A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure

Journal of Neuroscience

Volumn 32, Issue 41, 2012, Pages 14146-14155

  Sun, Lei ^a   Gilligan, Jeff ^b   Staber, Cynthia ^b   Schutte, Ryan J ^a   Nguyen, Vivian ^a   O'Dowd, Diane K ^a   Reenan, Robert ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; PICROTOXIN; SODIUM CHANNEL NAV1.1; DROSOPHILA PROTEIN; SCN1A PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DROSOPHILA; ELECTROPHYSIOLOGY; EPILEPSY; FEBRILE CONVULSION; FEMALE; GENE MUTATION; HOMOLOGOUS RECOMBINATION; IMMUNOHISTOCHEMISTRY; INHIBITORY POSTSYNAPTIC POTENTIAL; INTERNEURON; MALE; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SODIUM CURRENT; SPIKE WAVE; TEMPERATURE STRESS; AMINO ACID SEQUENCE; ANIMAL; DISEASE MODEL; DROSOPHILA MELANOGASTER; GENE TARGETING; GENERALIZED EPILEPSY; GENETICS; HEAT; HUMAN; METHODOLOGY; MOLECULAR GENETICS; MUTATION; PATHOPHYSIOLOGY; SEIZURE; TRANSGENIC ANIMAL;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EPILEPSY; EPILEPSY, GENERALIZED; FEMALE; GENE KNOCK-IN TECHNIQUES; HOT TEMPERATURE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; SEIZURES; SEIZURES, FEBRILE;

EID: 84867244508     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2932-12.2012     Document Type: Article

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