고
    • Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1
    • Wang, Y. et al. Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1. Ann. Neurol. 61, 139-152 (2007).
    • (2007) Ann. Neurol. , vol.61 , pp. 139-152
    • Wang, Y.1
  • 64
    • 33748115786 scopus 로고    scopus 로고
    • Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy
    • Yu, F.H. et al. Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat. Neurosci. 9, 1142-1149 (2006).
    • (2006) Nat. Neurosci. , vol.9 , pp. 1142-1149
    • Yu, F.H.1
  • 65
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng, L.H., Xu, L., Gutmann, D.H. & Wong, M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann. Neurol. 63, 444-453 (2008).
    • (2008) Ann. Neurol. , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 66
    • 84866500624 scopus 로고    scopus 로고
    • Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission
    • Han, S. et al. Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature 489, 385-390 (2012).
    • (2012) Nature , vol.489 , pp. 385-390
    • Han, S.1
  • 67
    • 0036338740 scopus 로고    scopus 로고
    • The genetic absence epilepsy rat from Strasbourg (GAERS), a rat model of absence epilepsy: Computer modeling and differential gene expression
    • Lakaye, B., Thomas, E., Minet, A. & Grisar, T. The genetic absence epilepsy rat from Strasbourg (GAERS), a rat model of absence epilepsy: computer modeling and differential gene expression. Epilepsia 43 (suppl. 5), 123-129 (2002).
    • (2002) Epilepsia , vol.43 , pp. 123-129
    • Lakaye, B.1    Thomas, E.2    Minet, A.3    Grisar, T.4
  • 68
    • 84865080031 scopus 로고    scopus 로고
    • A rat model for LGI1-related epilepsies
    • Baulac, S. et al. A rat model for LGI1-related epilepsies. Hum. Mol. Genet. 21, 3546-3557 (2012).
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 3546-3557
    • Baulac, S.1
  • 69
    • 0017797307 scopus 로고
    • Temperature-induced seizure and frequency-dependent neuromuscular block in a ts mutant of Drosophila
    • Salkoff, L. & Kelly, L. Temperature-induced seizure and frequency-dependent neuromuscular block in a ts mutant of Drosophila. Nature 273, 156-158 (1978).
    • (1978) Nature , vol.273 , pp. 156-158
    • Salkoff, L.1    Kelly, L.2
  • 70
    • 84867244508 scopus 로고    scopus 로고
    • A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure
    • Sun, L. et al. A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure. J. Neurosci. 32, 14145-14155 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 14145-14155
    • Sun, L.1
  • 71
    • 0035956488 scopus 로고    scopus 로고
    • Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation
    • Abou-Khalil, B. et al. Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation. Neurology 57, 2265-2272 (2001).
    • (2001) Neurology , vol.57 , pp. 2265-2272
    • Abou-Khalil, B.1
  • 72
    • 58249130592 scopus 로고    scopus 로고
    • A catalog of SCN1A variants
    • Lossin, C. A catalog of SCN1A variants. Brain Dev. 31, 114-130 (2009).
    • (2009) Brain Dev. , vol.31 , pp. 114-130
    • Lossin, C.1
  • 73
    • 0023225798 scopus 로고
    • Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila
    • Papazian, D.M., Schwarz, T.L., Tempel, B.L., Jan, Y.N. & Jan, L.Y. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science 237, 749-753 (1987).
    • (1987) Science , vol.237 , pp. 749-753
    • Papazian, D.M.1    Schwarz, T.L.2    Tempel, B.L.3    Jan, Y.N.4    Jan, L.Y.5
  • 74
    • 0032055649 scopus 로고    scopus 로고
    • Deletion of the K(V)1.1 potassium channel causes epilepsy in mice
    • Smart, S.L. et al. Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron 20, 809-819 (1998).
    • (1998) Neuron , vol.20 , pp. 809-819
    • Smart, S.L.1
  • 75
    • 0032895470 scopus 로고    scopus 로고
    • A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy
    • Zuberi, S.M. et al. A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy. Brain 122 (Pt 5): 817-825 (1999).
    • (1999) Brain , vol.122 , Issue.5 , pp. 817-825
    • Zuberi, S.M.1
  • 76
    • 0032860274 scopus 로고    scopus 로고
    • Detecting genes in new and old mouse models for epilepsy: A prospectus through the magnifying glass
    • Frankel, W.N. Detecting genes in new and old mouse models for epilepsy: a prospectus through the magnifying glass. Epilepsy Res. 36, 97-110 (1999).
    • (1999) Epilepsy Res. , vol.36 , pp. 97-110
    • Frankel, W.N.1
  • 77
    • 84900862090 scopus 로고    scopus 로고
    • The hidden genetics of epilepsy - A clinically important new paradigm
    • Thomas, R.H. & Berkovic, S.F. The hidden genetics of epilepsy - a clinically important new paradigm. Nat. Rev. Neurol. 10, 283-292 (2014).
    • (2014) Nat. Rev. Neurol. , vol.10 , pp. 283-292
    • Thomas, R.H.1    Berkovic, S.F.2
  • 78
    • 4644264353 scopus 로고    scopus 로고
    • Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans
    • Williams, S.N., Locke, C.J., Braden, A.L., Caldwell, K.A. & Caldwell, G.A. Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. Hum. Mol. Genet. 13, 2043-2059 (2004).
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2043-2059
    • Williams, S.N.1    Locke, C.J.2    Braden, A.L.3    Caldwell, K.A.4    Caldwell, G.A.5
  • 79
    • 79952308317 scopus 로고    scopus 로고
    • Action potentials drive body wall muscle contractions in Caenorhabditis elegans
    • Gao, S. & Zhen, M. Action potentials drive body wall muscle contractions in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 108, 2557-2562 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 2557-2562
    • Gao, S.1    Zhen, M.2
  • 80
    • 0001670257 scopus 로고
    • On the early development-bipolar differentiation and cleavage-of the zebra fish, Brachydanio rerio
    • Roosen-Runge, E.C. On the early development-bipolar differentiation and cleavage-of the zebra fish, Brachydanio rerio. Biol. Bull. 75, 119-133 (1938).
    • (1938) Biol. Bull. , vol.75 , pp. 119-133
    • Roosen-Runge, E.C.1
  • 81
    • 84876798186 scopus 로고    scopus 로고
    • The zebrafish reference genome sequence and its relationship to the human genome
    • Howe, K. et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature 496, 498-503 (2013).
    • (2013) Nature , vol.496 , pp. 498-503
    • Howe, K.1
  • 82
    • 13844314605 scopus 로고    scopus 로고
    • Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    • Baraban, S.C., Taylor, M.R., Castro, P.A. & Baier, H. Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience 131, 759-768 (2005).
    • (2005) Neuroscience , vol.131 , pp. 759-768
    • Baraban, S.C.1    Taylor, M.R.2    Castro, P.A.3    Baier, H.4
  • 83
    • 84863850976 scopus 로고    scopus 로고
    • A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDAtype glutamate receptors
    • Hunt, R.F., Hortopan, G.A., Gillespie, A. & Baraban, S.C. A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDAtype glutamate receptors. Exp. Neurol. 237, 199-206 (2012).
    • (2012) Exp. Neurol. , vol.237 , pp. 199-206
    • Hunt, R.F.1    Hortopan, G.A.2    Gillespie, A.3    Baraban, S.C.4
  • 85
    • 12644302205 scopus 로고    scopus 로고
    • Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva
    • Granato, M. et al. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development 123, 399-413 (1996).
    • (1996) Development , vol.123 , pp. 399-413
    • Granato, M.1
  • 86
    • 55449115663 scopus 로고    scopus 로고
    • Forward genetic analysis of visual behavior in zebrafish
    • Muto, A. et al. Forward genetic analysis of visual behavior in zebrafish. PLoS Genet. 1, e66 (2005).
    • (2005) PLoS Genet. , vol.1 , pp. e66
    • Muto, A.1
  • 87
    • 77958050908 scopus 로고    scopus 로고
    • Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish
    • Hortopan, G.A., Dinday, M.T. & Baraban, S.C. Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish. J. Neurosci. 30, 13718-13728 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 13718-13728
    • Hortopan, G.A.1    Dinday, M.T.2    Baraban, S.C.3
  • 88
    • 84884165152 scopus 로고    scopus 로고
    • Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
    • Baraban, S.C., Dinday, M.T. & Hortopan, G.A. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat. Commun. 4, 2410 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2410
    • Baraban, S.C.1    Dinday, M.T.2    Hortopan, G.A.3
  • 89
    • 84859227360 scopus 로고    scopus 로고
    • Impaired neural development in a zebrafish model for Lowe syndrome
    • Ramirez, I.B. et al. Impaired neural development in a zebrafish model for Lowe syndrome. Hum. Mol. Genet. 21, 1744-1759 (2012).
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 1744-1759
    • Ramirez, I.B.1
  • 90
    • 84875761884 scopus 로고    scopus 로고
    • Forebrain electrophysiological recording in larval zebrafish
    • published online, 24 January
    • Baraban, S.C. Forebrain electrophysiological recording in larval zebrafish. J. Vis. Exp. published online, doi:10.3791/50104 (24 January 2013).
    • (2013) J. Vis. Exp.
    • Baraban, S.C.1
  • 91
    • 34249806712 scopus 로고    scopus 로고
    • A large-scale mutagenesis screen to identify seizure-resistant zebrafish
    • Baraban, S.C. et al. A large-scale mutagenesis screen to identify seizure-resistant zebrafish. Epilepsia 48, 1151-1157 (2007).
    • (2007) Epilepsia , vol.48 , pp. 1151-1157
    • Baraban, S.C.1
  • 92
  • 93
    • 79960352003 scopus 로고    scopus 로고
    • Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish
    • Hortopan, G.A. & Baraban, S.C. Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish. Dev. Dyn. 240, 1964-1976 (2011).
    • (2011) Dev. Dyn. , vol.240 , pp. 1964-1976
    • Hortopan, G.A.1    Baraban, S.C.2
  • 94
    • 84876807823 scopus 로고    scopus 로고
    • A systematic genome-wide analysis of zebrafish proteincoding gene function
    • Kettleborough, R.N. et al. A systematic genome-wide analysis of zebrafish proteincoding gene function. Nature 496, 494-497 (2013).
    • (2013) Nature , vol.496 , pp. 494-497
    • Kettleborough, R.N.1
  • 96
    • 77958491657 scopus 로고    scopus 로고
    • Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype
    • Teng, Y. et al. Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype. Hum. Mol. Genet. 19, 4409-4420 (2010).
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 4409-4420
    • Teng, Y.1
  • 97
    • 84890151248 scopus 로고    scopus 로고
    • De novo loss-of-function mutations in CHD2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with Dravet syndrome
    • Suls, A. et al. De novo loss-of-function mutations in CHD2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with Dravet syndrome. Am. J. Hum. Genet. 93, 967-975 (2013).
    • (2013) Am. J. Hum. Genet. , vol.93 , pp. 967-975
    • Suls, A.1
  • 99
    • 84874617789 scopus 로고    scopus 로고
    • Efficient genome editing in zebrafish using a CRISPR-Cas system
    • Hwang, W.Y. et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol. 31, 227-229 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 227-229
    • Hwang, W.Y.1
  • 100
    • 84875824585 scopus 로고    scopus 로고
    • Integrating anatomy and function for zebrafish circuit analysis
    • Arrenberg, A.B. & Driever, W. Integrating anatomy and function for zebrafish circuit analysis. Front. Neural. Circuits 7, 74 (2013).
    • (2013) Front. Neural.Circuits , vol.7 , pp. 74
    • Arrenberg, A.B.1    Driever, W.2
  • 101
    • 84883254611 scopus 로고    scopus 로고
    • Two-photon imaging of neural population activity in zebrafish
    • Renninger, S.L. & Orger, M.B. Two-photon imaging of neural population activity in zebrafish. Methods 62, 255-267 (2013).
    • (2013) Methods , vol.62 , pp. 255-267
    • Renninger, S.L.1    Orger, M.B.2
  • 102
    • 85046066318 scopus 로고
    • Genetic differences in fatal audiogenic seizures between two inbred strains of house mice
    • Hall, C.S. Genetic differences in fatal audiogenic seizures between two inbred strains of house mice. J. Hered. 38, 2-6 (1947).
    • (1947) J. Hered. , vol.38 , pp. 2-6
    • Hall, C.S.1
  • 103
    • 0017356645 scopus 로고
    • Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms
    • Trimble, M., Anlezark, G. & Meldrum, B. Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms. Psychopharmacology (Berl.) 51, 159-164 (1977).
    • (1977) Psychopharmacology (Berl.) , vol.51 , pp. 159-164
    • Trimble, M.1    Anlezark, G.2    Meldrum, B.3


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