Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

Immunogenetics

Volumn 67, Issue 1, 2015, Pages 61-66

  Xochelli, Aliki ^a   Agathangelidis, Andreas ^b   Kavakiotis, Ioannis ^c   Minga, Evangelia ^a   Sutton, Lesley Ann ^d   Baliakas, Panagiotis ^d   Chouvarda, Ioanna ^a,c   Giudicelli, Véronique ^e   Vlahavas, Ioannis ^c   Maglaveras, Nikos ^a,c   Bonello, Lisa ^f   Trentin, Livio ^g   Tedeschi, Alessandra ^h   Panagiotidis, Panagiotis ⁱ   Geisler, Christian ^j   Langerak, Anton W ^k   Pospisilova, Sarka ^l   Jelinek, Diane F ^m   Oscier, David ⁿ   Chiorazzi, Nicholas ^o   Darzentas, Nikos ^l   Davi, Fred ^p   Ghia, Paolo ^b,q   Rosenquist, Richard ^d   Hadzidimitriou, Anastasia ^a,d   Belessi, Chrysoula ^r   Lefranc, Marie Paule ^e   Stamatopoulos, Kostas ^a,d,s   more..

^a INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^d UPPSALA UNIVERSITY   (Sweden)

^e UNIVERSITÉ PARIS EST   (France)

^f MOLINETTE HOSPITAL   (Italy)

^g UNIVERSITY OF PADOVA   (Italy)

^h OSPEDALE NIGUARDA CA GRANDA   (Italy)

ⁱ UNIVERSITY OF ATHENS   (Greece)

^j International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^k ERASMUS MEDICAL CENTER   (Netherlands)

^l MASARYK UNIVERSITY   (Czech Republic)

^m MAYO CLINIC   (United States)

ⁿ ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

^o FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^p SORBONNE UNIVERSITÉ   (France)

^q VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^r GENERAL HOSPITAL OF NIKEA   (Greece)

^s G PAPANICOLAOU HOSPITAL   (Greece)

more..

Author keywords

CLL; New IGHV gene alleles; New IGHV genes; Prognostication; SHM

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; T LYMPHOCYTE RECEPTOR; COMPLEMENTARITY DETERMINING REGION;

ALLELE; ARTICLE; CANCER RESEARCH; CHRONIC LYMPHATIC LEUKEMIA; GENE; GENE REARRANGEMENT; IMMUNOGENETICS; IMMUNOGLOBULIN HEAVY VARIABLE GENE; NEXT GENERATION SEQUENCING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGNOSTIC ASSESSMENT; SOMATIC HYPERMUTATION; AMINO ACID SEQUENCE; COMPLEMENTARITY DETERMINING REGION; GENETICS; HUMAN; IMMUNOLOGY; MUTATION; PATHOLOGY; PROGNOSIS; SEQUENCE ALIGNMENT;

ALLELES; AMINO ACID SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MUTATION; PROGNOSIS; SEQUENCE ALIGNMENT;

EID: 84923646196     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-014-0812-3     Document Type: Article

References (17)

1. Alamyar E, Duroux P, Lefranc MP, Giudicelli V (2012a) IMGT((R)) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS. Methods Mol Biol 882:569–604
2. Alamyar E, Giudicelli V, Shuo L, Duroux P, Lefranc M (2012b) IMGT(R) web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing. Immunome Res 8:26
3. Barbas SM, Ditzel HJ, Salonen EM, Yang WP, Silverman GJ, Burton DR (1995) Human autoantibody recognition of DNA. Proc Natl Acad Sci U S A 92:2529–2533
4. Brochet X, Lefranc MP, Giudicelli V (2008) IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res 36:W503–W508
5. Chiorazzi N, Ferrarini M (2011) Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood 117:1781–1791
6. Chiorazzi N, Rai KR, Ferrarini M (2005) Chronic lymphocytic leukemia. N Engl J Med 352:804–815
7. Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, Buchbinder A, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Vinciguerra VP, Rai KR, Ferrarini M, Chiorazzi N (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94:1840–1847
8. Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stilgenbauer S, Stevenson F, Davi F, Rosenquist R (2007) ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia. Leukemia 21:1–3
9. Giudicelli V, Chaume D, Lefranc MP (2005) IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res 33:D256–D261
10. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK (1999) Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94:1848–1854
11. Langerak AW, Davi F, Ghia P, Hadzidimitriou A, Murray F, Potter KN, Rosenquist R, Stamatopoulos K, Belessi C (2011) Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases. Leukemia 25:979–984
12. Lefranc MP (2014) Immunoglobulin and T cell receptor genes: IMGT((R)) and the birth and rise of immunoinformatics. Front Immunol 5:22
13. Lefranc MP, Giudicelli V, Ginestoux C, Jabado-Michaloud J, Folch G, Bellahcene F, Wu Y, Gemrot E, Brochet X, Lane J, Regnier L, Ehrenmann F, Lefranc G, Duroux P (2009) IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res 37:D1006–D1012
14. Li S, Lefranc MP, Miles JJ, Alamyar E, Giudicelli V, Duroux P, Freeman JD, Corbin VD, Scheerlinck JP, Frohman MA, Cameron PU, Plebanski M, Loveland B, Burrows SR, Papenfuss AT, Gowans EJ (2013) IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling. Nat Commun 4:2333
15. Murray F, Darzentas N, Hadzidimitriou A, Tobin G, Boudjogra M, Scielzo C, Laoutaris N, Karlsson K, Baran-Marzsak F, Tsaftaris A, Moreno C, Anagnostopoulos A, Caligaris-Cappio F, Vaur D, Ouzounis C, Belessi C, Ghia P, Davi F, Rosenquist R, Stamatopoulos K (2008) Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 111:1524–1533
16. Sutton LA, Agathangelidis A, Belessi C, Darzentas N, Davi F, Ghia P, Rosenquist R, Stamatopoulos K (2013) Antigen selection in B-cell lymphomas—tracing the evidence. Semin Cancer Biol 23:399–409
17. Watson CT, Steinberg KM, Huddleston J, Warren RL, Malig M, Schein J, Willsey AJ, Joy JB, Scott JK, Graves TA, Wilson RK, Holt RA, Eichler EE, Breden F (2013) Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation. Am J Hum Genet 92:530–546