Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

Nature Communications

Volumn 4, Issue , 2013, Pages

  Baraban, Scott C ^a,b   Dinday, Matthew T ^a   Hortopan, Gabriela A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ACETAZOLAMIDE; CARBAMAZEPINE; CLEMIZOLE; DIAZEPAM; ETHOSUXIMIDE; MESSENGER RNA; PHENYTOIN; POTASSIUM BROMIDE; SODIUM CHANNEL NAV1.1; STIRIPENTOL; VALPROIC ACID; VIGABATRIN;

COMPENSATION; CYPRINID; DRUG RESISTANCE; GENE EXPRESSION; MUTATION; PHENOTYPE; SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBELLUM; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; CONVULSION; DRUG IDENTIFICATION; DRUG SCREENING; ELECTROGRAPHY; EMBRYO; EPILEPTIC DISCHARGE; FOOD AND DRUG ADMINISTRATION; GAP JUNCTION; GENE EXPRESSION; GENE MUTATION; HIGH THROUGHPUT SCREENING; HYPERACTIVITY; IN SITU HYBRIDIZATION; KETOGENIC DIET; LARVAL DEVELOPMENT; LOCOMOTION; MICROARRAY ANALYSIS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SUPERIOR COLLICULUS; SYNAPTOGENESIS; TELENCEPHALON; WILD TYPE; ZEBRA FISH;

UNITED STATES;

ANIMALS; ANTICONVULSANTS; BENZIMIDAZOLES; BROMIDES; DIAZEPAM; DIOXOLANES; DRUG EVALUATION, PRECLINICAL; EPILEPSIES, MYOCLONIC; GENE EXPRESSION PROFILING; MUTATION; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; POTASSIUM COMPOUNDS; SEIZURES; VALPROIC ACID; VOLTAGE-GATED SODIUM CHANNEL BETA-1 SUBUNIT; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84884165152     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3410     Document Type: Article

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