Pharmacodynamics, pharmacokinetics, safety, and tolerability of encenicline, a selective α7 nicotinic receptor partial agonist, in single ascending-dose and bioavailability studies

Clinical Therapeutics

Volumn 37, Issue 2, 2015, Pages 311-324

  Barbier, Ann J ^a   Hilhorst, Martijn ^b   Vliet, André Van ^b   Snyder, Peter ^c   Palfreyman, Michael G ^a   Gawryl, Maria ^a   Dgetluck, Nancy ^a   Massaro, Monica ^a   Tiessen, Renger ^b   Timmerman, Wia ^b   Hilt, Dana C ^a  

^a FORUM Pharmaceuticals   (United States)

^b PRA Health Sciences   (Netherlands)

^c BROWN UNIVERSITY   (United States)

Author keywords

bioavailability; encenicline cognition; pharmacodynamics; pharmacokinetic profile; 7 nicotinic acetylcholine receptor agonist

Indexed keywords

ENCENICLINE; NICOTINIC RECEPTOR; PLACEBO; 7-CHLORO-N-QUINUCLIDIN-3-YL-BENZO(B)THIOPHENE-2-CARBOXAMIDE; MICROCAPSULE; NICOTINIC AGENT; QUINUCLIDINE DERIVATIVE; THIOPHENE DERIVATIVE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIGIT SYMBOL SUBSTITUTION TEST; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG DOSE ESCALATION; DRUG SAFETY; DRUG TOLERABILITY; EYE IRRITATION; FEMALE; FOOD; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NAUSEA; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; RHINITIS; SEX DIFFERENCE; SINGLE DRUG DOSE; SORE THROAT; SYSTEMATIC REVIEW; BIOAVAILABILITY; COGNITION; CROSSOVER PROCEDURE; DIET RESTRICTION; DRUG EFFECTS; FOOD DRUG INTERACTION; MICROCAPSULE; ORAL DRUG ADMINISTRATION; THERAPEUTIC EQUIVALENCE;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; CAPSULES; COGNITION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FASTING; FEMALE; FOOD-DRUG INTERACTIONS; HEALTHY VOLUNTEERS; HUMANS; MALE; NICOTINIC AGONISTS; QUINUCLIDINES; RECEPTORS, NICOTINIC; SEX FACTORS; THERAPEUTIC EQUIVALENCY; THIOPHENES;

EID: 84923652026     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2014.09.013     Document Type: Article

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